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ENGLISH ABSTRACT
早发型帕金森病的诊断与治疗中国专家共识
中华医学会神经病学分会帕金森病及运动障碍学组
中国医师协会神经内科医师分会帕金森病及运动障碍学组
作者及单位信息
·
DOI： 10.3760/cma.j.cn115354-20201119-00903
Chinese expert consensus on diagnoses and treatments of early-onset Parkinson's disease
Parkinson's Disease and Movement Disorders Group of Neurology Branch of Chinese Medical Association
Parkinson's Disease and Movement Disorders Group of Neurologist Branch of Chinese Physician Association
Tang Beisha
Chen Haibo
Chen Shengdi
Authors Info & Affiliations
Parkinson's Disease and Movement Disorders Group of Neurology Branch of Chinese Medical Association
Parkinson's Disease and Movement Disorders Group of Neurologist Branch of Chinese Physician Association
Tang Beisha
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
Chen Haibo
Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China
Chen Shengdi
Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025
·
DOI： 10.3760/cma.j.cn115354-20201119-00903
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摘要

帕金森病（Parkinson's disease，PD）是一种常见的神经系统退行性疾病，随着年龄的增长，其患病率逐年增高 [ 1 ] 。尽管PD目前多见于老年人群，但近期有研究发现，有些患者的发病年龄早于50岁，称之为早发型PD(early-onset Parkinson's disease，EOPD)，占PD的5%~10% [ 2 , 3 , 4 ] 。根据发病年龄，EOPD可进一步分为青少年型帕金森综合征(juvenile parkinsonism，JP）和青年型帕金森病（young onset Parkinson's disease，YOPD)：JP是指发病年龄<21岁的EOPD，而YOPD是指发病年龄≥21岁的EOPD。与原发性PD(idiopathic Parkinson's disease，iPD）或晚发型PD(late-onset Parkinson's disease，LOPD）相比，EOPD的发病年龄早，病程长，临床表现异质性大，症状相对不典型，易被忽视和误诊；虽对小剂量左旋多巴制剂的反应好，但更容易出现运动并发症。因此，EOPD更需要个体化治疗与管理 [ 2 , 3 , 4 ] 。为了提高临床对EOPD的认识与诊疗水平，中华医学会神经病学分会及中国医师协会神经内科医师分会帕金森病及运动障碍学组的专家们进行多方讨论，形成此专家共识，具体内容如下。

早发型帕金森病;诊断;治疗;专家共识
引用本文

中华医学会神经病学分会帕金森病及运动障碍学组,中国医师协会神经内科医师分会帕金森病及运动障碍学组. 早发型帕金森病的诊断与治疗中国专家共识[J]. 中华神经医学杂志,2021,20(02)：109-116.

DOI:10.3760/cma.j.cn115354-20201119-00903

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帕金森病（Parkinson's disease，PD）是一种常见的神经系统退行性疾病，随着年龄的增长，其患病率逐年增高 [ 1 ]。尽管PD目前多见于老年人群，但近期有研究发现，有些患者的发病年龄早于50岁，称之为早发型PD(early-onset Parkinson's disease，EOPD)，占PD的5%~10% [ 2 , 3 , 4 ]。根据发病年龄，EOPD可进一步分为青少年型帕金森综合征(juvenile parkinsonism，JP）和青年型帕金森病（young onset Parkinson's disease，YOPD)：JP是指发病年龄<21岁的EOPD，而YOPD是指发病年龄≥21岁的EOPD。与原发性PD(idiopathic Parkinson's disease，iPD）或晚发型PD(late-onset Parkinson's disease，LOPD）相比，EOPD的发病年龄早，病程长，临床表现异质性大，症状相对不典型，易被忽视和误诊；虽对小剂量左旋多巴制剂的反应好，但更容易出现运动并发症。因此，EOPD更需要个体化治疗与管理 [ 2 , 3 , 4 ]。为了提高临床对EOPD的认识与诊疗水平，中华医学会神经病学分会及中国医师协会神经内科医师分会帕金森病及运动障碍学组的专家们进行多方讨论，形成此专家共识，具体内容如下。
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备注信息
A
唐北沙，中南大学湘雅医院神经内科，长沙　410008，Email： mocdef.3ab618937gnatsb；
B
陈海波，北京医院神经内科，国家老年医学中心，北京　100730，Email： tendef.3ab62oruenbhnehc；
C
陈生弟，上海交通大学医学院附属瑞金医院神经内科，上海　200025，Email： nc.defmoabc.hjrdsnehc
D
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