首页 中华糖尿病杂志 2021年13卷06期 糖尿病神经病变诊治专家共识（2021年版）
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ENGLISH ABSTRACT
糖尿病神经病变诊治专家共识（2021年版）
中华医学会糖尿病学分会神经并发症学组 
作者及单位信息
·
DOI： 10.3760/cma.j.cn115791-20210310-00143
Expert consensus on diagnosis and treatment of diabetic neuropathy (2021 edition)
Branch Group of Neurological Complications, Chinese Diabetes Society
Shi Lixin
Zhu Dalong
Authors Info & Affiliations
Branch Group of Neurological Complications, Chinese Diabetes Society
Shi Lixin
Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
Zhu Dalong
Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210008, China
·
DOI： 10.3760/cma.j.cn115791-20210310-00143
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摘要
糖尿病神经病变是糖尿病最常见的慢性并发症，随着糖尿病神经病变临床研究的进展，国际上关于糖尿病神经病变的分型、诊断及治疗都有一定的更新。因此，中华医学会糖尿病学分会神经并发症学组组织专家们撰写了《糖尿病神经病变诊治专家共识（2021年版）》。本共识介绍了糖尿病神经病变（主要是远端对称性多发性神经病变和自主神经病变）的流行病学、发病机制、分型、筛查与诊断、预防及治疗，并针对重要部分给出要点提示。本共识旨在指导和帮助临床医师对糖尿病神经病变进行规范化的综合管理，早期防治糖尿病神经病变，延缓疾病进展。
糖尿病;神经病变;专家共识
引用本文
中华医学会糖尿病学分会神经并发症学组. 糖尿病神经病变诊治专家共识（2021年版）[J]. 中华糖尿病杂志,2021,13(06)：540-557.
DOI:10.3760/cma.j.cn115791-20210310-00143PERMISSIONS
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参考文献
1
Badiu C . Williams Textbook of Endocrinology-14th Revised Edition[J]. Acta Endocrinologica (Bucharest), 2019,15:416. DOI:
10.4183/aeb.2019.416
.
2
Pop-Busui R , Boulton AJ , Feldman EL ,et al. Diabetic neuropathy: a position statement by the American Diabetes Association[J]. Diabetes Care, 2017,40(1):136-154. DOI:
10.2337/dc16-2042
.
3
Solomon T , Wu J . Diabetic neuropathy[M]// Veves A , Giurini JM , Guzman RJ ,et al. The diabetic foot: medical and surgical management. Cham:Springer International Publishing, 2018:31-46.
4
Weisman A , Bril V , Ngo M ,et al. Identification and prediction of diabetic sensorimotor polyneuropathy using individual and simple combinations of nerve conduction study parameters[J]. PLoS One, 2013,8(3):e58783. DOI:
10.1371/journal.pone.0058783
.
5
Shabeeb D , Najafi M , Hasanzadeh G ,et al. Electrophysiological measurements of diabetic peripheral neuropathy: a systematic review[J]. Diabetes Metab Syndr, 2018,12(4):591-600. DOI:
10.1016/j.dsx.2018.03.026
.
6
Callaghan BC , Gao L , Li Y ,et al. Diabetes and obesity are the main metabolic drivers of peripheral neuropathy[J]. Ann Clin Transl Neurol, 2018,5(4):397-405. DOI:
10.1002/acn3.531
.
7
Callaghan BC , Xia R , Reynolds E ,et al. Association between metabolic syndrome components and polyneuropathy in an obese population[J]. JAMA Neurol, 2016,73(12):1468-1476. DOI:
10.1001/jamaneurol.2016.3745
.
8
Zhao Z , Ji L , Zheng L ,et al. Effectiveness of clinical alternatives to nerve conduction studies for screening for diabetic distal symmetrical polyneuropathy: a multi-center study[J]. Diabetes Res Clin Pract, 2016,115:150-156. DOI:
10.1016/j.diabres.2016.01.002
.
9
Pai YW , Lin CH , Lee IT ,et al. Prevalence and biochemical risk factors of diabetic peripheral neuropathy with or without neuropathic pain in Taiwanese adults with type 2 diabetes mellitus[J]. Diabetes Metab Syndr, 2018,12(2):111-116. DOI:
10.1016/j.dsx.2017.09.013
.
10
Pan Q , Li Q , Deng W ,et al. Prevalence and diagnosis of diabetic cardiovascular autonomic neuropathy in Beijing, China: a retrospective multicenter clinical study[J]. Front Neurosci, 2019,13:1144. DOI:
10.3389/fnins.2019.01144
.
11
Feldman EL , Nave KA , Jensen TS ,et al. New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain[J]. Neuron, 2017,93(6):1296-1313. DOI:
10.1016/j.neuron.2017.02.005
.
12
Feldman EL , Callaghan BC , Pop-Busui R ,et al. Diabetic neuropathy[J]. Nat Rev Dis Primers, 2019,5(1):42. DOI:
10.1038/s41572-019-0097-9
.
13
Calcutt NA . Diabetic neuropathy and neuropathic pain: a (con)fusion of pathogenic mechanisms?[J]. Pain, 2020,161Suppl 1:S65-S86. DOI:
10.1097/j.pain.0000000000001922
.
14
Sloan G , Selvarajah D , Tesfaye S . Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy[J/OL]. Nat Rev Endocrinol, 2021May 28[2021-05-30]. DOI:
10.1038/s41574-021-00496-z
.
15
Tesfaye S , Boulton AJ , Dickenson AH . Mechanisms and management of diabetic painful distal symmetrical polyneuropathy[J]. Diabetes Care, 2013,36(9):2456-2465. DOI:
10.2337/dc12-1964
.
16
Devigili G , Cazzato D , Lauria G . Clinical diagnosis and management of small fiber neuropathy: an update on best practice[J]. Expert Rev Neurother, 2020,20(9):967-980. DOI:
10.1080/14737175.2020.1794825
.
17
Sloan G , Shillo P , Selvarajah D ,et al. A new look at painful diabetic neuropathy[J]. Diabetes Res Clin Pract, 2018,144:177-191. DOI:
10.1016/j.diabres.2018.08.020
.
18
Volmer-Thole M , Lobmann R . Neuropathy and diabetic foot syndrome[J]. Int J Mol Sci, 2016,17(6):917. DOI:
10.3390/ijms17060917
.
19
Perkins BA , Olaleye D , Zinman B ,et al. Simple screening tests for peripheral neuropathy in the diabetes clinic[J]. Diabetes Care, 2001,24(2):250-256. DOI:
10.2337/diacare.24.2.250
.
20
Tan LS . The clinical use of the 10g monofilament and its limitations: a review[J]. Diabetes Res Clin Pract, 2010,90(1):1-7. DOI:
10.1016/j.diabres.2010.06.021
.
21
蔡洁,董继宏,汪昕. 糖尿病性周围神经病常用评分量表比较与研究[J/CD]. 中华临床医师杂志(电子版), 2009,3(1):12-17. DOI:
10.3969/j.issn.1674-0785.2009.01.004
.
22
贾建平,陈生弟. 神经病学[M]. 8版. 北京:人民卫生出版社, 2018:115-116.
23
Yasuda H , Sanada M , Kitada K ,et al. Rationale and usefulness of newly devised abbreviated diagnostic criteria and staging for diabetic polyneuropathy[J]. Diabetes Res Clin Pract, 2007,77Suppl 1:S178-S183. DOI:
10.1016/j.diabres.2007.01.053
.
24
Oyer DS , Saxon D , Shah A . Quantitative assessment of diabetic peripheral neuropathy with use of the clanging tuning fork test[J]. Endocr Pract, 2007,13(1):5-10. DOI:
10.4158/EP.13.1.5
.
25
Boulton AJ , Armstrong DG , Albert SF ,et al. Comprehensive foot examination and risk assessment: a report of the task force of the foot care interest group of the American Diabetes Association, with endorsement by the American Association of Clinical Endocrinologists[J]. Diabetes Care, 2008,31(8):1679-1685. DOI:
10.2337/dc08-9021
.
26
Lauria G , Dacci P , Lombardi R ,et al. Side and time variability of intraepidermal nerve fiber density[J]. Neurology, 2015,84(23):2368-2371. DOI:
10.1212/WNL.0000000000001666
.
27
Baron R , Maier C , Attal N ,et al. Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles[J]. Pain, 2017,158(2):261-272. DOI:
10.1097/j.pain.0000000000000753
.
28
Ishibashi F , Kojima R , Taniguchi M ,et al. The expanded bead size of corneal C-nerve fibers visualized by corneal confocal microscopy is associated with slow conduction velocity of the peripheral nerves in patients with type 2 diabetes mellitus[J]. J Diabetes Res, 2016,2016:3653459. DOI:
10.1155/2016/3653459
.
29
Xiong Q , Lu B , Ye HY ,et al. Corneal confocal microscopy as a non-invasive test to assess diabetic peripheral neuropathy[J]. Diabetes Res Clin Pract, 2018,136:85-92. DOI:
10.1016/j.diabres.2017.11.026
.
30
American Diabetes Association. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2020[J]. Diabetes Care, 2020,43Suppl 1:S14-S31. DOI:
10.2337/dc20-S002
.
31
中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中华糖尿病杂志, 2018,10(1):4-67. DOI:
10.3760/cma.j.issn.1674-5809.2018.01.003
.
32
Tesfaye S , Boulton AJ , Dyck PJ ,et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments[J]. Diabetes Care, 2010,33(10):2285-2293. DOI:
10.2337/dc10-1303
.
33
Spallone V . Update on the Impact, Diagnosis and management of cardiovascular autonomic neuropathy in diabetes: what is defined, what is new, and what is unmet[J]. Diabetes Metab J, 2019,43(1):3-30. DOI:
10.4093/dmj.2018.0259
.
34
Yun JS , Park YM , Cha SA ,et al. Progression of cardiovascular autonomic neuropathy and cardiovascular disease in type 2 diabetes[J]. Cardiovasc Diabetol, 2018,17(1):109. DOI:
10.1186/s12933-018-0752-6
.
35
Spallone V , Ziegler D , Freeman R ,et al. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management[J]. Diabetes Metab Res Rev, 2011,27(7):639-653. DOI:
10.1002/dmrr.1239
.
36
Ziegler D , Keller J , Maier C ,et al. Diabetic neuropathy[J]. Exp Clin Endocrinol Diabetes, 2014,122(7):406-415. DOI:
10.1055/s-0034-1366435
.
37
Pop-Busui R . Cardiac autonomic neuropathy in diabetes: a clinical perspective[J]. Diabetes Care, 2010,33(2):434-441. DOI:
10.2337/dc09-1294
.
38
Kumar M , Chapman A , Javed S ,et al. The investigation and treatment of diabetic gastroparesis[J]. Clin Ther, 2018,40(6):850-861. DOI:
10.1016/j.clinthera.2018.04.012
.
39
Bharucha AE , Kudva YC , Prichard DO . Diabetic gastroparesis[J]. Endocr Rev, 2019,40(5):1318-1352. DOI:
10.1210/er.2018-00161
.
40
Alipour Z , Khatib F , Tabib SM ,et al. Assessment of the prevalence of diabetic gastroparesis and validation of gastric emptying scintigraphy for diagnosis[J]. Mol Imaging Radionucl Ther, 2017,26(1):17-23. DOI:
10.4274/mirt.61587
.
41
Bradshaw LA , Cheng LK , Chung E ,et al. Diabetic gastroparesis alters the biomagnetic signature of the gastric slow wave[J]. Neurogastroenterol Motil, 2016,28(6):837-848. DOI:
10.1111/nmo.12780
.
42
中华医学会糖尿病学分会,中华医学会感染病学分会,中华医学会组织修复与再生分会. 中国糖尿病足防治指南(2019版)(Ⅱ)[J]. 中华糖尿病杂志, 2019,11(3):161-189. DOI:
10.3760/cma.j.issn.1674-5809.2019.03.005
.
43
Amarenco G , Sheikh Ismaël S , Chesnel C ,et al. Diagnosis and clinical evaluation of neurogenic bladder[J]. Eur J Phys Rehabil Med, 2017,53(6):975-980. DOI:
10.23736/S1973-9087.17.04992-9
.
44
Baines G , Da Silva AS , Araklitis G ,et al. Recent advances in urodynamics in women[J]. F1000Res, 2020,9:F1000 Faculty Rev-606. DOI:
10.12688/f1000research.24640.1
.
45
Kempler P , Amarenco G , Freeman R ,et al. Management strategies for gastrointestinal, erectile, bladder, and sudomotor dysfunction in patients with diabetes[J]. Diabetes Metab Res Rev, 2011,27(7):665-677. DOI:
10.1002/dmrr.1223
.
46
Lim LL , Fu A , Lau E ,et al. Sudomotor dysfunction independently predicts incident cardiovascular-renal events and all-cause death in type 2 diabetes: the Joint Asia Diabetes Evaluation register[J]. Nephrol Dial Transplant, 2019,34(8):1320-1328. DOI:
10.1093/ndt/gfy154
.
47
Mao F , Liu S , Qiao X ,et al. Sudoscan is an effective screening method for asymptomatic diabetic neuropathy in Chinese type 2 diabetes mellitus patients[J]. J Diabetes Investig, 2017,8(3):363-368. DOI:
10.1111/jdi.12575
.
48
Tentolouris N , Achtsidis V , Marinou K ,et al. Evaluation of the self-administered indicator plaster neuropad for the diagnosis of neuropathy in diabetes[J]. Diabetes Care, 2008,31(2):236-237. DOI:
10.2337/dc07-1942
.
49
沈洁,曹瑛,陈志,等. 排汗神经功能检测在2型糖尿病患者自主神经病变评估中的作用[J]. 中华糖尿病杂志, 2011,3(1):46-49. DOI:
10.3760/cma.j.issn.1674-5809.2011.01.010
.
50
Pittasch D , Lobmann R , Behrens-Baumann W ,et al. Pupil signs of sympathetic autonomic neuropathy in patients with type 1 diabetes[J]. Diabetes Care, 2002,25(9):1545-1550. DOI:
10.2337/diacare.25.9.1545
.
51
Albers JW , Pop-Busui R . Diabetic neuropathy: mechanisms, emerging treatments, and subtypes[J]. Curr Neurol Neurosci Rep, 2014,14(8):473. DOI:
10.1007/s11910-014-0473-5
.
52
Smith BE . Focal and entrapment neuropathies[J]. Handb Clin Neurol, 2014,126:31-43. DOI:
10.1016/B978-0-444-53480-4.00003-5
.
53
Laughlin RS , Dyck PJ . Electrodiagnostic testing in lumbosacral plexopathies[J]. Phys Med Rehabil Clin N Am, 2013,24(1):93-105. DOI:
10.1016/j.pmr.2012.08.014
.
54
Massie R , Mauermann ML , Staff NP ,et al. Diabetic cervical radiculoplexus neuropathy: a distinct syndrome expanding the spectrum of diabetic radiculoplexus neuropathies[J]. Brain, 2012,135(Pt 10):3074-3088. DOI:
10.1093/brain/aws244
.
55
Dyck PJ , Windebank AJ . Diabetic and nondiabetic lumbosacral radiculoplexus neuropathies: new insights into pathophysiology and treatment[J]. Muscle Nerve, 2002,25(4):477-491. DOI:
10.1002/mus.10080
.
56
Selvarajah D , Kar D , Khunti K ,et al. Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention[J]. Lancet Diabetes Endocrinol, 2019,7(12):938-948. DOI:
10.1016/S2213-8587(19)30081-6
.
57
Tesfaye S , Chaturvedi N , Eaton SE ,et al. Vascular risk factors and diabetic neuropathy[J]. N Engl J Med, 2005,352(4):341-350. DOI:
10.1056/NEJMoa032782
.
58
Zochodne DW . The challenges of diabetic polyneuropathy: a brief update[J]. Curr Opin Neurol, 2019,32(5):666-675. DOI:
10.1097/WCO.0000000000000723
.
59
Diabetes Control and Complications Trial Research Group, Nathan DM , Genuth S ,et al. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus[J]. N Engl J Med, 1993,329(14):977-986. DOI:
10.1056/NEJM199309303291401
.
60
Callaghan BC , Cheng HT , Stables CL ,et al. Diabetic neuropathy: clinical manifestations and current treatments[J]. Lancet Neurol, 2012,11(6):521-534. DOI:
10.1016/S1474-4422(12)70065-0
.
61
Martin CL , Albers JW , Pop-Busui R ,et al. Neuropathy and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study[J]. Diabetes Care, 2014,37(1):31-38. DOI:
10.2337/dc13-2114
.
62
Ang L , Jaiswal M , Martin C ,et al. Glucose control and diabetic neuropathy: lessons from recent large clinical trials[J]. Curr Diab Rep, 2014,14(9):528. DOI:
10.1007/s11892-014-0528-7
.
63
Albers JW , Herman WH , Pop-Busui R ,et al. Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study[J]. Diabetes Care, 2010,33(5):1090-1096. DOI:
10.2337/dc09-1941
.
64
Pop-Busui R , Low PA , Waberski BH ,et al. Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC)[J]. Circulation, 2009,119(22):2886-2893. DOI:
10.1161/CIRCULATIONAHA.108.837369
.
65
Ismail-Beigi F , Craven T , Banerji MA ,et al. Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial[J]. Lancet, 2010,376(9739):419-430. DOI:
10.1016/S0140-6736(10)60576-4
.
66
Charles M , Ejskjaer N , Witte DR ,et al. Prevalence of neuropathy and peripheral arterial disease and the impact of treatment in people with screen-detected type 2 diabetes: the ADDITION-Denmark study[J]. Diabetes Care, 2011,34(10):2244-2249. DOI:
10.2337/dc11-0903
.
67
Callaghan BC , Little AA , Feldman EL ,et al. Enhanced glucose control for preventing and treating diabetic neuropathy[J]. Cochrane Database Syst Rev, 2012,6(6):CD007543. DOI:
10.1002/14651858.CD007543.pub2
.
68
Singleton JR , Marcus RL , Jackson JE ,et al. Exercise increases cutaneous nerve density in diabetic patients without neuropathy[J]. Ann Clin Transl Neurol, 2014,1(10):844-849. DOI:
10.1002/acn3.125
.
69
Smith AG , Russell J , Feldman EL ,et al. Lifestyle intervention for pre-diabetic neuropathy[J]. Diabetes Care, 2006,29(6):1294-1299. DOI:
10.2337/dc06-0224
.
70
Sawangjit R , Thongphui S , Chaichompu W ,et al. Efficacy and safety of mecobalamin on peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials[J]. J Altern Complement Med, 2020,26(12):1117-1129. DOI:
10.1089/acm.2020.0068
.
71
唐静,刘琛,闫素英. 甲钴胺对比α-硫辛酸治疗糖尿病周围神经病变疗效的Meta分析[J]. 中国药房, 2015,26(27):3800-3802. DOI:
10.6039/j.issn.1001-0408.2015.27.21
.
72
Han T , Bai J , Liu W ,et al. A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy[J]. Eur J Endocrinol, 2012,167(4):465-471. DOI:
10.1530/EJE-12-0555
.
73
谷伟军,陆菊明,关小宏,等. α-硫辛酸注射液对2型糖尿病患者周围神经病变的疗效和安全性[J]. 中华糖尿病杂志, 2012,4(7):412-415. DOI:
10.3760/cma.j.issn.1674-5809.2012.07.007
.
74
Ziegler D , Low PA , Litchy WJ ,et al. Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial[J]. Diabetes Care, 2011,34(9):2054-2060. DOI:
10.2337/dc11-0503
.
75
Çakici N , Fakkel TM , van Neck JW ,et al. Systematic review of treatments for diabetic peripheral neuropathy[J]. Diabet Med, 2016,33(11):1466-1476. DOI:
10.1111/dme.13083
.
76
潘颖颖. α-硫辛酸联合莫沙必利治疗糖尿病胃轻瘫的临床疗效[J]. 中华内分泌外科杂志, 2015,9(6):497-500. DOI:
10.3760/cma.j.issn.1674-6090.2015.06.015
.
77
江冬莲,石贵文. α-硫辛酸联合莫沙必利对糖尿病性胃轻瘫患者的临床疗效和不良反应的观察[J]. 世界华人消化杂志, 2018,26(1):26-30.
78
Zhang L , Zhang HY , Huang FC ,et al. Study on the clinical value of alprostadil combined with α-lipoic acid in treatment of type 2 diabetes mellitus patients with erectile dysfunction[J]. Eur Rev Med Pharmacol Sci, 2016,20(18):3930-3933.
79
唐松喜,陈书申,周辉良,等. 单用他达拉非及联用硫辛酸治疗2型糖尿病性ED的比较[J]. 中国男科学杂志, 2020,34(1):31-35. DOI:
10.3969/j.issn.1008-0848.2020.01.006
.
80
李平,马建华,高佳麟,等. 依帕司他治疗糖尿病周围神经病变安全性和有效性的随机、对照、多中心临床研究[J]. 中华内分泌代谢杂志, 2015,31(9):743-747. DOI:
10.3760/cma.j.issn.1000-6699.2015.09.001
.
81
Wang X , Lin H , Xu S ,et al. Alpha lipoic acid combined with epalrestat: a therapeutic option for patients with diabetic peripheral neuropathy[J]. Drug Des Devel Ther, 2018,12:2827-2840. DOI:
10.2147/DDDT.S168878
.
82
Hu X , Li S , Yang G ,et al. Efficacy and safety of aldose reductase inhibitor for the treatment of diabetic cardiovascular autonomic neuropathy: systematic review and meta-analysis[J]. PLoS One, 2014,9(2):e87096. DOI:
10.1371/journal.pone.0087096
.
83
Okamoto H , Nomura M , Nakaya Y ,et al. Effects of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy and gastroparesis[J]. Intern Med, 2003,42(8):655-664. DOI:
10.2169/internalmedicine.42.655
.
84
Yang BB , Hong ZW , Zhang Z ,et al. Epalrestat, an aldose reductase inhibitor, restores erectile function in streptozocin-induced diabetic rats[J]. Int J Impot Res, 2019,31(2):97-104. DOI:
10.1038/s41443-018-0075-x
.
85
Nakayama M , Nakamura J , Hamada Y ,et al. Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy[J]. Diabetes Care, 2001,24(6):1093-1098. DOI:
10.2337/diacare.24.6.1093
.
86
Shin S , Kim KJ , Chang HJ ,et al. The effect of oral prostaglandin analogue on painful diabetic neuropathy: a double-blind, randomized, controlled trial[J]. Diabetes Obes Metab, 2013,15(2):185-188. DOI:
10.1111/dom.12010
.
87
Deng H , Yin J , Zhang J ,et al. Meta-analysis of methylcobalamin alone and in combination with prostaglandin E1 in the treatment of diabetic peripheral neuropathy[J]. Endocrine, 2014,46(3):445-454. DOI:
10.1007/s12020-014-0181-6
.
88
Jiang DQ , Li MX , Ma YJ ,et al. Efficacy and safety of prostaglandin E1 plus lipoic acid combination therapy versus monotherapy for patients with diabetic peripheral neuropathy[J]. J Clin Neurosci, 2016,27:8-16. DOI:
10.1016/j.jocn.2015.07.028
.
89
仇艳玲,姜秀芳,陈淑峰,等. 己酮可可碱联合甲钴胺治疗糖尿病周围神经病变的临床研究[J]. 现代中西医结合杂志, 2020,29(3):264-267. DOI:
10.3969/j.issn.1008-8849.2020.03.009
.
90
Hosseini F , Mohammadbeigi A , Aghaali M ,et al. Effect of pentoxifylline on diabetic distal polyneuropathy in type 2 diabetic patients: a randomized trial[J]. J Res Med Sci, 2019,24:89. DOI:
10.4103/jrms.JRMS_115_18
.
91
Jin YP , Su XF , Li HQ ,et al. The therapeutic effect of pancreatic kininogenase on treatment of diabetic peripheral neuropathy in patients with type 2 diabetes[J]. Exp Clin Endocrinol Diabetes, 2016,124(10):618-621. DOI:
10.1055/s-0042-107242
.
92
王滨,赵立伟. 巴曲酶治疗糖尿病性周围神经病变疗效观察[J]. 中国临床医学, 2006,13(6):898-899. DOI:
10.3969/j.issn.1008-6358.2006.06.010
.
93
Li S , Li Q , Li Y ,et al. Acetyl-L-carnitine in the treatment of peripheral neuropathic pain: a systematic review and meta-analysis of randomized controlled trials[J]. PLoS One, 2015,10(3):e0119479. DOI:
10.1371/journal.pone.0119479
.
94
赵紫楠,吕俊玲,李超,等. 乙酰左卡尼汀预防和治疗糖尿病周围神经病变的快速卫生技术评估[J]. 临床药物治疗杂志, 2019,17(6):11-13, 45. DOI:
10.3969/j.issn.1672-3384.2019.06.003
.
95
李兰生. 对比木丹颗粒与弥可保治疗糖尿病周围神经病变的临床效果[J]. 中国现代药物应用, 2015,9(16):30-31. DOI:
10.14164/j.cnki.cn11-5581/r.2015.16.015
.
96
Sadosky A , Schaefer C , Mann R ,et al. Burden of illness associated with painful diabetic peripheral neuropathy among adults seeking treatment in the US: results from a retrospective chart review and cross-sectional survey[J]. Diabetes Metab Syndr Obes, 2013,6:79-92. DOI:
10.2147/DMSO.S37415
.
97
Waldfogel JM , Nesbit SA , Dy SM ,et al. Pharmacotherapy for diabetic peripheral neuropathy pain and quality of life: a systematic review[J]. Neurology, 2017,88(20):1958-1967. DOI:
10.1212/WNL.0000000000003882
.
98
Bril V , England J , Franklin GM ,et al. Evidence-based guideline: treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation[J]. Neurology, 2011,76(20):1758-1765. DOI:
10.1212/WNL.0b013e3182166ebe
.
99
Griebeler ML , Morey-Vargas OL , Brito JP ,et al. Pharmacologic interventions for painful diabetic neuropathy: an umbrella systematic review and comparative effectiveness network meta-analysis[J]. Ann Intern Med, 2014,161(9):639-649. DOI:
10.7326/M14-0511
.
100
Ziegler D , Fonseca V . From guideline to patient: a review of recent recommendations for pharmacotherapy of painful diabetic neuropathy[J]. J Diabetes Complications, 2015,29(1):146-156. DOI:
10.1016/j.jdiacomp.2014.08.008
.
101
Finnerup NB , Attal N , Haroutounian S ,et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis[J]. Lancet Neurol, 2015,14(2):162-173. DOI:
10.1016/S1474-4422(14)70251-0
.
102
Tesfaye S , Wilhelm S , Lledo A ,et al. Duloxetine and pregabalin: high-dose monotherapy or their combination? The “COMBO-DN study”--a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain[J]. Pain, 2013,154(12):2616-2625. DOI:
10.1016/j.pain.2013.05.043
.
103
Wiffen PJ , Derry S , Bell RF ,et al. Gabapentin for chronic neuropathic pain in adults[J]. Cochrane Database Syst Rev, 2017,6(6):CD007938. DOI:
10.1002/14651858.CD007938.pub4
.
104
Wernicke JF , Pritchett YL , D′Souza DN ,et al. A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain[J]. Neurology, 2006,67(8):1411-1420. DOI:
10.1212/01.wnl.0000240225.04000.1a
.
105
Tesfaye S , Vileikyte L , Rayman G ,et al. Painful diabetic peripheral neuropathy: consensus recommendations on diagnosis, assessment and management[J]. Diabetes Metab Res Rev, 2011,27(7):629-638. DOI:
10.1002/dmrr.1225
.
106
Baron R , Mayoral V , Leijon G ,et al. 5% lidocaine medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study[J]. Curr Med Res Opin, 2009,25(7):1663-1676. DOI:
10.1185/03007990903047880
.
107
Tong Y , Guo H , Han B . Fifteen-day acupuncture treatment relieves diabetic peripheral neuropathy[J]. J Acupunct Meridian Stud, 2010,3(2):95-103. DOI:
10.1016/S2005-2901(10)60018-0
.
108
Garrow AP , Xing M , Vere J ,et al. Role of acupuncture in the management of diabetic painful neuropathy (DPN): a pilot RCT[J]. Acupunct Med, 2014,32(3):242-249. DOI:
10.1136/acupmed-2013-010495
.
109
Thakral G , Kim PJ , LaFontaine J ,et al. Electrical stimulation as an adjunctive treatment of painful and sensory diabetic neuropathy[J]. J Diabetes Sci Technol, 2013,7(5):1202-1209. DOI:
10.1177/193229681300700510
.
110
Boulton AJ . Diabetic neuropathy and foot complications[J]. Handb Clin Neurol, 2014,126:97-107. DOI:
10.1016/B978-0-444-53480-4.00008-4
.
111
Jiang Y , Wang X , Xia L ,et al. A cohort study of diabetic patients and diabetic foot ulceration patients in China[J]. Wound Repair Regen, 2015,23(2):222-230. DOI:
10.1111/wrr.12263
.
112
Zhao J , Deng W , Zhang Y ,et al. Association between serum cystatin C and diabetic foot ulceration in patients with type 2 diabetes: a cross-sectional study[J]. J Diabetes Res, 2016,2016:8029340. DOI:
10.1155/2016/8029340
.
113
Brown SJ , Handsaker JC , Bowling FL ,et al. Diabetic peripheral neuropathy compromises balance during daily activities[J]. Diabetes Care, 2015,38(6):1116-1122. DOI:
10.2337/dc14-1982
.
114
Dworkin RH , Jensen MP , Gammaitoni AR ,et al. Symptom profiles differ in patients with neuropathic versus non-neuropathic pain[J]. J Pain, 2007,8(2):118-126. DOI:
10.1016/j.jpain.2006.06.005
.
115
Vileikyte L , Peyrot M , Gonzalez JS ,et al. Predictors of depressive symptoms in persons with diabetic peripheral neuropathy: a longitudinal study[J]. Diabetologia, 2009,52(7):1265-1273. DOI:
10.1007/s00125-009-1363-2
.
116
Gibbons CH , Schmidt P , Biaggioni I ,et al. The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension[J]. J Neurol, 2017,264(8):1567-1582. DOI:
10.1007/s00415-016-8375-x
.
117
Jordan J , Shannon JR , Black BK ,et al. The pressor response to water drinking in humans: a sympathetic reflex?[J]. Circulation, 2000,101(5):504-509. DOI:
10.1161/01.cir.101.5.504
.
118
Parsaik AK , Singh B , Altayar O ,et al. Midodrine for orthostatic hypotension: a systematic review and meta-analysis of clinical trials[J]. J Gen Intern Med, 2013,28(11):1496-1503. DOI:
10.1007/s11606-013-2520-3
.
119
Elgebaly A , Abdelazeim B , Mattar O ,et al. Meta-analysis of the safety and efficacy of droxidopa for neurogenic orthostatic hypotension[J]. Clin Auton Res, 2016,26(3):171-180. DOI:
10.1007/s10286-016-0349-7
.
120
van Lieshout JJ , ten Harkel AD , Wieling W . Fludrocortisone and sleeping in the head-up position limit the postural decrease in cardiac output in autonomic failure[J]. Clin Auton Res, 2000,10(1):35-42. DOI:
10.1007/BF02291388
.
121
Singer W , Sandroni P , Opfer-Gehrking TL ,et al. Pyridostigmine treatment trial in neurogenic orthostatic hypotension[J]. Arch Neurol, 2006,63(4):513-518. DOI:
10.1001/archneur.63.4.noc50340
.
122
Fanciulli A , Göbel G , Ndayisaba JP ,et al. Supine hypertension in Parkinson′s disease and multiple system atrophy[J]. Clin Auton Res, 2016,26(2):97-105. DOI:
10.1007/s10286-015-0336-4
.
123
Jordan J , Fanciulli A , Tank J ,et al. Management of supine hypertension in patients with neurogenic orthostatic hypotension: scientific statement of the American Autonomic Society, European Federation of Autonomic Societies, and the European Society of Hypertension[J]. J Hypertens, 2019,37(8):1541-1546. DOI:
10.1097/HJH.0000000000002078
.
124
Okamoto LE , Gamboa A , Shibao C ,et al. Nocturnal blood pressure dipping in the hypertension of autonomic failure[J]. Hypertension, 2009,53(2):363-369. DOI:
10.1161/HYPERTENSIONAHA.108.124552
.
125
Camilleri M , Parkman HP , Shafi MA ,et al. Clinical guideline: management of gastroparesis[J]. Am J Gastroenterol, 2013,108(1):18-37, quiz 38. DOI:
10.1038/ajg.2012.373
.
126
Shaw JE , Abbott CA , Tindle K ,et al. A randomised controlled trial of topical glycopyrrolate, the first specific treatment for diabetic gustatory sweating[J]. Diabetologia, 1997,40(3):299-301. DOI:
10.1007/s001250050677
.
127
Abd El Dayem SM , Battah AA , Soliman RA . Natural progression of cardiac autonomic neuropathy in patients with type 1 diabetes: a four-year follow-up study[J]. Anadolu Kardiyol Derg, 2011,11(3):224-231. DOI:
10.5152/akd.2011.061
.
128
Gaede P , Lund-Andersen H , Parving HH ,et al. Effect of a multifactorial intervention on mortality in type 2 diabetes[J]. N Engl J Med, 2008,358(6):580-591. DOI:
10.1056/NEJMoa0706245
.
129
Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC , Miller ME ,et al. Effects of intensive glucose lowering in type 2 diabetes[J]. N Engl J Med, 2008,358(24):2545-2559. DOI:
10.1056/NEJMoa0802743
.
130
Duckworth W , Abraira C , Moritz T ,et al. Glucose control and vascular complications in veterans with type 2 diabetes[J]. N Engl J Med, 2009,360(2):129-139. DOI:
10.1056/NEJMoa0808431
.
131
ADVANCE Collaborative Group , Patel A , MacMahon S ,et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes[J]. N Engl J Med, 2008,358(24):2560-2572. DOI:
10.1056/NEJMoa0802987
.
132
Balducci S , Iacobellis G , Parisi L ,et al. Exercise training can modify the natural history of diabetic peripheral neuropathy[J]. J Diabetes Complications, 2006,20(4):216-223. DOI:
10.1016/j.jdiacomp.2005.07.005
.
133
Ziegler D , Nowak H , Kempler P ,et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis[J]. Diabet Med, 2004,21(2):114-121. DOI:
10.1111/j.1464-5491.2004.01109.x
.
134
Körei AE , Istenes I , Papanas N ,et al. Small-fiber neuropathy: a diabetic microvascular complication of special clinical, diagnostic, and prognostic importance[J]. Angiology, 2016,67(1):49-57. DOI:
10.1177/0003319715583595
.
备注信息
A
时立新，贵州医科大学附属医院内分泌代谢病科，贵阳 550004，Email：
nc.defmoabc.liamdem2691xls
B
朱大龙，南京大学医学院附属鼓楼医院内分泌科 210008，Email：
nc.defudabe.ujngnoladuhz
C
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