综述
ENGLISH ABSTRACT
玻璃体腔药物注射治疗非动脉炎性前部缺血性视神经病变研究进展
何璐
陈长征 [综述]
作者及单位信息
·
DOI: 10.3760/cma.j.cn115989-20201104-00739
Research progress of intravitreal injections for nonarteritic anterior ischemic optic neuropathy
He Lu
Chen Changzheng
Authors Info & Affiliations
He Lu
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Chen Changzheng
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China
·
DOI: 10.3760/cma.j.cn115989-20201104-00739
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摘要

非动脉炎性前部缺血性视神经病变(NAION)是常见的中老年急性视神经病变,以视盘水肿伴视野缺损为主要特征。目前NAION尚无标准治疗方案,治疗重点在于控制全身疾病及其他危险因素、减轻视盘水肿、营养神经、改善微循环等。近年来,玻璃体腔药物注射作为新的治疗手段应用于NAION治疗,其能使药物快速到达眼内靶组织,并维持较高浓度,增加疗效的同时不引起严重的全身并发症。本文主要对玻璃体腔注射抗血管内皮细胞生长因子、曲安奈德、促红细胞生成素等治疗NAION的研究进展进行综述。

非动脉炎性前部缺血性视神经病变;玻璃体腔注射;糖皮质激素;抗血管内皮细胞生长因子
ABSTRACT

Nonarteritic anterior ischemic optic neuropathy (NAION) is a common type of acute optic neuropathy in elderly, characterized by optic disc edema and visual field defect.At present, there is no generally accepted treatment, and the treatment of NAION is to control systemic disease and other risk factors, reduce optic disc edema, nurture nerve and improve microcirculation.In recent years, intravitreal drug injection has been used as a new therapy of NAION.It can make drug reach the target issue in the eye rapidly and maintain a relatively high concentration, which can enhance the efficacy without causing severe systemic complication.In this article, the effect of intravitreal injection of anti-vascular endothelial growth factor, triamcinolone acetonide, and erythropoietin in NAION was reviewed.

Nonarteritic anterior ischemic optic neuropathy;Intravitreal injection;Glucocorticoid;Anti-vascular endothelial growth factor
Chen Changzheng, Email: mocdef.3ab61hzhcnehcuhw
引用本文

何璐,陈长征. 玻璃体腔药物注射治疗非动脉炎性前部缺血性视神经病变研究进展[J]. 中华实验眼科杂志,2021,39(07):641-644.

DOI:10.3760/cma.j.cn115989-20201104-00739

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非动脉炎性前部缺血性视神经病变(nonarteritic anterior ischemic optic neuropathy,NAION)是缺血性视神经病变的常见类型,在50岁以上人群中年发病率可达0.23/万~1.02/万 [ 1 ]。临床上NAION以突发单眼无痛性视力下降伴视野缺损、视盘水肿为主要特征,其发病机制尚不明确,但目前多被接受的假设之一是睫状后动脉供血不足继发视盘急性缺血。目前,NAION的治疗重点在于控制全身疾病及其他危险因素、减轻视盘水肿、营养神经、改善微循环等,但尚无标准治疗方案。玻璃体腔药物注射能使药物快速到达眼内靶组织,并维持较高浓度,增加疗效而不引起严重的全身并发症,被广泛应用于视网膜脉络膜疾病的治疗。玻璃体腔药物注射在NAION治疗领域也取得一定的新进展,本文就玻璃体腔注射糖皮质激素、抗血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)、促红细胞生成素(erythropoietin,EPO)等药物治疗NAION进行综述。
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陈长征,Email: mocdef.3ab61hzhcnehcuhw
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中央高校基本科研业务费专项资金资助项目 (2042021kf0123)
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