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中性粒细胞、巨噬细胞和树突状细胞吞噬体成熟及其功能研究进展
张婷婷
李轶杰
李金耀
作者及单位信息
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DOI： 10.3760/cma.j.cn112309-20200828-00416
Progress of phagosome maturation and function in neutrophil, macrophage and dendritic cell
Zhang Tingting
Li Yijie
Li Jinyao
Authors Info & Affiliations
Zhang Tingting
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
Li Yijie
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
Li Jinyao
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
·
DOI： 10.3760/cma.j.cn112309-20200828-00416
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摘要

吞噬体经过早期内体、晚期内体和溶酶体融合的变化，最终生成能降解抗原或杀死病原微生物的过程称为吞噬体成熟。吞噬体在不同免疫细胞中成熟后的功能差异，导致其对抗原摄取后的加工呈现不同的特征。通过比较中性粒细胞、巨噬细胞和树突状细胞3种免疫细胞摄取抗原后的吞噬体功能差异，发现免疫细胞抗原降解能力与抗原提呈能力相反，三者中树突状细胞的抗原提呈能力最强，巨噬细胞次之，中性粒细胞最弱。免疫细胞吞噬体成熟与抗原提呈能力的深入研究，将为疫苗研制和免疫治疗提供新的思路。

吞噬体成熟;功能差异;抗原提呈
ABSTRACT

Phagosomes undergo the fusion of early endosomes, late endosomes and lysosomes, and then degrade antigens and kill pathogenic microorganisms, which is called phagosome maturation. The functional differences of phagosomes after maturation in different immune cells lead to distinct characteristics on their processing of phagocytic antigens. It has been found that the antigen degradation ability of immune cells is opposite to their antigen presentation capacity through comparing the functional differences of phagosomes from neutrophils, macrophages and dendritic cells after antigens uptake. Among them, dendritic cells have the strongest antigen presentation capacity, followed by macrophages and neutrophils. The in-depth study of immune cell phagosome maturation and antigen presentation will provide new strategies for vaccine development and immunotherapy.

Phagosome maturation;Functional differences;Antigen presentation
Li Jinyao, Email: nc.defudabe.ujxujxyjl, Tel: 0086-991-8582500
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引用本文

张婷婷,李轶杰,李金耀. 中性粒细胞、巨噬细胞和树突状细胞吞噬体成熟及其功能研究进展[J]. 中华微生物学和免疫学杂志,2021,41(07)：565-570.

DOI:10.3760/cma.j.cn112309-20200828-00416

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吞噬体也称为吞噬小体，是胞吞过程中在被吞噬物质周围形成由细胞膜向细胞内凹陷而成的囊泡结构 [ 1 ]。吞噬体是免疫过程中巨噬细胞(macrophages，MΦ)、中性粒细胞(neutrophil)和树突状细胞(dendritic cell，DC)等免疫细胞常见的亚细胞结构，其功能为杀灭和降解入侵机体的病原微生物，并对相关抗原进行加工提呈 [ 1 ]。Anne-Marie等 [ 2 ]证明吞噬体在成熟过程中需与溶酶体融合，生成兼具隔离与分解异己物质能力的吞噬溶酶体。Savina等 [ 3 ]最早研究了DC吞噬体成熟的功能差异，证明延长吞噬体成熟时间可以增强抗原的提呈能力。此后，中性粒细胞和MΦ吞噬体成熟中功能差异的研究逐渐拓宽这一领域 [ 3 , 4 ]。有效的抗原提呈对疾病的防治起到重要的作用，本文对中性粒细胞、MΦ及DC吞噬体成熟和抗原加工功能的差异进行综述。
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A
李金耀，Email： nc.defudabe.ujxujxyjl，电话：0991-8582500
B
所有作者均声明不存在利益冲突
C
国家自然科学基金 (U1803381)
新疆维吾尔自治区自然科学基金 (2017D1C048)
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