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DNA甲基化调控实体肿瘤免疫反应的研究现状
李思其
高兴林
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DOI： 10.3760/cma.j.cn112147-20201116-01098
Research status of solid tumor immunity regulated by DNA methylation
Li Siqi
Gao Xingli
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Li Siqi
Gao Xingli
·
DOI： 10.3760/cma.j.cn112147-20201116-01098
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摘要

机体的免疫功能与肿瘤的发生发展密切关联，一方面，机体可以通过免疫效应机制，包括固有免疫和特异性免疫，发挥抗肿瘤作用；另一方面，肿瘤细胞通过免疫逃逸机制逃避免疫系统的识别和清除。越来越多的证据表明表观遗传调控在实体肿瘤免疫调节中占有重要地位，其中，DNA甲基化作为目前研究最久、最深入的表观遗传机制，除了促进肿瘤的恶性转化，也影响机体免疫细胞对肿瘤的免疫应答。本文主要针对DNA甲基化对实体肿瘤免疫反应的调节作用进行阐述。

引用本文

李思其,高兴林. DNA甲基化调控实体肿瘤免疫反应的研究现状[J]. 中华结核和呼吸杂志,2021,44(10)：921-926.

DOI:10.3760/cma.j.cn112147-20201116-01098

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人体免疫功能与肿瘤的发生发展关系密切，近年来，实体肿瘤的免疫逃逸以及相关机制的研究是临床关注的热点。表观遗传调控是在不改变DNA序列的情况下，通过改变染色质结构而影响基因表达，包括DNA甲基化、组蛋白翻译后修饰和非编码RNA的调节等，是一种可遗传、可逆转的调控方式 ［ 1 ］ ，在实体肿瘤免疫调节中占有重要地位。
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高兴林，Email： mocdef.labiamtohoagnilgnix
B

李思其, 高兴林. DNA甲基化调控实体肿瘤免疫反应的研究现状[J]. 中华结核和呼吸杂志, 2021, 44(10): 921-926. DOI: 10.3760/cma.j.cn112147-20201116-01098.

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