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JAK2-STAT3信号通路在肿瘤发生发展中的作用
罗盼
曾艳
吴伟莉
作者及单位信息
·
DOI： 10.3760/cma.j.cn371439-20210428-00146
Role of JAK2-STAT3 signaling pathway in tumorigenesis and development
Luo Pan
Zeng Yan
Wu Weili
Authors Info & Affiliations
Luo Pan
Department of Oncology, School of Clinical Medicine, Guizhou Medical University, Guiyang 550000, China
Zeng Yan
Department of Oncology, School of Clinical Medicine, Guizhou Medical University, Guiyang 550000, China
Wu Weili
Department of Oncology, School of Clinical Medicine, Guizhou Medical University, Guiyang 550000, China
Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China
Depart-ment of Head and Neck Oncology, Cancer Hospital Affiliated of Guizhou Medical University, Guiyang 550000, China
·
DOI： 10.3760/cma.j.cn371439-20210428-00146
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摘要

JAK2-STAT3信号通路作为细胞内传递信号的主链，在细胞增殖、凋亡、侵袭、迁移及免疫应答等活动中起重要作用。该通路由细胞因子和干扰素触发，能迅速地将细胞外信号转导到细胞核中，在头颈部鳞状细胞癌、肺癌、食管癌、胃癌、肝癌、乳腺癌、骨髓增生性肿瘤等多种肿瘤中存在异常表达。深入了解JAK2-STAT3信号通路的致癌机制，可为临床治疗肿瘤及判断预后提供新的思考。

肿瘤;JAK2-STAT3信号通路
ABSTRACT

JAK2-STAT3 signaling pathway, as the main chain of intracellular signal transmission, plays an important role in cell proliferation, apoptosis, invasion, migration and immune response. Triggered by cytokines and interferon, this pathway can quickly transduce extracellular signals into the nucleus, and it has abnormal expression in various tumors, such as squamous cell carcinoma of the head and neck, lung cancer, esophageal cancer, gastric cancer, liver cancer, breast cancer and myeloproliferative neoplasms. Further understanding of the carcinogenic mechanism of JAK2-STAT3 signaling pathway can provide new ideas for clinical treatment of tumors and prognosis.

Neoplasms;JAK2-STAT3 signaling pathway
Wu Weili, Email: mocdef.3ab61yhmlww
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引用本文

罗盼,曾艳,吴伟莉. JAK2-STAT3信号通路在肿瘤发生发展中的作用[J]. 国际肿瘤学杂志,2021,48(12)：739-742.

DOI:10.3760/cma.j.cn371439-20210428-00146

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细胞表面的干扰素受体相互作用后可激活Janus激酶(Janus kinase，JAK)，进而激活信号转导和转录激活因子(signal transduction and activator of trans-cription，STAT)蛋白家族 [ 1 ]。JAK-STAT信号通路主要由细胞的表面受体、JAK蛋白家族以及STAT蛋白家族3部分组成。JAK家族可选择性地与膜近端结构域结合形成不同组合的受体，这些受体与配体结合后形成同源或异源二聚体启动信号转导，直接调控目的基因的转录 [ 2 ]。JAK2-STAT3是JAK-STAT信号通路家族中的主要成员，当此通路表达异常时将导致肿瘤发生，现就JAK2-STAT3信号通路异常激活在肿瘤中的作用作一综述。
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参考文献
[1]
Darnell JE Jr, Kerr IM , Stark GR . Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins[J]. Science, 1994,264(5164):1415-1421. DOI: 10.1126/science.8197455 .
返回引文位置Google Scholar
百度学术
万方数据
[2]
Levy DE , Darnell JE Jr. Stats: transcriptional control and biological impact[J]. Nat Rev Mol Cell Biol, 2002,3(9):651-662. DOI: 10.1038/nrm909 .
返回引文位置Google Scholar
百度学术
万方数据
[3]
Liu JF , Deng WW , Chen L ,et al. Inhibition of JAK2-STAT3 reduces tumor-induced angiogenesis and myeloid-derived suppressor cells in head and neck cancer[J]. Mol Carcinog, 2018,57(3):429-439. DOI: 10.1002/mc.22767 .
返回引文位置Google Scholar
百度学术
万方数据
[4]
Peng HY , Cheng YC , Hsu YM ,et al. MPT0B098, a microtubule inhibitor, suppresses JAK2-STAT3 signaling pathway through modulation of SOCS3 stability in oral squamous cell carcinoma[J]. PLoS One, 2016,11(7):e0158440. DOI: 10.1371/journal.Pone.0158440 .
返回引文位置Google Scholar
百度学术
万方数据
[5]
Yadav A , Kumar B , Datta J ,et al. IL-6 promotes head and necktumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway[J]. Mol Cancer Res, 2011,9(12):1658-1667. DOI: 10.1158/1541-7786.MCR-11-0271 .
返回引文位置Google Scholar
百度学术
万方数据
[6]
He HL , Lee YE , Liang PI ,et al. Overexpression of JAK2: a predictor o f unfavorable prognosis for nasopharyngeal carcinoma [J]. Future Oncol, 2016,12(16):1887-1896. DOI: 10.2217/fon-2016-0025 .
返回引文位置Google Scholar
百度学术
万方数据
[7]
Lin CH , Chiang MC , Chen YJ . STAT3 mediates resistance toanoikis and promotes invasiveness of nasopharyn geal cancer cells[J]. Int J Mol Med, 2017,40(5):1549-1556. DOI: 10.3892/ijmm.2017.3151 .
返回引文位置Google Scholar
百度学术
万方数据
[8]
Xu Y , Jin J , Xu J ,et al. JAK2 variations and functions in lung adenocarcinoma[J]. Tumour Biol, 2017,39(6):1010428317711140. DOI: 10.1177/1010428317711140 .
返回引文位置Google Scholar
百度学术
万方数据
[9]
Wang M , Lin T , Wang Y ,et al. CXCL12 suppresses cisplatin-induced apoptosis through activation of JAK2-STAT3 signaling in human non-small-cell lung cancer cells[J]. Onco Targets Ther, 2017,10:3215-3224. DOI: 10.2147/OTT.S133055 .
返回引文位置Google Scholar
百度学术
万方数据
[10]
Pastuszak-Lewandoska D , Domańska-Senderowska D , Kordiak J ,et al. Immunoexpression analysis of selected JAK/STAT pathway molecules in patients with non-small-cell lung cancer[J]. Pol Arch Intern Med, 2017,127(11):758-764. DOI: 10.20452/pamw.4115 .
返回引文位置Google Scholar
百度学术
万方数据
[11]
Dong Y , Xu T , Zhong S ,et al. Circ_0076305 regulates cisplatin resistance of non-small cell lung cancer via positively modulating STAT3 by sponging miR-296-5p[J]. Life Sci, 2019,239:116984. DOI: 10.1016/j.lfs.2019.116984 .
返回引文位置Google Scholar
百度学术
万方数据
[12]
Fang J , Chu L , Li C ,et al. JAK2 inhibitor blocks the inflammation and growth of esophageal squamous cell carcinoma in vitro through the JAK-STAT3 pathway[J]. Oncol Rep, 2015,33(1):494-502. DOI: 10.3892/or.2014.3609 .
返回引文位置Google Scholar
百度学术
万方数据
[13]
Liu JR , Wu WJ , Liu SX ,et al. Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2-STAT3 pathway[J]. Pathol Res Pract, 2015,211(6):426-434. DOI: 10.1016/j.prp.2015.01.007 .
返回引文位置Google Scholar
百度学术
万方数据
[14]
Liu J , Mao Y , Zhang D ,et al. Retraction notice to " MiR-143 inhibits tumor cell proliferation and invasion by targeting STAT3 in esophageal squamous cell carcinoma " [J]. Cancer Lett, 2018,422:133. DOI: 10.1016/j.canlet.2018.03.021 .
返回引文位置Google Scholar
百度学术
万方数据
[15]
Yan XL , Luo QY , Zhou SN ,et al. MicroRNA-375 reverses the expression of PD-L1 by inactivating the JAK2-STAT3 signaling pathways in gastric cancer[J]. Clin Res Hepatol Gastroenterol, 2020,30:101574. DOI: 10.1016/j.clinre.2020.10.015 .
返回引文位置Google Scholar
百度学术
万方数据
[16]
陶有茂. MicroRNA-216a通过抑制JAK2-STAT3信号通路抑制胃癌细胞侵袭转移及上皮间质转化[D]. 吉林大学， 2019.
返回引文位置Google Scholar
百度学术
万方数据
[17]
Xu XF , Gao F , Wang JJ ,et al. BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK-STAT3 signaling pathway[J]. Cancer Cell Int, 2019,19:133. DOI: 10.1186/s12935-019-0847-5 .
返回引文位置Google Scholar
百度学术
万方数据
[18]
Hin Tang JJ , <x>Hao</x> <x>Thng</x> DK , Lim JJ ,et al. JAK-STAT signaling in hepatocellular carcinoma[J]. Hepat Oncol, 2020,7(1):HEP18. DOI: 10.2217/hep-2020-0001 .
返回引文位置Google Scholar
百度学术
万方数据
[19]
Kondo R , Ishino K , Wada R ,et al. Downregulation of protein disulfide-isomerase A3 expression inhibits cell proliferation and induces apoptosis through STAT3 signaling inhepatocellular carcinoma[J]. Int J Oncol, 2019,54(4):1409-1421. DOI: 10.3892/ijo.2019.4710 .
返回引文位置Google Scholar
百度学术
万方数据
[20]
Choe MH , Min JW , Jeon HB ,et al. ERp57 modulates STAT3 activity in radior esistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer [J]. Oncotarget, 2015,6(5):2654-2666. DOI: 10.18632/oncotarget.3042 .
返回引文位置Google Scholar
百度学术
万方数据
[21]
Wan S , Zhao E , Kryczek I ,et al. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells[J]. Gastroenterology, 2014,147(6):1393-1404. DOI: 10.1053/j.gastro.2014.08.039 .
返回引文位置Google Scholar
百度学术
万方数据
[22]
Chang R , Song L , Xu Y ,et al. Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2-STAT3 axis[J]. Nat Commun, 2018,9(1):3486. DOI: 10.1038/s41467-018-05852-8 .
返回引文位置Google Scholar
百度学术
万方数据
[23]
Cheng M , Liu P , Xu LX . Iron promotes breast cancer cell migration via IL-6/JAK2/STAT3 signaling pathways in a paracrine or autocrine IL-6-rich inflammatory environment[J]. J Inorg Biochem, 2020,210:111159. DOI: 10.1016/j.jinorgbio.2020.11115 .
返回引文位置Google Scholar
百度学术
万方数据
[24]
Wang S , Liang K , Hu Q ,et al. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis[J]. J Clin Invest, 2017,127(12):4498-4515. DOI: 10.1172/JCI91553 .
返回引文位置Google Scholar
百度学术
万方数据
[25]
Roskoski R Jr. Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases[J]. Pharmacol Res, 2016,111:784-803. DOI: 10.1016/j.phrs.2016.07.038 .
返回引文位置Google Scholar
百度学术
万方数据
[26]
Bryan JC , Verstovsek S . Overcoming treatment challenges in myelofibrosis and polycythemia vera: the role of ruxolitinib[J]. Cancer Chemother Pharmacol, 2016,77(6):1125-1142. DOI: 10.1007/s00280-016-3012-z .
返回引文位置Google Scholar
百度学术
万方数据
[27]
Shastri A , Choudhary G , Teixeira M ,et al. Antisense STAT3 inhi bitor decreases viability of myelodysplastic and leukemic stem cells [J]. J Clin Invest, 2018,128(12):5479-5488. DOI: 10.1172/JCI120156 .
返回引文位置Google Scholar
百度学术
万方数据
备注信息
A
吴伟莉，Email: mocdef.3ab61yhmlww
B
所有作者均声明不存在利益冲突
C
贵州省科技计划 (黔科合基础〔2017〕1148)
贵州省教育厅创新群体重大研究项目 (黔教合KY字〔2017〕038)
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