ObjectiveTo summarize the distribution and clinical characteristics of patients with pituitary adenoma of different hormone secreting types, analyze the changes of the disease spectrum and to guide clinical diagnosis and treatment.

MethodsAll clinical data of patients with pituitary adenoma hospitalized in the First Medical Center of PLA General Hospital from Jan.1st 2005 to Dec.31rd 2020 were collected. The profile of gender ratio, age, date of admission, clinical diagnosis were retrospectively analyzed.

ResultsA total of 4 276 patients with pituitary adenoma were treated during 16 years, including 1 871 males (43.8%) and 2 405 females (56.2%) with the average age of consultation was (44.1±13.9) years. Non-functioning adenoma (60.7%), prolactinoma (16.1%) and growth hormone adenoma (13.9%) were at relatively high proportion. The visiting age of non-functioning adenoma was mostly concentrated between 41~60 years, and prolactinoma and growth hormone adenoma were mostly concentrated between 21~40 years. The number of patients with pituitary adenoma gradually increased with a peak in 2012, while the proportion of patients with growth hormone adenoma and adrenocorticotropic hormone adenoma increased and the proportion of patients with non-functional adenoma decreased slightly.

ConclusionNon-functional pituitary adenoma, prolactinoma, and growth hormone adenoma are still the most common pituitary adenoma in clinical practice. The proportion of hospitalized non-functional pituitary adenoma showes a gradual decline over time.