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狼疮抗凝物检测在静脉血栓栓塞症中的应用进展
胡长春
王晓慧
陈虹
作者及单位信息
·
DOI： 10.3760/cma.j.cn112147-20210519-00339
Progress of lupus anticoagulant detection in venous thromboembolism
Hu Changchun
Wang Xiaohui
Chen Hong
Authors Info & Affiliations
Hu Changchun
Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Wang Xiaohui
Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Chen Hong
Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
·
DOI： 10.3760/cma.j.cn112147-20210519-00339
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摘要

狼疮抗凝物是发生静脉血栓栓塞症的危险因素之一，在静脉血栓栓塞症患者中检测狼疮抗凝物，对治疗方案抉择和疗效预后判断等方面具有重要意义。目前尚无相关文献对狼疮抗凝物检测在静脉血栓栓塞症中的应用进展进行分析总结，为加深对此类患者的认识，更好地帮助临床医生对此类患者进行合理的诊治和管理，现就有关流行病学、检测注意事项及检测结果在静脉血栓栓塞症中的价值和相关治疗进行综述。

ABSTRACT

Lupus anticoagulant is one of the risk factors for venous thromboembolism, and the detection of lupus anticoagulant in patients with venous thromboembolism is important for the choice of treatment options and prognosis of treatment. There was no relevant literature to analyze and summarize the application progress of lupus anticoagulant detection in venous thromboembolism. In order to deepen the understanding of such patients, and help clinicians to conduct reasonable diagnosis, treatment and management of these patients, we reviewed the relevant epidemiology, test precautions, and the value of test results in venous thromboembolism and related treatments.

Chen Hong, Email: mocdef.6ab213002gnohepoh
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引用本文

胡长春,王晓慧,陈虹. 狼疮抗凝物检测在静脉血栓栓塞症中的应用进展[J]. 中华结核和呼吸杂志,2022,45(02)：218-221.

DOI:10.3760/cma.j.cn112147-20210519-00339

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静脉血栓栓塞症（VTE）包括深静脉血栓形成（DVT）和肺血栓栓塞症（PTE），两者易患因素相同，是VTE在不同部位、不同阶段的两种临床表现形式 ［ 1 ］ 。狼疮抗凝物（LA）是抗磷脂抗体（aPL）家族成员之一，是一组不同种类的免疫球蛋白，在体外抑制磷脂依赖的凝血反应，产生抗凝效应，而在体内却干扰凝血酶原活性，促进血栓形成 ［ 2 , 3 ］ 。LA是VTE形成的危险因素之一，在手术患者VTE风险评估表（Caprini评分表）中，LA阳性高达3分，仅此项即可使患者术后VTE发生风险达到高危（3~4分）。在临床中检测LA具有重要的价值，既能预测某些特定人群VTE的发生，又可以指导患者的治疗及预后情况，使治疗更加规范合理。
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备注信息
A
陈虹，Email： mocdef.6ab213002gnohepoh
B

胡长春, 王晓慧, 陈虹. 狼疮抗凝物检测在静脉血栓栓塞症中的应用进展[J]. 中华结核和呼吸杂志, 2022, 45(2): 218-221. DOI: 10.3760/cma.j.cn112147-20210519-00339.

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所有作者声明无利益冲突
D
重庆市卫计委卫生适宜技术 (2018jstg012，2019jstg023)
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