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生酮饮食对肥胖型哮喘的影响
孔璐丹
吴秋萍
作者及单位信息
·
DOI： 10.3760/cma.j.cn112147-20210609-00410
Effect of ketogenic diet on obesity asthma
Kong Ludan
Wu Qiuping
Authors Info & Affiliations
Kong Ludan
The Children′s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China
Wu Qiuping
The Children′s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China
·
DOI： 10.3760/cma.j.cn112147-20210609-00410
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摘要

肥胖和支气管哮喘（以下简称哮喘）之间的相关性日益受到关注，70%难治性哮喘患者超重或肥胖，肥胖已成为哮喘的重要危险因素。近年来，生酮饮食作为自然疗法之一，被证实有治疗肥胖症的作用，并且也有研究指出生酮饮食可降低哮喘气道炎症。本文总结了肥胖与哮喘的关联机制，阐述了生酮饮食影响肥胖型哮喘的潜在机制，如控制体重，减轻炎症反应，调节肠道菌群和修饰表观遗传，为肥胖型哮喘的防治提供新的思路。

ABSTRACT

Recently investigators pay more attention to the relationship between obesity and bronchial asthma (asthma).Obesity is increasingly recognized as a possible risk factor for childhood asthma, and 70% of patients with difficult-to-treat asthma are overweight or obese. In recent years, ketogenic diet, as one of the natural therapies, has been shown to have positive effects on weight loss process; and recent studies showed that ketogenic diet reduced airway inflammation in asthma. This review summarized the mechanisms of associations between obesity and asthma, and described the potential mechanisms of ketogenic diet affecting obese asthma, such as controlling body weight, reducing inflammatory response, regulating intestinal flora and modifying epigenetics, to provide new ideas for the prevention and treatment of obesity asthma.

Wu Qiuping, Email: nc.defudabe.ujz7119156
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孔璐丹,吴秋萍. 生酮饮食对肥胖型哮喘的影响[J]. 中华结核和呼吸杂志,2022,45(02)：222-226.

DOI:10.3760/cma.j.cn112147-20210609-00410

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全球哮喘防治创议（global initiative forasthma，GINA）2020年版指出哮喘是一种由多种细胞和细胞组分共同参与的慢性气道炎症性疾病，其发病机制复杂多样，临床表现也不尽相同，表现出明显的异质性 ［ 1 ］ ，并且存在不同的哮喘分型，其中肥胖型哮喘逐渐引起重视。据统计，儿童及成人肥胖的发生率逐年增高，肥胖人群哮喘患病率是非肥胖人群的两倍。肥胖型哮喘患者对常规哮喘治疗药物反应差，哮喘严重程度增加，并可能发展成难治性哮喘，病情控制不理想，生活质量低下 ［ 2 ］ 。
20世纪60年代，生酮饮食（Ketogentic diet）开始应用于治疗肥胖症，并取得一定成效 ［ 3 ］ 。近年来，生酮饮食的运用范围越来越广，在糖尿病、代谢综合征、肿瘤、多囊卵巢综合征及心血管疾病的防控方面均有作用。2020年研究表明 ［ 4 , 5 ］ ，生酮饮食在对抗哮喘的气道炎症反应方面也有积极作用，本文结合国内外相关研究进展，阐述生酮饮食对防控肥胖型哮喘的积极影响和潜在机制。
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备注信息
A
吴秋萍，Email： nc.defudabe.ujz7119156
B

孔璐丹, 吴秋萍. 生酮饮食对肥胖型哮喘的影响[J]. 中华结核和呼吸杂志, 2022, 45(2): 222-226. DOI: 10.3760/cma.j.cn112147-20210609-00410.

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