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肠道微生物普雷沃菌在肺结核研究中的价值分析及展望
周静
柴英辉
张晓萌
雷红
作者及单位信息
·
DOI： 10.3760/cma.j.cn112147-20210719-00507
Intestinal microbe Prevotella in pulmonary tuberculosis research
Zhou Jing
Chai Yinghui
Zhang Xiaomeng
Lei Hong
Authors Info & Affiliations
Zhou Jing
Graduate School, Hebei North University, Zhangjiakou 075000, China
Chai Yinghui
Laboratory Medicine, Eighth Medical Center of Chinese People′s Liberation Army General Hospital, Beijing 100091, China
Zhang Xiaomeng
Graduate School, Hebei North University, Zhangjiakou 075000, China
Lei Hong
Laboratory Medicine, Eighth Medical Center of Chinese People′s Liberation Army General Hospital, Beijing 100091, China
·
DOI： 10.3760/cma.j.cn112147-20210719-00507
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摘要

肺结核是一种严重危害人类健康的全球重大传染性疾病。研究表明，感染结核分枝杆菌后会出现肠道微生态的失衡，反之肠道菌群失调也会增加结核分枝杆菌的易感性。而普雷沃菌属是新发现的一种与炎症疾病紧密相关的肠道微生物，且在结核患者体内有明显的丰度变化。故该文就肠道微生物普雷沃菌与肺结核之间相关性研究的现状进行综述，以期为肺结核的诊断和治疗提供新的思路。

ABSTRACT

Tuberculosis is a major global infectious disease that seriously endangers human health. Studies have shown that there will be an imbalance of intestinal microecology after infection with Mycobacterium tuberculosis. And vise versa the imbalance of intestinal flora will also increase the susceptibility to Mycobacterium tuberculosis. Prevotella is a newly discovered intestinal microorganism closely related to inflammatory diseases, and its abundance changes significantly in patients with tuberculosis. Therefore, this paper reviews the correlation between intestinal microorganism Prevotella and pulmonary tuberculosis, in order to provide new ideas for the diagnosis and treatment of pulmonary tuberculosis.

Lei Hong, Email: mocdef.6ab21latipsoh-gnohiel
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周静,柴英辉,张晓萌,等. 肠道微生物普雷沃菌在肺结核研究中的价值分析及展望[J]. 中华结核和呼吸杂志,2022,45(04)：414-418.

DOI:10.3760/cma.j.cn112147-20210719-00507

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2021年10月世界卫生组织（World Health Organization，WHO）发表的《全球结核病报告》显示，据估算，目前全球结核分枝杆菌（ Mycobacterium tuberculosis，MTB）潜伏感染人群接近20亿，且结核病自2007年以来一直位居单一传染性疾病死因之首 ［ 1 ］ 。侵入人体的MTB约80%会侵犯肺脏，引起肺结核 ［ 2 , 3 ］ 。肺结核是严峻的全球性公共健康问题 ［ 4 ］ ，但其发病机制目前仍然未完全明确。
目前，随着宏基因组测序技术和生物信息学的发展，肠道微生态与人类健康和疾病的关系日益成为基础医学和临床医学研究的热点方向。近年来，已不断发现如癌症、心血管疾病、自身免疫性疾病等发病及病程进展都与肠道菌群存在联系 ［ 5 , 6 , 7 , 8 ］ 。就肺结核而言，肠道菌群的失衡会导致肺部MTB的活跃性增强 ［ 5 ］ ，降低机体免疫功能 ［ 9 , 10 , 11 ］ ，同时机体肠道中的主要菌属之一普雷沃菌属（ Prevotella），其菌群变化或许与肺结核存在重要联系。故本文就肠道微生物普雷沃菌与肺结核间关系的研究进展作一综述，以期为肺结核的相关机制研究和治疗提供新的思路。
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备注信息
A
雷红，Email： mocdef.6ab21latipsoh-gnohiel
B

周静, 柴英辉, 张晓萌, 等. 肠道微生物普雷沃菌在肺结核研究中的价值分析及展望[J]. 中华结核和呼吸杂志, 2022, 45(4): 414-418. DOI: 10.3760/cma.j.cn112147-20210719-00507.

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