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ENGLISH ABSTRACT
慢性移植物抗宿主病干眼相关生物标志物
王春苗
张琪 [综述]
作者及单位信息
·
DOI： 10.3760/cma.j.cn115989-20190121-00025
Biomarkers in ocular chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Wang Chunmiao
Zhang Qi
Authors Info & Affiliations
Wang Chunmiao
Department of Ophthalmology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing 400016, China
Zhang Qi
Department of Ophthalmology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing 400016, China
·
DOI： 10.3760/cma.j.cn115989-20190121-00025
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摘要

异基因造血干细胞移植术(allo-HSCT)是治疗血液系统恶性及非恶性疾病常见的治疗方法，而allo-HSCT后常见慢性移植物抗宿主病(cGVHD)干眼等眼部并发症，严重影响患者的生存质量，严重者可能会导致角膜穿孔甚至盲。随着allo-HSCT技术不断成熟，移植人数逐渐增多、移植后患者生存时间延长，cGVHD干眼的发生率也不断升高。目前对该病的发病机制、诊断及治疗方面的研究尚不完善，生物标志物的研究对其早期预防、诊断及治疗具有极其重要的作用。本文主要从泪腺、角结膜、睑板腺、泪液及外周血中cGVHD干眼的生物标志物研究进展做一综述。

干眼;生物标志物;造血干细胞移植;慢性移植物抗宿主病
ABSTRACT

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a common treatment for hematological malignant and non-malignant diseases.However, dry eye, ocular chronic graft-versus-host disease (cGVHD) and other common ocular complications related to cGVHD after allo-HSCT, can seriously affect the quality of life of patients, and may lead to corneal perforation or even blindness in severe cases.With the constant development of allo-HSCT, the incidence of cGVHD-related dry eye is on the rise with the increasing number of patients and the prolonged survival time after transplantation.The pathogenesis, diagnosis and treatment for the disease still remain poorly understood and studied.Biomarkers are of importance for the early prevention, diagnosis and active treatment of cGVHD-related dry eye at present.Progress of biomarkers for cGVHD-related dry eye after HSCT including lacrimal glands, cornea and conjunctiva, meibomian glands, tears and the peripheral blood were reviewed.

Dry eye syndromes;Biomarkers;Hematopoietic stem cell transplantation;Chronic graft versus host disease
Zhang Qi, Email: mocdef.3ab61mxwqzqc
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王春苗,张琪. 慢性移植物抗宿主病干眼相关生物标志物[J]. 中华实验眼科杂志,2022,40(05)：470-474.

DOI:10.3760/cma.j.cn115989-20190121-00025

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异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation，allo-HSCT)是目前治疗血液系统恶性及非恶性疾病的常见治疗方法。慢性移植物抗宿主病(chronic graft-versus-host disease，cGVHD)是allo-HSCT术后常见的晚期并发症。cGVHD干眼在移植术后发病率约为40%~60% [ 1 , 2 ]，主要症状有眼干、眼红、眼痛、异物感、溢泪等，随着病情进展，可能会导致角膜穿孔甚至盲。随着allo-HSCT技术的不断成熟及移植人数逐渐增多、术后患者生存时间延长，cGVHD干眼的发生率也不断升高，严重者可迅速进展并致盲 [ 3 ]，但目前对其发病机制、诊断及治疗方面的研究尚不完善。对于该病的生物学标志物筛选具有重要意义，本文主要从泪腺、角结膜、睑板腺、泪液及全身相关cGVHD干眼的生物标志物研究进展做一综述，以期为其早期诊断及早期治疗从而减缓疾病进展提供理论依据。
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张琪，Email： mocdef.3ab61mxwqzqc
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国家自然科学基金面上项目 (82070935)
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