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NLRP3炎症小体信号通路在糖尿病角膜病变发生和发展中的作用
万鲁芹
周庆军
谢立信 [综述]
作者及单位信息
·
DOI： 10.3760/cma.j.cn115989-20190618-00266
Role of NLRP3 inflammasome signaling pathway in the occurrence and development of diabetic keratopathy
Wan Luqin
Zhou Qingjun
Xie Lixin
Authors Info & Affiliations
Wan Luqin
Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao 266071, China
Zhou Qingjun
Eye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao 266071, China
Xie Lixin
Eye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao 266071, China
·
DOI： 10.3760/cma.j.cn115989-20190618-00266
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摘要

糖尿病角膜病变是由异常代谢产物蓄积、氧化应激、异常炎症和角膜神经病变等引起的糖尿病慢性并发症，在眼外伤或手术刺激下出现角膜上皮愈合延迟、角膜敏感性下降等表现，给临床医生带来极大的挑战。核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体的激活是引起糖尿病慢性并发症的因素之一，也是糖尿病伤口延迟愈合的重要影响因素。NLRP3炎症小体相关通路与角膜氧化应激、上皮延迟愈合及角膜神经病变的发生和发展密切相关。本文就NLRP3炎症小体信号通路与糖尿病角膜病变的研究现状及研究前景进行综述，以期为研究糖尿病角膜病变的机制和治疗提供新的思路。

糖尿病/并发症;糖尿病角膜病变;炎症小体/代谢;核苷酸结合寡聚化结构域样受体蛋白3
ABSTRACT

Diabetic keratopathy is a chronic complication of diabetes caused by abnormal metabolites accumulation, oxidative stress, abnormal inflammation and corneal neuropathy.It can result in delayed corneal epithelial healing and decreased corneal sensitivity under the stimulation of ocular trauma or surgery which bring great challenges to clinicians.Activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammatory is one of the factors that cause chronic complications of diabetes, and is also an important factor for delaying the healing of diabetic wounds.The NLRP3 inflammatory signaling pathway is closely related to corneal oxidative stress, delayed epithelium healing and development of corneal neuropathy.In this paper, the research status and prospects of NLRP3 inflammatory signaling pathway and diabetic keratopathy were reviewed to provide new ideas for studying the mechanism and treatment of diabetic keratopathy.

Diabetes/complications;Diabetic keratopathy;Inflammasomes/metabolism;Nucleotide-binding oligomerization domain-like receptor protein 3
Xie Lixin, Email: mocdef.labiamtoheix_nixil
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引用本文

万鲁芹,周庆军,谢立信. NLRP3炎症小体信号通路在糖尿病角膜病变发生和发展中的作用[J]. 中华实验眼科杂志,2022,40(07)：680-684.

DOI:10.3760/cma.j.cn115989-20190618-00266

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糖尿病是多病因引起的以高血糖为特征的慢性疾病，其发病率逐渐升高。预测到2045年全球成人糖尿病患者总数将达到6.29亿 [ 1 ]。长期高血糖可导致糖尿病视网膜病变(diabetic retinopathy，DR)、糖尿病角膜病变(diabetic keratopathy，DK)等眼科并发症的发生，对视力及视功能造成严重影响 [ 2 ]。60%~70%的糖尿病患者会发生DK [ 3 ]，DK通常没有症状，但在眼外伤或手术后出现角膜上皮愈合延迟等表现，给临床医生带来极大的挑战。目前DK的发病机制尚不完全明确，可能与异常炎症、氧化应激及神经损伤等有关 [ 4 , 5 ]。研究发现抗炎治疗可改善DK患者的角膜上皮延迟愈合及促进神经修复 [ 6 ]。核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3，NLRP3)炎症小体作为机体固有免疫反应组成部分可能在DK的发展中起促进作用。NLRP3炎症小体活化后参与炎症反应，但活化失调会导致神经退行性疾病、2型糖尿病等发生，并参与糖尿病慢性并发症的发展 [ 7 , 8 ]，其持续激活可引发慢性炎症导致糖尿病患者伤口延迟愈合。NLRP3炎症小体信号通路相关因子在DK中已有涉及，本文针对其与DK的研究现状及前景进行综述，以期为进一步研究DK的机制和治疗提供方向。
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备注信息
A
谢立信，Email： mocdef.labiamtoheix_nixil
B
所有作者均声明不存在利益冲突
C
山东第一医科大学学术提升计划项目 (2019ZL001)
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