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血红蛋白氧载体增强肿瘤治疗效果研究进展
杨晓倩
陈绍水
作者及单位信息
·
DOI： 10.3760/cma.j.issn.1007-1245.2022.18.034
Research progress of hemoglobin oxygen carriers in increasing the therapeutic effect of tumors
Yang Xiaoqian
Chen Shaoshui
Authors Info & Affiliations
Yang Xiaoqian
Oncology Department, Binzhou Medical University Hospital, Binzhou 256600, China
Chen Shaoshui
Oncology Department, Binzhou Medical University Hospital, Binzhou 256600, China
·
DOI： 10.3760/cma.j.issn.1007-1245.2022.18.034
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摘要

肿瘤细胞异常增殖所形成的缺氧微环境导致当前多种抗癌治疗效果不够理想，且加速恶性进展，增加转移。在实体瘤中，充足的氧气供应对于提高抗肿瘤治疗的敏感性是至关重要的。具有携氧功能的血红蛋白氧载体（HBOCs）能有效缓解肿瘤缺氧，并与当前多种肿瘤临床治疗手段联用，取得了良好的效果。本文通过对近5年来HBOCs研究进展及其在缓解肿瘤缺氧、增强肿瘤治疗效果方面的应用进行综述，为临床肿瘤治疗提供参考。

血红蛋白;氧载体;肿瘤缺氧;肿瘤治疗
ABSTRACT

The hypoxic microenvironment formed by the abnormal proliferation of tumor cells leads to the unsatisfactory effect of various anti-cancer treatments, which accelerates the malignant progression and increases the metastasis. In solid tumors, adequate O 2 supply is crucial to improving the sensitivity of antitumor therapy. Hemoglobin oxygen carriers (HBOCs) with oxygen-carrying function can effectively alleviate the tumor hypoxia and have achieved good results in combination with a variety of current clinical tumor treatment methods. This paper reviews the research progress of HBOCs in recent 5 years and their application in alleviating the tumor hypoxia and increasing the curative effect of tumor treatment, to provide a reference for clinical tumor treatment.

Hemoglobin;Oxygen carrier;Tumor hypoxia;Tumor treatment
Chen Shaoshui, Email: mocdef.6ab21ssnehcyfyb
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引用本文

杨晓倩,陈绍水. 血红蛋白氧载体增强肿瘤治疗效果研究进展[J]. 国际医药卫生导报,2022,28(18)：2659-2663.

DOI:10.3760/cma.j.issn.1007-1245.2022.18.034

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肿瘤是当今对人类寿命及生活质量影响最大的疾病之一，因此迫切需要有效的治疗策略。然而由于肿瘤微环境（TME）的影响，现有治疗措施并没有达到人们对肿瘤治疗效果好、生存率高、不良反应小、预后好的期望。缺氧是实体恶性肿瘤的常见和重要特征。肿瘤缺氧微环境与肿瘤进展、侵袭性增加、转移潜力增强、肿瘤的转移密切相关。另外，缺氧还能增加肿瘤对放化疗等非手术治疗的抵抗 ［ 1 , 2 ］ 。因此，增加肿瘤细胞含氧量对提高治疗效果并抑制肿瘤生长和转移有着重要意义。现如今，在世界范围内多种改善肿瘤缺氧的措施已被开发并在肿瘤治疗领域取得一定成果。具有携氧功能的血红蛋白氧载体（HBOCs）一直是提高组织氧含量的研究热点，它具有保质期长、无需交叉配血、污染风险低等优点，最初被用作血液替代品，然而越来越多的研究表明HBOCs也有助于增加肿瘤氧合及放化疗等抗肿瘤治疗的敏感性，为缓解肿瘤缺氧提供了新的方法。随着对其研究的不断深入，现已取得了许多新的进展。本文将对近5年来HBOCs研究进展及其在缓解肿瘤缺氧、增强肿瘤治疗效果方面的应用进行综述，为临床肿瘤治疗提供参考。
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备注信息
A
陈绍水，Email： mocdef.6ab21ssnehcyfyb
B

杨晓倩, 陈绍水. 血红蛋白氧载体增强肿瘤治疗效果研究进展[J]. 国际医药卫生导报, 2022, 28(18): 2659-2663. DOI: 10.3760/cma.j.issn.1007-1245.2022.18.034.

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