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固有淋巴细胞与心血管疾病的研究进展
卢文超
冯颖青
朱亦橙
作者及单位信息
·
DOI： 10.3760/cma.j.cn112148-20211019-00898
Research advances on the association between innate lymphoid cells and cardiovascular diseases
Lu Wenchao
Feng Yingqing
Zhu Yicheng
Authors Info & Affiliations
Lu Wenchao
Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China
Feng Yingqing
Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Department of Cardiology, Guangdong Provincial People′s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Zhu Yicheng
Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Department of Cardiology, Guangdong Provincial People′s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
·
DOI： 10.3760/cma.j.cn112148-20211019-00898
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摘要

2012年发现了一类新型免疫细胞——固有淋巴细胞，已有大量研究阐明了其的分型、发育分化机制、免疫功能以及其在肠道、气道、皮肤和脂肪炎症中的重要作用。近年来研究发现固有淋巴细胞在心血管疾病中也能发挥着重要作用，该文对固有淋巴细胞的特征、功能及其在心血管疾病中的研究进展进行了综述。

心血管疾病;淋巴细胞;免疫;炎症
引用本文

卢文超,冯颖青,朱亦橙. 固有淋巴细胞与心血管疾病的研究进展[J]. 中华心血管病杂志,2022,50(10)：1029-1033.

DOI:10.3760/cma.j.cn112148-20211019-00898

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固有淋巴细胞（innate lymphoid cells，ILC）大多为组织驻留细胞，在保护上皮屏障免受感染和介导组织器官免疫炎症方面具有重要作用 ［ 1 , 2 ］ 。根据细胞的发育和功能可将ILC分为5个亚群，即自然杀伤（nature killer，NK）细胞、1型ILC（ILC1）、2型ILC（ILC2）、3型ILC（ILC3）和淋巴组织诱导细胞（lymphoid tissue inducer cells，LTi） ［ 3 , 4 , 5 ］ 。此外，个别研究还发现ILC中存在调节性固有淋巴细胞（ILCsreg），其可在肠道中分泌白细胞介素（interleukin，IL）-10 ［ 6 ］ ，但该亚群的归类和功能仍存在争议 ［ 7 ］ 。ILC不仅在皮肤、肺部、肠道、脂肪等组织或器官的免疫炎症反应中发挥着重要作用，近年来其在心血管疾病中的作用和机制研究也取得了重要进展。本文对ILC的特征和功能及其在心血管疾病中的研究进展进行了综述。
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备注信息
A
朱亦橙，Email： nc.defgrabo.hpdggnehciyuhz
B

卢文超, 冯颖青, 朱亦橙. 固有淋巴细胞与心血管疾病的研究进展[J]. 中华心血管病杂志, 2022, 50(10): 1029-1033. DOI: 10.3760/cma.j.cn112148-20211019-00898.

C
所有作者声明无利益冲突
D
国家自然科学基金 (8210020906)
广东省基础与应用基础研究基金 (2020A1515010738)
高层次人才团队建设项目 (Y012018085)
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