高级检索
中华实验眼科杂志
期刊首页
过刊列表
高级检索
稿件发表
• 综述 •
ENGLISH ABSTRACT
雷帕霉素对增生性玻璃体视网膜病变的保护作用研究进展
廖梦宇
颜华 [综述]
作者及单位信息
·
DOI： 10.3760/cma.j.cn115989-20200203-00048
Research progress of the protection of rapamycin for proliferative vitreoretinopathy
Liao Mengyu
Yan Hua
Authors Info & Affiliations
Liao Mengyu
Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin Key Laboratory of Ocular Trauma and Laboratory of Molecular Ophthalmology, Tianjin Medical University, Tianjin 300070, China
Yan Hua
Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin Key Laboratory of Ocular Trauma and Laboratory of Molecular Ophthalmology, Tianjin Medical University, Tianjin 300070, China
·
DOI： 10.3760/cma.j.cn115989-20200203-00048
0
0
0
0
0
0
PDF下载
APP内阅读
摘要

增生性玻璃体视网膜病变(PVR)是眼外伤、孔源性视网膜脱离(RRD)等的并发症，也是造成RRD复位手术失败的常见原因。视网膜色素上皮(RPE)细胞异常增生、迁移和上皮间充质化在PVR相关的视网膜前增生膜的形成中起着主导作用。雷帕霉素是哺乳动物雷帕霉素靶蛋白(mTOR)的特异性抑制剂，选择性地结合细胞蛋白FKBP-12，和FKBP-雷帕霉素相关蛋白(FRAP)的FKBP12-雷帕霉素结构域(FRB)直接结合变构从而抑制mTOR活性。雷帕霉素具有多种衍生物和类似物，通过对mTOR信号转导途径的抑制发挥抑制细胞增生和调节细胞周期等作用，在PVR中对RPE细胞异常增生、迁移和上皮间充质化起到一定的抑制作用，对PVR中胶质细胞的修复、炎症细胞的抑制和血管内皮细胞的损伤也起到一定保护作用。近年来，雷帕霉素在多种眼病中的临床试验不断开展，对其在眼部给药方式的探索和用药安全性方面的证据逐渐全面。本文就雷帕霉素对PVR中RPE细胞及其他细胞的保护作用、用药安全性等方面作一综述。

雷帕霉素;哺乳动物雷帕霉素靶蛋白;视网膜;增生性玻璃体视网膜病变
ABSTRACT

Proliferative vitreoretinopathy (PVR) is a complication of ocular trauma, rhegmatogenous retinal detachment (RRD), and also a common cause of RRD repair surgery failure.Abnormal proliferation, migration and epithelial mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells play a leading role in the formation of PVR epiretinal membrane.Rapamycin is the specific inhibitor of mammalian target of rapamycin (mTOR). It selectively binds to the cell protein FKBP-12 and directly binds to the FKBP12-rapamycin domain (FRB) of FKBP rapamycin associated protein (FRAP) to inhibit mTOR activity.Rapamycin has a variety of rapalog (rapamycin analog), which inhibits cell proliferation and regulate cell cycle by inhibiting mTOR signal transduction pathway.It also plays a certain role in inhibiting RPE cell abnormal proliferation, migration and EMT in PVR, and protecting the repair of glial cells, inhibiting the inflammatory cells and preventing the vascular endothelial cell damage.In recent years, the clinical trials and drug studies have shown the important role of rapamycin in ocular diseases.In addition, the evidence on ocular administrations and drug safety of rapamycin has been gradually accumulated.This article reviewed the protective effects and safety of rapamycin on RPE cells and other cells in PVR.

Rapamycin;Mammalian target of rapamycin;Retina;Proliferative vitreoretinopathy
Yan Hua, Email: nc.defudabe.umtauhnayyyz
Copyright by Chinese Medical Association
No content published by the journals of Chinese Medical Association may be reproduced or abridged without authorization. Please do not use or copy the layout and design of the journals without permission.
All articles published represent the opinions of the authors, and do not reflect the official policy of the Chinese Medical Association or the Editorial Board, unless this is clearly specified.
引用本文

廖梦宇,颜华. 雷帕霉素对增生性玻璃体视网膜病变的保护作用研究进展[J]. 中华实验眼科杂志,2023,41(01)：88-91.

DOI:10.3760/cma.j.cn115989-20200203-00048

PERMISSIONS

Request permissions for this article from CCC.

评价本文
*以上评分为匿名评价

版权归中华医学会所有。

未经授权，不得转载、摘编本刊文章，不得使用本刊的版式设计。

除非特别声明，本刊刊出的所有文章不代表中华医学会和本刊编委会的观点。

增生性玻璃体视网膜病变(proliferative vitreoretinopathy，PVR)是眼外伤、孔源性视网膜脱离(rhegmatogenous retinal detachment，RRD)等的并发症，主要表现为玻璃体后表面及视网膜表面大量纤维增生膜形成，这些增生膜组织收缩、牵拉视网膜，导致继发性视网膜脱离或出血，严重影响患者视力[ 1 , 2 ]。PVR也是造成RRD复位手术失败的常见原因[ 3 , 4 ]。参与PVR形成的细胞主要包括视网膜色素上皮(retinal pigment epithelium，RPE)细胞、视网膜胶质细胞、巨噬细胞、纤维细胞和肌纤维细胞。其中，RPE细胞在PVR相关的视网膜前膜的形成中起着主导作用[ 5 , 6 , 7 , 8 ]。雷帕霉素(rapamycin)作为哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin，mTOR)抑制剂已被证实在多种增生性眼病中发挥重要作用。本文就雷帕霉素与mTOR信号通路，并分别对RPE细胞的异常增生、迁移和上皮间充质转化(epithelial-mesenchymal transition，EMT)的抑制作用和对细胞周期的调控作用在PVR中所起保护作用的相关机制研究进展作一综述。
试读结束，您可以通过登录机构账户或个人账户后获取全文阅读权限。
参考文献
[1]
Pastor JC , Rojas J , Pastor-Idoate S ，et al. Proliferative vitreoretinopathy：a new concept of disease pathogenesis and practical consequences[J]．Prog Retin Eye Res， 2016，51:125-155. doi: 10.1016/j.preteyeres.2015.07.005 .
返回引文位置Google Scholar
百度学术
万方数据
[2]
Wiedemann P , Bringmann A ．Proliferative vitreoretinopathy[J]．Klin Monbl Augenheilkd， 2016，233(9):1012-1015. doi: 10.1055/s-0042-109704 .
返回引文位置Google Scholar
百度学术
万方数据
[3]
Haugstad M , Moosmayer S , Bragadóttir R ．Primary rhegmatogenous retinal detachment-surgical methods and anatomical outcome[J]．Acta Ophthalmol， 2017，95(3):247-251. doi: 10.1111/aos.13295 .
返回引文位置Google Scholar
百度学术
万方数据
[4]
Lumi X , Lužnik Z , Petrovski G ，et al. Anatomical success rate of pars plana vitrectomy for treatment of complex rhegmatogenous retinal detachment[J/OL]．BMC Ophthalmol， 2016，16(1):216[2022-05-10]. http://www.ncbi.nlm.nih.gov/pubmed/27938367. doi: 10.1186/s12886-016-0390-2 .
返回引文位置Google Scholar
百度学术
万方数据
[5]
Qin D , Zhang L , Jin X ，et al. Effect of Endothelin-1 on proliferation，migration and fibrogenic gene expression in human RPE cells[J]．Peptides， 2017，94:43-48. doi: 10.1016/j.peptides.2017.06.004 .
返回引文位置Google Scholar
百度学术
万方数据
[6]
Frisina R , Tessarolo F , Marchesoni I ，et al. Microscopic observation of proliferative membranes in fibrocontractive retinal disorders[J/OL]．J Ophthalmol， 2019，2019:9647947[2022-05-10]. http://www.ncbi.nlm.nih.gov/pubmed/31467697. doi: 10.1155/2019/9647947 .
返回引文位置Google Scholar
百度学术
万方数据
[7]
Brown KR , Dubovy SR , Relhan N ，et al. Clinicopathologic correlation of a subretinal proliferative vitreoretinopathy band in a patient with chronic recurrent retinal detachment[J]．Case Rep Ophthalmol， 2018，9(2):279-282. doi: 10.1159/000488931 .
返回引文位置Google Scholar
百度学术
万方数据
[8]
Mudhar HS . A brief review of the histopathology of proliferative vitreoretinopathy (PVR)[J]．Eye (Lond)， 2020，34(2):246-250. doi: 10.1038/s41433-019-0724-4 .
返回引文位置Google Scholar
百度学术
万方数据
[9]
Vézina C , Kudelski A , Sehgal SN . Rapamycin (AY-22，989)，a new antifungal antibiotic.I.Taxonomy of the producing streptomycete and isolation of the active principle[J]．J Antibiot (Tokyo)， 1975，28(10):721-726. doi: 10.7164/antibiotics.28.721 .
返回引文位置Google Scholar
百度学术
万方数据
[10]
Ventura-Aguiar P , Campistol JM , Diekmann F ．Safety of mTOR inhibitors in adult solid organ transplantation[J]．Expert Opin Drug Saf， 2016，15(3):303-319. doi: 10.1517/14740338.2016.1132698 .
返回引文位置Google Scholar
百度学术
万方数据
[11]
Bak S , Tischer S , Dragon A ，et al. Selective effects of mTOR inhibitor sirolimus on naïve and CMV-specific T cells extending its applicable range beyond immunosuppression[J/OL]．Front Immunol， 2018，9:2953[2022-05-16]. http://www.ncbi.nlm.nih.gov/pubmed/30619313. doi: 10.3389/fimmu.2018.02953 .
返回引文位置Google Scholar
百度学术
万方数据
[12]
Bai D , Zhao Y , Zhu Q ，et al. LZ205，a newly synthesized flavonoid compound，exerts anti-inflammatory effect by inhibiting M1 macrophage polarization through regulating PI3K/AKT/mTOR signaling pathway[J]．Exp Cell Res， 2018，364(1):84-94. doi: 10.1016/j.yexcr.2018.01.033 .
返回引文位置Google Scholar
百度学术
万方数据
[13]
Hua H , Zhu Y , Song YH . Ruscogenin suppressed the hepatocellular carcinoma metastasis via PI3K/Akt/mTOR signaling pathway[J]．Biomed Pharmacother， 2018，101:115-122. doi: 10.1016/j.biopha.2018.02.031 .
返回引文位置Google Scholar
百度学术
万方数据
[14]
Wang L , Li X , Yang Z ，et al. Crotonaldehyde induces autophagy-mediated cytotoxicity in human bronchial epithelial cells via PI3K，AMPK and MAPK pathways[J]．Environ Pollut， 2017，228:287-296. doi: 10.1016/j.envpol.2017.03.083 .
返回引文位置Google Scholar
百度学术
万方数据
[15]
Wu C , Qiu S , Liu P ，et al. Rhizoma amorphophalli inhibits TNBC cell proliferation，migration，invasion and metastasis through the PI3K/Akt/mTOR pathway[J]．J Ethnopharmacol， 2018，211:89-100. doi: 10.1016/j.jep.2017.09.033 .
返回引文位置Google Scholar
百度学术
万方数据
[16]
Ersahin T , Tuncbag N , Cetin-Atalay R ．The PI3K/AKT/mTOR interactive pathway[J]．Mol Biosyst， 2015，11(7):1946-1954. doi: 10.1039/c5mb00101c .
返回引文位置Google Scholar
百度学术
万方数据
[17]
Roohi A , Hojjat-Farsangi M ．Recent advances in targeting mTOR signaling pathway using small molecule inhibitors[J]．J Drug Target， 2017，25(3):189-201. doi: 10.1080/1061186X.2016.1236112 .
返回引文位置Google Scholar
百度学术
万方数据
[18]
Garweg JG , Tappeiner C , Halberstadt M ．Pathophysiology of proliferative vitreoretinopathy in retinal detachment[J]．Surv Ophthalmol， 2013，58(4):321-329. doi: 10.1016/j.survophthal.2012.12.004 .
返回引文位置Google Scholar
百度学术
万方数据
[19]
Yang S , Li H , Li M ，et al. Mechanisms of epithelial-mesenchymal transition in proliferative vitreoretinopathy[J]．Discov Med， 2015，20(110):207-217.
返回引文位置Google Scholar
百度学术
万方数据
[20]
Palma-Nicolas JP , López E , López-Colomé AM . PKC isoenzymes differentially modulate the effect of thrombin on MAPK-dependent RPE proliferation[J]．Biosci Rep， 2008，28(6):307-317. doi: 10.1042/BSR20080083 .
返回引文位置Google Scholar
百度学术
万方数据
[21]
Cai N , Dai SD , Liu NN ，et al. PI3K/AKT/mTOR signaling pathway inhibitors in proliferation of retinal pigment epithelial cells[J]．Int J Ophthalmol， 2012，5(6):675-680. doi: 10.3980/j.issn.2222-3959.2012.06.05 .
返回引文位置Google Scholar
百度学术
万方数据
[22]
Kuo HK , Chen YH , Kuo YH ，et al. Evaluation of the effect of everolimus on retinal pigment epithelial cells and experimental proliferative vitreoretinopathy[J]．Curr Eye Res， 2018，43(3):333-339. doi: 10.1080/02713683.2017.1396618 .
返回引文位置Google Scholar
百度学术
万方数据
[23]
侯敏，刘红玲，尹增伟，等．雷帕霉素对人视网膜色素上皮细胞增生和凋亡的影响[J]．中华实验眼科杂志， 2011，29(10):879-883. doi: 10.3760/cma.j.issn.2095-0160.2011.10.004 .
返回引文位置Google Scholar
百度学术
万方数据
Hou M , Liu HL , Yin ZW ，et al. The effects of rapamycin on the proliferation and apoptosis of human retinal pigment epithelium cells in vitro[J]．Chin J Exp Ophthalmol， 2011，29(10):879-883. doi: 10.3760/cma.j.issn.2095-0160.2011.10.004 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[24]
Yang SF , Chen YS , Chien HW ，et al. Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells：implications for proliferative vitreoretinopathy[JOL]．J Pineal Res， 2020，68(1):e12615[2022-12-21]. http://www.ncbi.nlm.nih.gov/pubmed/31605630. doi: 10.1111/jpi.12615 .
返回引文位置Google Scholar
百度学术
万方数据
[25]
Liu NN , Zhao N , Cai N ．Suppression of the proliferation of hypoxia-induced retinal pigment epithelial cell by rapamycin through the/mTOR/HIF-1α/VEGF/signaling[J]．IUBMB Life， 2015，67(6):446-452. doi: 10.1002/iub.1382 .
返回引文位置Google Scholar
百度学术
万方数据
[26]
Ciprian D ．The pathogeny of proliferative vitreoretinopathy[J]．Rom J Ophthalmol， 2015，59(2):88-92.
返回引文位置Google Scholar
百度学术
万方数据
[27]
Liu Y , Cao GF , Xue J ，et al. Tumor necrosis factor-alpha (TNF-α)-mediated in vitro human retinal pigment epithelial (RPE) cell migration mainly requires Akt/mTOR complex 1 (mTORC1)，but not mTOR complex 2 (mTORC2) signaling[J]．Eur J Cell Biol， 2012，91(9):728-737. doi: 10.1016/j.ejcb.2012.03.008 .
返回引文位置Google Scholar
百度学术
万方数据
[28]
Wang CH , Cao GF , Jiang Q ，et al. TNF-α promotes human retinal pigment epithelial (RPE) cell migration by inducing matrix metallopeptidase 9 (MMP-9) expression through activation of Akt/mTORC1signaling[J]．Biochem Biophys Res Commun， 2012，425(1):33-38. doi: 10.1016/j.bbrc.2012.07.044 .
返回引文位置Google Scholar
百度学术
万方数据
[29]
Zhou P , Zhao MW , Li XX ，et al. siRNA targeting mammalian target of rapamycin (mTOR) attenuates experimental proliferative vitreoretinopathy[J]．Curr Eye Res， 2007，32(11):973-984. doi: 10.1080/02713680701658323 .
返回引文位置Google Scholar
百度学术
万方数据
[30]
Calton MA , Vollrath D ．The mTOR kinase inhibitor INK128 blunts migration of cultured retinal pigment epithelial cells[J]．Adv Exp Med Biol， 2016，854:709-715. doi: 10.1007/978-3-319-17121-0_94 .
返回引文位置Google Scholar
百度学术
万方数据
[31]
Cao GF , Liu Y , Yang W ，et al. Rapamycin sensitive mTOR activation mediates nerve growth factor (NGF) induced cell migration and pro-survival effects against hydrogen peroxide in retinal pigment epithelial cells[J]．Biochem Biophys Res Commun， 2011，414(3):499-505. doi: 10.1016/j.bbrc.2011.09.094 .
返回引文位置Google Scholar
百度学术
万方数据
[32]
Yang L , Yu P , Chen M ，et al. Mammalian target of rapamycin inhibitor rapamycin alleviates 7-ketocholesterol induced inflammatory responses and vascular endothelial growth factor elevation by regulating MAPK pathway in human retinal pigment epithelium cells[J]．J Ocul Pharmacol Ther， 2022，38(2):189-200. doi: 10.1089/jop.2021.0082 .
返回引文位置Google Scholar
百度学术
万方数据
[33]
Matoba R , Morizane Y , Shiode Y ，et al. Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells[J/OL]．PLoS One， 2017，12(7):e0181481[2022-05-22]. http://www.ncbi.nlm.nih.gov/pubmed/28719670. doi: 10.1371/journal.pone.0181481 .
返回引文位置Google Scholar
百度学术
万方数据
[34]
Madrakhimov SB , Yang JY , Park HY ，et al. Essential role of mTOR signaling in human retinal pigment epithelial cell regeneration after laser photocoagulation[J]．Lasers Med Sci， 2019，34(5):1019-1029. doi: 10.1007/s10103-018-2692-5 .
返回引文位置Google Scholar
百度学术
万方数据
[35]
Kolosova NG , Muraleva NA , Zhdankina AA ，et al. Prevention of age-related macular degeneration-like retinopathy by rapamycin in rats[J]．Am J Pathol， 2012，181(2):472-477. doi: 10.1016/j.ajpath.2012.04.018 .
返回引文位置Google Scholar
百度学术
万方数据
[36]
Jiang C , Qin B , Liu G ，et al. MicroRNA-184 promotes differentiation of the retinal pigment epithelium by targeting the AKT2/mTOR signaling pathway[J/OL]．Oncotarget， 2016，7(32):52340-52353[2022-05-22]. http://www.ncbi.nlm.nih.gov/pubmed/27418134. doi: 10.18632/oncotarget.10566 .
返回引文位置Google Scholar
百度学术
万方数据
[37]
Demidenko ZN , Zubova SG , Bukreeva EI ，et al. Rapamycin decelerates cellular senescence[J]．Cell Cycle， 2009，8(12):1888-1895. doi: 10.4161/cc.8.12.8606 .
返回引文位置Google Scholar
百度学术
万方数据
[38]
Chen H , Wang H , An J ，et al. Plumbagin induces RPE cell cycle arrest and apoptosis via p38 MARK and PI3K/AKT/mTOR signaling pathways in PVR[J/OL]．BMC Complement Altern Med， 2018，18(1):89[2022-05-22]. http://www.ncbi.nlm.nih.gov/pubmed/29534723. doi: 10.1186/s12906-018-2155-3 .
返回引文位置Google Scholar
百度学术
万方数据
[39]
Apontes P , Leontieva OV , Demidenko ZN ，et al. Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture[J]．Oncotarget， 2011，2(3):222-233. doi: 10.18632/oncotarget.248 .
返回引文位置Google Scholar
百度学术
万方数据
[40]
Zhao C , Yasumura D , Li X ，et al. mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice[J]．J Clin Invest， 2011，121(1):369-383. doi: 10.1172/JCI44303 .
返回引文位置Google Scholar
百度学术
万方数据
[41]
Lewis GP , Chapin EA , Byun J ，et al. Muller cell reactivity and photoreceptor cell death are reduced after experimental retinal detachment using an inhibitor of the Akt/mTOR pathway[J]．Invest Ophthalmol Vis Sci， 2009，50(9):4429-4435. doi: 10.1167/iovs.09-3445 .
返回引文位置Google Scholar
百度学术
万方数据
[42]
Liegl R , Koenig S , Siedlecki J ，et al. Temsirolimus inhibits proliferation and migration in retinal pigment epithelial and endothelial cells via mTOR inhibition and decreases VEGF and PDGF expression[J/OL]．PLoS One， 2014，9(2):e88203[2022-05-30]. http://www.ncbi.nlm.nih.gov/pubmed/24586308. doi: 10.1371/journal.pone.0088203 .
返回引文位置Google Scholar
百度学术
万方数据
[43]
Wong WT , Dresner S , Forooghian F ，et al. Treatment of geographic atrophy with subconjunctival sirolimus：results of a phase Ⅰ/Ⅱ clinical trial[J]．Invest Ophthalmol Vis Sci， 2013，54(4):2941-2950. doi: 10.1167/iovs.13-11650 .
返回引文位置Google Scholar
百度学术
万方数据
[44]
Krishnadev N , Forooghian F , Cukras C ，et al. Subconjunctival sirolimus in the treatment of diabetic macular edema[J]．Graefes Arch Clin Exp Ophthalmol， 2011，249(11):1627-1633. doi: 10.1007/s00417-011-1694-9 .
返回引文位置Google Scholar
百度学术
万方数据
[45]
Sen HN , Larson TA , Meleth AD ，et al. Subconjunctival sirolimus for the treatment of chronic active anterior uveitis：results of a pilot trial[J]．Am J Ophthalmol， 2012，153(6):1038-1042. doi: 10.1016/j.ajo.2011.12.018 .
返回引文位置Google Scholar
百度学术
万方数据
[46]
Nguyen QD , Ibrahim MA , Watters A ，et al. Ocular tolerability and efficacy of intravitreal and subconjunctival injections of sirolimus in patients with non-infectious uveitis：primary 6-month results of the SAVE Study[J/OL]．J Ophthalmic Inflamm Infect， 2013，3(1):32[2022-06-01]. http://www.ncbi.nlm.nih.gov/pubmed/23514595. doi: 10.1186/1869-5760-3-32 .
返回引文位置Google Scholar
百度学术
万方数据
[47]
Ibrahim MA , Sepah YJ , Watters A ，et al. One-year outcomes of the SAVE Study：sirolimus as a therapeutic approach for uveitis[J/OL]．Transl Vis Sci Technol， 2015，4(2):4[2022-06-01]. http://www.ncbi.nlm.nih.gov/pubmed/25774330. doi: 10.1167/tvst.4.2.4 .
返回引文位置Google Scholar
百度学术
万方数据
[48]
Wu W , He Z , Zhang Z ，et al. Intravitreal injection of rapamycin-loaded polymeric micelles for inhibition of ocular inflammation in ratmodel[J]．Int J Pharm. 2016，513(1-2):238-246. doi: 10.1016/j.ijpharm.2016.09.013 .
返回引文位置Google Scholar
百度学术
万方数据
[49]
Cholkar K , Gunda S , Earla R ，et al. Nanomicellar topical aqueous drop formulation of rapamycin for back-of-the-eye delivery[J]．AAPS PharmSciTech， 2015，16(3):610-622. doi: 10.1208/s12249-014-0244-2 .
返回引文位置Google Scholar
百度学术
万方数据
备注信息
A
颜华，Email：nc.defudabe.umtauhnayyyz
B
所有作者均声明不存在任何利益冲突
C
国家自然科学基金项目 (81830026)
评论 （0条）
注册
登录
时间排序
暂无评论，发表第一条评论抢沙发
MedAI助手（体验版）
文档即答
智问智答
机器翻译
回答内容由人工智能生成，我社无法保证其准确性和完整性，该生成内容不代表我们的态度或观点，仅供参考。
生成快照
文献快照

你好，我可以帮助您更好的了解本文，请向我提问您关注的问题。

0/2000

《中华医学会杂志社用户协议》 | 《隐私政策》

《SparkDesk 用户协议》 | 《SparkDesk 隐私政策》

网信算备340104764864601230055号 | 网信算备340104726288401230013号

技术支持：

历史对话
本文全部
还没有聊天记录
设置
模式
纯净模式沉浸模式
字号
小中大