专家建议与推荐
ENGLISH ABSTRACT
周边虹膜切除联合房角分离及房角切开术操作规范专家推荐意见
张秀兰
林凤彬
范肃洁
唐莉
唐广贤
谢琳
卢岚
原慧萍
聂昕
作者及单位信息
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DOI: 10.3760/cma.j.cn115989-20221127-00552
Expert recommendations of surgical technique for peripheral iridectomy with goniosynechialysis and goniotomy
Zhang Xiulan
Lin Fengbin
Fan Sujie
Tang Li
Tang Guangxian
Xie Lin
Lu Lan
Yuan Huiping
Nie Xin
Authors Info & Affiliations
Zhang Xiulan
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China
Lin Fengbin
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China
Fan Sujie
Handan City Eye Hospital, Handan 056001, China
Tang Li
Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, China
Tang Guangxian
Department of Ophthalmology, Shijiazhuang People's Hospital, Shijiazhuang 050000, China
Xie Lin
Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China
Lu Lan
Department of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou 350001, China
Yuan Huiping
Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin 150086, China
Nie Xin
Department of Ophthalmology, People's Hospital of Chongqing, Chongqing 400014, China
·
DOI: 10.3760/cma.j.cn115989-20221127-00552
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摘要

微创青光眼手术(MIGS)近年来在临床上得到广泛开展,其在治疗原发性闭角型青光眼(PACG)中的作用也逐渐突显。周边虹膜切除(SPI)联合房角分离(GSL)及房角切开术(GT)作为新型的微创联合术式,目前被证实在治疗合并透明晶状体或没有白内障手术指征的中晚期PACG中是安全、有效的,目前在临床上已用于青光眼患者的治疗,但其手术操作及围手术期用药仍缺乏统一的规范,影响了治疗效果的正确评价。国内部分青光眼治疗专家针对目前SPI联合GSL及GT治疗PACG应用中存在的问题制定详细、完整的规范专家推荐意见,包括手术适应证、麻醉方法、手术部位、手术步骤、围手术期用药方法,以规范临床医生应用该技术治疗PACG的医疗过程,为更好地评价MIGS疗效奠定基础。

原发性闭角型青光眼;微创青光眼手术;周边虹膜切除术;房角分离术;房角切开术;推荐意见
ABSTRACT

Minimally invasive glaucoma surgery (MIGS) has been successfully incorporated in clinical practice in recent years.Increasing evidence shows that MIGS also plays an increasingly important role in the treatment of primary angle-closure glaucoma (PACG). Surgical peripheral iridectomy (SPI) plus goniosynechialysis (GSL) and goniotomy (GT), as a new procedure, has been proven to be safe and effective in the treatment of PACG with no or mild cataracts.However, there is still a lack of uniform standards for indications, surgical procedures, and perioperative medication.Therefore, it is necessary to formulate a detailed and complete expert recommendations on surgical procedures to standardize the application of combined SPI+ GSL+ GT in the treatment.Some experts in glaucoma treatment and management in China have discussed the current problems and developing trend in MIGS for PACG and put forward the expert recommendations of standard process, including indications, anaesthetic methods, surgical site, operating procedure and rational administration of drugs in perioperation, in order to standardize the medical process of clinicians using combined SPI+ GSL+ GT in PACG treatment and lay a foundation for better evaluation of the efficacy of MIGS.

Primary angle-closure glaucoma;Minimally invasive glaucoma surgery;Surgical peripheral iridectomy;Goniosynechialysis;Goniotomy;Expert recoomendation
Zhang Xiulan, Email: nc.defudabe.usys.liam2lxgnahz
引用本文

张秀兰,林凤彬,范肃洁,等. 周边虹膜切除联合房角分离及房角切开术操作规范专家推荐意见[J]. 中华实验眼科杂志,2023,41(02):101-103.

DOI:10.3760/cma.j.cn115989-20221127-00552

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青光眼是全球首位不可逆性致盲眼病,其致盲患者中约50%是原发性闭角型青光眼(primary angle-closure glaucoma,PACG)。我国PACG患病率及致盲率均较高,全球约50%的PACG病例在我国 [ 1 , 2 ]。手术是PACG的一线治疗方法,既往针对合并透明晶状体或没有白内障手术指征的中晚期PACG的首选手术方案是小梁切除术 [ 3 , 4 ],但小梁切除术并发症较多,如创口较大、浅前房、持续性低眼压、角膜内皮失代偿、眼内炎、恶性青光眼以及滤过泡相关并发症等 [ 5 ],也存在医师学习曲线长、术后需要长期的精细处理等问题。因此,临床工作中对于一些特殊情况,如年轻、具有恶性青光眼特征的PACG患者,既往通常采用虹膜周边切除术(surgical peripheral iridectomy,SPI)联合术后降眼压药物替代治疗 [ 6 , 7 , 8 ]
微创青光眼手术(minimally invasive glaucoma surgery,MIGS)近年来在临床上得到广泛开展。SPI联合房角分离(goniosynechialysis,GSL)及房角切开术(goniotomy,GT)(同内路Schlemm切开术,ab interno trabeculotomy)作为一种新型的微创青光眼联合术式,通过SPI解除瞳孔阻滞,沟通前后房;GSL分离前粘连的虹膜,重新开放房角;GT切开病变小梁网组织,增加房水外流从而降低眼压 [ 9 ]。已有临床研究和临床实践表明其适用于合并透明晶状体或没有白内障手术指征的中晚期PACG的治疗 [ 10 , 11 , 12 , 13 ]。由于其手术操作简单、快捷、并发症少,有望替代小梁切除术并成为此类患者的优选手术方式。然而,随着SPI+GSL+GT手术的广泛开展,其手术操作、围手术期用药仍缺乏统一的规范。因此,制定一个完整详细的手术操作规范,为临床医生的相关实践提供专家指导意见非常有必要。为了规范SPI联合GSL及GT的治疗方法,国内部分青光眼治疗专家共同讨论并对目前相关治疗方法中存在的问题进行分析,提出SPI联合GSL及GT治疗PACG专家推荐意见。
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备注信息
A
张秀兰,Email: nc.defudabe.usys.liam2lxgnahz
B
本推荐意见内容与相关产品的生产和销售厂商无经济利益关系;本文仅为专家意见,为临床医疗服务提供指导,不是在各种情况下都必须遵循的医疗标准,也不是为个别特殊个人提供的保健措施;所有作者均声明不存在利益冲突
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