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ENGLISH ABSTRACT
青海西宁高原眼健康筛查人群眼压分布及参考区间
杨一佺
包云兰
孙云晓
谢媛
汪夏玲
刘优
谢延玲
郝洁
彭晓霞
范肃洁
吴世政
王宁利
作者及单位信息
·
DOI： 10.3760/cma.j.cn115989-20221004-00467
Intraocular pressure distribution and reference interval of high-altitude eye health screening population from Xining, Qinghai
Yang Yiquan
Bao Yunlan
Sun Yunxiao
Xie Yuan
Wang Xialing
Liu You
Xie Yanling
Hao Jie
Peng Xiaoxia
Fan Sujie
Wu Shizheng
Wang Ningli
Authors Info & Affiliations
Yang Yiquan
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China
Bao Yunlan
Department of Neurology, Qinghai Provincial People's Hospital, Xining 810007, China
Sun Yunxiao
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China
Xie Yuan
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China
Wang Xialing
Department of Neurology, Qinghai Provincial People's Hospital, Xining 810007, China
Liu You
Department of Neurology, Qinghai Provincial People's Hospital, Xining 810007, China
Xie Yanling
Department of Endocrinology, Qinghai Provincial People's Hospital, Xining 810007, China
Hao Jie
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China
Peng Xiaoxia
Clinical Epidemiology Research Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
Fan Sujie
Department of Glaucoma, Handan City Eye Hospital (The Third Hospital of Handan), Handan 056006, China
Wu Shizheng
Department of Neurology, Qinghai Provincial People's Hospital, Xining 810007, China
Wang Ningli
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China
·
DOI： 10.3760/cma.j.cn115989-20221004-00467
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摘要

目的探讨青海省西宁市高原地区18岁及以上人群眼压分布特征，建立青海西宁高原人群眼压值参考区间。

方法采用横断面研究方法，于2019年9月至2020年5月在青海省西宁市(海拔2.271 km)对青海省人民医院体检中心接受健康体检的受检者进行眼科检查及眼压测定。受检者均常居西宁市且近3个月未离开西宁市。眼科检查包括视力检查、眼压测定、裂隙灯显微镜检查、眼底照相及眼前后节光学相干断层扫描检查。眼压测定采用Goldmann压平眼压计在眼表局部麻醉下进行。排除有可引起眼压显著改变因素、有影响眼压测量准确性因素及无法行眼压测量者。依据性别、年龄和不同民族对受检者进行分组，比较各组眼压值分布及参考区间。

结果纳入体检者6 120人6 120眼，其中男2 850人，女3 270人；年龄18~90岁，平均(45.54±13.85)岁。青海西宁高原地区人群眼压平均值为(14.32±1.93)mmHg(1 mmHg＝0.133 kPa)，参考区间为10.54~18.10 mmHg；男性眼压平均值为(14.42±1.98)mmHg，参考区间为10.54~18.30 mmHg；女性眼压平均值为(14.23±1.88)mmHg，参考区间为10.55~17.91 mmHg，男性眼压值高于女性，差异有统计学意义(t＝3.71，P<0.001)。汉族、藏族、回族和其他民族人群眼压分别为(14.38±1.91)、(13.93±2.06)、(14.21±1.87)和(13.94±1.95)mmHg，总体比较差异有统计学意义(F＝6.73，P<0.001)，其中汉族受检者眼压值明显高于藏族、回族及其他少数民族，差异均有统计学意义(均P<0.05)。

结论青海西宁高原地区人群与正常海拔地区相比眼压参考区间偏低。

眼压;参考区间;高原人群;中央角膜厚度
ABSTRACT

ObjectiveTo investigate the distribution of intraocular pressure (IOP) in high-altitude population aged 18 years and over in Xining, Qinghai and establish the reference interval (RI) of IOP.

MethodsA cross-sectional study was conducted in Xining, Qinghai Province at 2.271 km above sea level from September 2019 to May 2020.Ophthalmic examinations and IOP measurement were conducted among subjects from Physical Examination Center of Qinghai Provincial People's Hospital.The subjects who had been living in Xining without leaving for three months were enrolled.Ophthalmic examinations included vision examination, IOP measurement, slit-lamp microscopy, fundus photography, anterior and posterior segment optical coherence tomography.IOP was measured using Goldmann applanation tonometry under local anesthesia.Subjects with factors that could cause significant changes in IOP and affect the accuracy of IOP measurement, and those who were unable to receive IOP measurement were excluded.Subjects were grouped according to sex, age and ethnicity, and the distribution and RI of IOP were compared among all groups.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Beijing Tongren Hospital, Capital Medical University (No.TRECKY2017-024). Written informed consent was obtained from each subject.

ResultsA total of 6 120 subjects (6 120 eyes) aged 18-90 years old were enrolled, including 2 850 males and 3 270 females with average age of (45.54±13.85) years.The average IOP of high-altitude population in Xining, Qinghai Province was (14.32±1.93) mmHg (1 mmHg=0.133 kPa), with the RI of 10.54-18.10 mmHg.The average IOP was (14.42±1.98) mmHg in male with the RI of 10.54-18.30 mmHg, (14.23±1.88) mmHg in female with the RI of 10.55-17.91 mmHg.The IOP of male was higher than that of female (t=3.71, P<0.001). The IOP of Han, Tibetan, Hui and other nationalities were (14.38±1.91), (13.93±2.06), (14.21±1.87), (13.94±1.95) mmHg, respectively, with a statistically significant overall difference (F=6.73, P<0.001). The IOP of Han nationality was significantly higher than that of Tibetan, Hui and other nationalities, and the differences were statistically significant (all atP<0.05).

ConclusionsRI of IOP in high-altitude population from Xining, Qinghai is lower compared with normal altitude area.

Intraocular pressure;Reference interval;Population, high-altitude;Central corneal thickness
Wang Ningli, Email: mocdef.3ab61.pivilgninw
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引用本文

杨一佺,包云兰,孙云晓,等. 青海西宁高原眼健康筛查人群眼压分布及参考区间[J]. 中华实验眼科杂志,2023,41(02)：166-172.

DOI:10.3760/cma.j.cn115989-20221004-00467

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眼压，即眼球内容物对眼球壁的压力，对维持正常眼结构和视觉功能至关重要，直接或间接地参与眼部生理和病理过程[ 1 ]。由于不同人的视神经对眼压的耐受程度不尽相同，眼压的个体差异性也较大，因此不能以某一数值而是用某一参考区间来定义正常眼压。参考区间又称参考范围、正常范围等，是用来表示健康人群人体结构、脏器功能和代谢水平的解剖、生理、生物化学指标的总体均数区间估计[ 2 ]，因种族、性别、年龄、生长发育等因素有所不同，还受所处区域、经济水平、生活习惯、饮食结构等多因素影响[ 3 ]。我国是高原人口大国，有超过6 000万人长期生活在不同海拔的高原和高山上，高原人口居世界首位[ 4 ]。但是目前尚缺乏对高原人群眼压分布及参考区间的报道。我国青海省西宁市海拔高度为2.271 km，可反映我国高原地区的人群分布特征。本研究对青海省西宁市开展以眼健康筛查人群为基础的眼病调查，确定高原人群眼压分布特征及参考区间。
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备注信息
A
王宁利，Email：mocdef.3ab61.pivilgninw
B

杨一佺：参与研究设计、文章起草、文章审核及修改；包云兰、孙云晓、谢媛、汪夏玲、刘优、谢延玲：参与实施研究；郝洁：审核文章内容的准确性；彭晓霞：数据统计分析及解释；范肃洁、吴世政：参与研究设计；王宁利：参与研究选题及设计，审核文章内容的准确性、可靠性及完整性并对研究中的所有环节进行把关

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北京同仁医院青年人才培养计划项目 (2020-YJJ-ZZL-023)
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