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ENGLISH ABSTRACT
P2X7受体及NLRP3炎性小体在炎症性疾病中的研究进展
唐园园
贺樟平
吴移谋
作者及单位信息
·
DOI： 10.3760/cma.j.cn112309-20221017-00340
Roles of P2X7 receptor and NLRP3 inflammasome in inflammatory diseases
Tang Yuanyuan
He Zhangping
Wu Yimou
Authors Info & Affiliations
Tang Yuanyuan
Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang 421001, China
He Zhangping
Department of Clinical Laboratory, Affiliated Nanhua Hospital of University of South China, Hengyang 421002, China
Wu Yimou
Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang 421001, China
·
DOI： 10.3760/cma.j.cn112309-20221017-00340
2011
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摘要

嘌呤能2X7受体(purinergic 2X7 receptor, P2X7R)是一种离子通道型受体，可引起核苷酸结合寡聚化结构域样受体3(nucleotide-binding oligomerization domain-like receptor protein 3, NLRP3)的激活，进而影响炎症细胞因子如IL-1β、IL-18等的释放从而参与多种炎症性疾病。近年来，P2X7R/NLRP3信号通路已成为炎症性疾病研究较多的通路之一，已有部分P2X7R和NLRP3炎性小体的拮抗剂进入早期的临床治疗。本文就P2X7R和NLRP3炎性小体的相关进展进行综述，为进一步验证P2X7R/NLRP3的激活导致IL-1β等炎症细胞因子在肿瘤和炎症性疾病中释放增加提供参考，为研究P2X7R/NLRP3作为肿瘤和炎症性疾病的重要病理机制和潜在的治疗靶点提供新的思路。

P2X7受体;NLRP3炎性小体;炎症性疾病;肿瘤;抑制剂
ABSTRACT

Purinergic 2X7 receptor (P2X7R) is an ionotropic receptor that is involved in various inflammatory diseases through affecting the release of inflammatory cytokines such as IL-1β and IL-18 after inducing the activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3). In recent years, the P2X7R/NLRP3 signaling pathway has become one of the more studied pathways in inflammatory diseases, and some inhibitors of P2X7R and NLRP3 have already been used in early clinical treatment. In this paper, the progress in P2X7R and NLRP3 was summarized, aiming to provide reference for further investigation on the roles of P2X7R/NLRP3 in the pathogenesis of tumors and inflammatory diseases and the potential of P2X7R/NLRP3 as therapeutic targets.

P2X7 receptor;NLRP3;Inflammatory diseases;Tumor;Inhibitor
Wu Yimou, Email: mocdef.aabnisuwuomiy, Tel: 0086-734-8282913
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引用本文

唐园园,贺樟平,吴移谋. P2X7受体及NLRP3炎性小体在炎症性疾病中的研究进展[J]. 中华微生物学和免疫学杂志,2023,43(04)：316-321.

DOI:10.3760/cma.j.cn112309-20221017-00340

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炎性复合体(inflammasome)也称炎性小体，是固有免疫应答的重要组成部分，为多种蛋白质组成的多蛋白复合体，其相对分子质量约为700×10 3，广泛存在于细胞内。嘌呤能受体主要分为3个家族：由腺苷激活的代谢性P1受体、由核苷酸激活的P2Y代谢性受体和由细胞外三磷酸腺苷(ATP)激活的P2X离子亲和性受体 [ 1 ]。P2X受体主要包括7个亚型(P2X1~7)，其中P2X7受体(P2X7 receptor, P2X7R)是一种离子通道型受体，由于其在炎症信号中的众多作用而被广泛研究。ATP作用于P2X7R后，活化核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎性小体，促进caspase-1的激活，活化后的caspase-1可促进IL-1β和IL-18的分泌，进而激活下游相关信号通路，与病原体感染、炎性疾病和肿瘤密切相关，提示P2X7R和NLRP3炎性小体可作为疾病预防及防治的分子靶点。本文对P2X7R及NLRP3炎性小体在肿瘤及炎性疾病中的作用进行综述。
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备注信息
A
吴移谋，Email： mocdef.aabnisuwuomiy，电话：0734-8282913
B
所有作者声明无利益冲突
C
国家自然科学基金 (31872643)
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