目的调查四川甘孜藏区50岁及以上人群白内障患病率、手术覆盖率及术后效果等,评价该地区防盲治盲效果。
方法采用横断面调查研究方法,在2017年10月至2018年4月使用可避免盲的快速评估方法(RAAB)对四川省甘孜州50岁及以上人群进行研究。参照甘孜州2010年全国第6次人口普查数据,使用RAAB软件,采用分层、整群随机抽样方法抽取50岁及以上常住居民共5 000人,每个人群组为50人,共100个人群组。由2个调查小组进行调查,对所有受检者入户进行视力和眼部检查,调查白内障患病率、手术覆盖率、手术障碍和术后效果。
结果5 000人中,接受检查的总人数为4 763人,受检率为95.3%。根据针孔矫正视力和2009年WHO视力损伤标准计算,甘孜州50岁及以上人群中双眼白内障致盲以及重度、中度和轻度视力损伤的患病率分别为0.6%(95% CI:0.4%~0.9%)、0.9%(95% CI:0.6%~1.2%)、2.4%(95% CI:2.0%~2.9%)、5.2%(95% CI:4.6%~5.9%);女性的白内障致盲患病率为0.7%(95% CI:0.4%~1.0%),显著高于男性的0.2%(95% CI:0.1%~0.5%),差异有统计学意义(P<0.05)。藏族人群的白内障致盲患病率为2.3%,高于汉族人群的1.0%,差异有统计学意义(P<0.05)。以眼数来统计,女性白内障手术覆盖率为60.8%(95%CI:55.5%~65.8%),低于男性的70.1%(95% CI:63.7%~75.7%),差异有统计学意义(P<0.05)。按人数来统计,以优势眼(双眼中视力较好眼)针孔矫正视力<0.05为盲的标准,双眼白内障致盲的白内障手术覆盖率为82.0%(95%CI:75.2%~87.6%)。共计171人未治疗白内障,并接受了白内障手术障碍问卷调查,结果显示最主要的障碍为"不知道可以接受治疗",占77.8%;其次为交通不便或无人陪同到医院,占11.7%。共计364眼接受过白内障手术,其中336眼植入人工晶状体,人工晶状体植入率为92.3%,216眼白内障术后视力≥0.3,占59.3%。
结论白内障仍是甘孜州50岁及以上人群盲的主要原因,手术治疗白内障依然是甘孜州防盲工作的重点。甘孜州白内障手术覆盖率较高,但白内障手术效果与WHO白内障手术后视力参考指标(1998)相比尚欠佳,须采取相应措施提高手术质量。
ObjectiveTo investigate the prevalence of cataract, cataract surgical coverage and surgical outcomes in people aged 50 years and older in Kandze Tibetan areas of Sichuan Province, and to evaluate the effectiveness of the prevention and treatment of blindness in the region.
MethodsA cross-sectional study was conducted to study the population aged 50 years and above in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, from October 2017 to April 2018 using the Rapid Assessment of Avoidable Blindness (RAAB) method.A total of 5 000 permanent residents aged 50 years and older were selected using a stratified, cluster sampling method with reference to the data from the 2010 China Population Census with the RAAB software, and each cluster consisted of 50 people, for a total of 100 clusters.The survey was conducted by two survey teams, and all subjects underwent visual acuity and ophthalmic examinations at home to investigate relevant cataract prevalence, surgical coverage, surgical barriers, and postoperative outcomes according to WHO Standards.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Kandze Prefecture People's Hospital (No.GZZYY-2016-11). Written informed consent was obtained from each subject.
ResultsOf 5 000 eligible participants, 4 763 were examined, with a response rate of 95.3%.Referred to the visual impairment standard of WHO and the pinhole visual acuity, the prevalence of bilateral blindness, severe, moderate and mild visual impairment was 0.6%(95% [confidence interval, CI]: 0.4%-0.9%), 0.9%(95%CI: 0.6%-1.2%), 2.4%(95% CI: 2.0%-2.9%) and 5.2%(95% CI: 4.6%-5.9%), respectively.The prevalence of cataract blindness was 0.7%(95% CI: 0.4%-1.0%) in females, significantly higher than 0.2%(95% CI: 0.1%-0.5%) in males(P<0.05). The prevalence of cataract blindness was 2.3% among Tibetan, higher than 1.0% among Han Chinese, showing a statistically significant difference (P<0.05). By the number of eyes, the cataract surgical coverage was 60.8%(95%CI: 55.5%-65.8%) in females, which was lower than 70.1%(95% CI: 63.7%-75.7%) in males, with a statistically significant difference (P<0.05). By the number of cases, the surgical coverage for cataract blindness in both eyes was 82.0%(95%CI: 75.2%-87.6%), with blindness defined as the pinhole visual acuity <0.05 in the dominant eye.A total of 171 people with untreated cataract received a questionnaire about barriers to cataract surgery.The most important barrier was unaware that treatment was available at 77.8%, followed by inconvenient transportation or being unaccompanied to the hospital at 11.7%.A total of 364 eyes underwent cataract surgery, of which 336 eyes underwent intraocular lens implantation, and the intraocular lens implantation rate was 92.3%.There were 216 eyes with a postoperative cataract visual acuity ≥0.3, accounting for 59.3%(216/364).
ConclusionsIn the Kandze Tibetan area of Sichuan Province, cataract is still the main cause of blindness among people aged 50 and above, and surgery for cataract remains the focus of blindness prevention work.The cataract surgical coverage in this area is high, but the postoperative outcomes are still poor compared with the WHO reference index for post-cataract surgery (1998), and corresponding measures must be taken to improve the quality of surgery.
嘉初丹巴,央京,蒋凤,等. 四川甘孜藏区50岁及以上人群白内障患病率及手术治疗情况调查[J]. 中华实验眼科杂志,2023,41(06):582-591.
DOI:10.3760/cma.j.cn115989-20210803-00444版权归中华医学会所有。
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嘉初丹巴:参与选题、研究实施、数据收集和分析、论文撰写和修改、最终定稿;央京:指导研究、审阅文章;蒋凤:参与研究实施、采集/整理数据;罗莉:参与研究实施、数据收集

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