调查研究
ENGLISH ABSTRACT
四川甘孜藏区50岁及以上人群白内障患病率及手术治疗情况调查
嘉初丹巴
央京
蒋凤
罗莉
作者及单位信息
·
DOI: 10.3760/cma.j.cn115989-20210803-00444
Prevalence and surgical status of cataract in adults aged 50 years and older in Kandze Tibetan areas of Sichuan, China
Jiachudanba
Yang jing
Jiang Feng
Luo Li
Authors Info & Affiliations
Jiachudanba
Kham Eye Centre, Kandze Prefecture People's Hospital, Ganzi Hospital, West China Hospital of Sichuan University, Kangding 626000, China
Yang jing
Kham Eye Centre, Kandze Prefecture People's Hospital, Ganzi Hospital, West China Hospital of Sichuan University, Kangding 626000, China
Jiang Feng
Kham Eye Centre, Kandze Prefecture People's Hospital, Ganzi Hospital, West China Hospital of Sichuan University, Kangding 626000, China
Luo Li
Kham Eye Centre, Kandze Prefecture People's Hospital, Ganzi Hospital, West China Hospital of Sichuan University, Kangding 626000, China
·
DOI: 10.3760/cma.j.cn115989-20210803-00444
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摘要

目的调查四川甘孜藏区50岁及以上人群白内障患病率、手术覆盖率及术后效果等,评价该地区防盲治盲效果。

方法采用横断面调查研究方法,在2017年10月至2018年4月使用可避免盲的快速评估方法(RAAB)对四川省甘孜州50岁及以上人群进行研究。参照甘孜州2010年全国第6次人口普查数据,使用RAAB软件,采用分层、整群随机抽样方法抽取50岁及以上常住居民共5 000人,每个人群组为50人,共100个人群组。由2个调查小组进行调查,对所有受检者入户进行视力和眼部检查,调查白内障患病率、手术覆盖率、手术障碍和术后效果。

结果5 000人中,接受检查的总人数为4 763人,受检率为95.3%。根据针孔矫正视力和2009年WHO视力损伤标准计算,甘孜州50岁及以上人群中双眼白内障致盲以及重度、中度和轻度视力损伤的患病率分别为0.6%(95% CI:0.4%~0.9%)、0.9%(95% CI:0.6%~1.2%)、2.4%(95% CI:2.0%~2.9%)、5.2%(95% CI:4.6%~5.9%);女性的白内障致盲患病率为0.7%(95% CI:0.4%~1.0%),显著高于男性的0.2%(95% CI:0.1%~0.5%),差异有统计学意义(P<0.05)。藏族人群的白内障致盲患病率为2.3%,高于汉族人群的1.0%,差异有统计学意义(P<0.05)。以眼数来统计,女性白内障手术覆盖率为60.8%(95%CI:55.5%~65.8%),低于男性的70.1%(95% CI:63.7%~75.7%),差异有统计学意义(P<0.05)。按人数来统计,以优势眼(双眼中视力较好眼)针孔矫正视力<0.05为盲的标准,双眼白内障致盲的白内障手术覆盖率为82.0%(95%CI:75.2%~87.6%)。共计171人未治疗白内障,并接受了白内障手术障碍问卷调查,结果显示最主要的障碍为"不知道可以接受治疗",占77.8%;其次为交通不便或无人陪同到医院,占11.7%。共计364眼接受过白内障手术,其中336眼植入人工晶状体,人工晶状体植入率为92.3%,216眼白内障术后视力≥0.3,占59.3%。

结论白内障仍是甘孜州50岁及以上人群盲的主要原因,手术治疗白内障依然是甘孜州防盲工作的重点。甘孜州白内障手术覆盖率较高,但白内障手术效果与WHO白内障手术后视力参考指标(1998)相比尚欠佳,须采取相应措施提高手术质量。

白内障;患病率;手术;健康调查;可避免盲的快速调查;甘孜藏区;中国
ABSTRACT

ObjectiveTo investigate the prevalence of cataract, cataract surgical coverage and surgical outcomes in people aged 50 years and older in Kandze Tibetan areas of Sichuan Province, and to evaluate the effectiveness of the prevention and treatment of blindness in the region.

MethodsA cross-sectional study was conducted to study the population aged 50 years and above in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, from October 2017 to April 2018 using the Rapid Assessment of Avoidable Blindness (RAAB) method.A total of 5 000 permanent residents aged 50 years and older were selected using a stratified, cluster sampling method with reference to the data from the 2010 China Population Census with the RAAB software, and each cluster consisted of 50 people, for a total of 100 clusters.The survey was conducted by two survey teams, and all subjects underwent visual acuity and ophthalmic examinations at home to investigate relevant cataract prevalence, surgical coverage, surgical barriers, and postoperative outcomes according to WHO Standards.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Kandze Prefecture People's Hospital (No.GZZYY-2016-11). Written informed consent was obtained from each subject.

ResultsOf 5 000 eligible participants, 4 763 were examined, with a response rate of 95.3%.Referred to the visual impairment standard of WHO and the pinhole visual acuity, the prevalence of bilateral blindness, severe, moderate and mild visual impairment was 0.6%(95% [confidence interval, CI]: 0.4%-0.9%), 0.9%(95%CI: 0.6%-1.2%), 2.4%(95% CI: 2.0%-2.9%) and 5.2%(95% CI: 4.6%-5.9%), respectively.The prevalence of cataract blindness was 0.7%(95% CI: 0.4%-1.0%) in females, significantly higher than 0.2%(95% CI: 0.1%-0.5%) in males(P<0.05). The prevalence of cataract blindness was 2.3% among Tibetan, higher than 1.0% among Han Chinese, showing a statistically significant difference (P<0.05). By the number of eyes, the cataract surgical coverage was 60.8%(95%CI: 55.5%-65.8%) in females, which was lower than 70.1%(95% CI: 63.7%-75.7%) in males, with a statistically significant difference (P<0.05). By the number of cases, the surgical coverage for cataract blindness in both eyes was 82.0%(95%CI: 75.2%-87.6%), with blindness defined as the pinhole visual acuity <0.05 in the dominant eye.A total of 171 people with untreated cataract received a questionnaire about barriers to cataract surgery.The most important barrier was unaware that treatment was available at 77.8%, followed by inconvenient transportation or being unaccompanied to the hospital at 11.7%.A total of 364 eyes underwent cataract surgery, of which 336 eyes underwent intraocular lens implantation, and the intraocular lens implantation rate was 92.3%.There were 216 eyes with a postoperative cataract visual acuity ≥0.3, accounting for 59.3%(216/364).

ConclusionsIn the Kandze Tibetan area of Sichuan Province, cataract is still the main cause of blindness among people aged 50 and above, and surgery for cataract remains the focus of blindness prevention work.The cataract surgical coverage in this area is high, but the postoperative outcomes are still poor compared with the WHO reference index for post-cataract surgery (1998), and corresponding measures must be taken to improve the quality of surgery.

Cataract;Prevalence;Surgery;Health survey;Rapid Assessment of Avoidable Blindness;Kandze Tibetan areas;China
Jiachudanba, Email: mocdef.qabq3958699931
引用本文

嘉初丹巴,央京,蒋凤,等. 四川甘孜藏区50岁及以上人群白内障患病率及手术治疗情况调查[J]. 中华实验眼科杂志,2023,41(06):582-591.

DOI:10.3760/cma.j.cn115989-20210803-00444

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据WHO资料显示,全世界有2.53亿人患有中重度视力损伤和盲,其中80%是可以避免的[ 1 ]。1999年全球发动"视觉2020计划",为消除可避免盲提出了倡议和指导。据《全球疾病负担研究》估计,从1990年至2010年,全球范围内白内障致盲和中重度视力损伤患病率分别从38.6%和25.6%降至33.4%和18.4%。但是白内障仍是我国乃至全世界50岁及以上人群中主要的致盲原因[ 2 ]。甘孜藏族自治州位于四川省西部、青藏高原东南,面积15万平方公里,总人口109万,是一个以藏族为主体民族的地级行政区(78%为藏族),约87.1%的人口生活在地域广阔的农牧区,其中农区是以农业生产为主的地区;牧区则是以畜牧业生产为主的地区,人们为牛寻找牧场来源定期迁徙;居民主要集中居住在州府康定市和各县县城。位于甘孜州首府康定的甘孜州人民医院康巴眼科中心是该地区唯一提供眼科服务的眼科机构,不同于中国许多其他地区的眼科,结合高原眼科高发疾病情况,通过巡回免费筛查、巡回免费手术和免费接送患者到医院等方式,长期致力于甘孜州乃至整个康巴高原地区的防盲治盲工作,每年约完成3 000例白内障手术,其中超过50%为免费手术,这使得甘孜州的白内障手术率为0.3%,几乎与中国一些发达地区相同。但甘孜州缺少对既往防盲治盲工作的回顾性研究总结,为更好地了解甘孜州白内障的患病状况及评价多年来以白内障手术治疗为主的防盲治盲工作的效果,本研究团队于2017年10月至2018年4月在甘孜州开展可避免盲的快速调查(Rapid Assessment of Avoidable Blindness,RAAB)[ 3 ],以及白内障患病和手术服务利用情况等数据,以期为甘孜州的防盲治盲工作提供新的流行病学数据,同时为政府部门制订防盲治盲政策提供科学依据。通过RAAB调查,能够在人群中快速筛查盲和视力损伤的患病率和致病原因,以及白内障患病和手术状况等数据[ 4 ]。本研究调查四川甘孜藏区50岁及以上人群白内障患病率和手术状况,并评估影响当地眼健康服务情况的影响因素。
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备注信息
A
嘉初丹巴,Email:mocdef.qabq3958699931
B

嘉初丹巴:参与选题、研究实施、数据收集和分析、论文撰写和修改、最终定稿;央京:指导研究、审阅文章;蒋凤:参与研究实施、采集/整理数据;罗莉:参与研究实施、数据收集

C
所有作者均声明不存在利益冲突
D
四川省科技厅科学研究基金项目 (2020YFS0537)
四川省卫生厅科学研究基金项目 (080132)
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