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ENGLISH ABSTRACT
HIF-1α调控的巨噬细胞极化在免疫相关疾病中作用的研究进展
唐梦燕
闫东梅
作者及单位信息
·
DOI： 10.3760/cma.j.issn.1673-4394.2023.05.009
Research progress on the role of HIF-1α-regulated macrophage polarization in immune related disease
Tang Mengyan
Yan Dongmei
Authors Info & Affiliations
Tang Mengyan
Department of Immunology, School of Basic Medicine, Jilin University, Changchun 130021, China
Yan Dongmei
Department of Immunology, School of Basic Medicine, Jilin University, Changchun 130021, China
·
DOI： 10.3760/cma.j.issn.1673-4394.2023.05.009
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摘要

缺氧诱导因子1α(hypoxia-inducible factor-1α，HIF-1α)在巨噬细胞极化的过程中必不可少，是将糖代谢活动与免疫联系起来的枢纽。文章就HIF-1α调控的巨噬细胞极化及其在细菌感染性疾病、肿瘤、自身免疫病和动脉粥样硬化等疾病中作用进行综述，期望以HIF-1α调控的巨噬细胞极化为主要靶标，为疾病的发生机制及临床治疗提供新的思路。

缺氧诱导因子1α;巨噬细胞;极化;免疫相关疾病
ABSTRACT

Hypoxia-inducible factor-1α(HIF-1α) is essential in the process of macrophage polarization, serving as a hub linking glucose metabolic activity to immunity. This review summarizes the research progress of HIF-1α-regulated macrophage polarization and its role in tumors, autoimmune diseases, atherosclerosis and other diseases. It is expected that HIF-1α-regulated macrophage polarization will be the main target, and provide new ideas for the mechanism and clinical treatment of diseases.

Hypoxia-inducible factor-1α;Macrophages;Polarization;Immune related disease
YanDongmei, Email: nc.defudabe.uljnaymd, Tel: 0431-85619476
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引用本文

唐梦燕,闫东梅. HIF-1α调控的巨噬细胞极化在免疫相关疾病中作用的研究进展[J]. 国际免疫学杂志,2023,46(05)：524-528.

DOI:10.3760/cma.j.issn.1673-4394.2023.05.009

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缺氧诱导因子1α(hypoxia-inducible factor-1α，HIF-1α)作为重要的转录因子，不仅可以调节糖酵解过程中的限速酶，如乳酸脱氢酶和丙酮酸脱氢酶激酶等[ 1 , 2 ]，还可以调节免疫炎症基因如白细胞介素(interleukin, IL)-1β、IL-8、肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)和诱导型一氧化氮合酶(inducible nitric oxide synthase，iNOS)，从而调节细胞的增殖、凋亡和分化等[ 3 ]。HIF-1α在极化的巨噬细胞参与感染性疾病、肿瘤、自身免疫病和动脉粥样硬化等疾病的进程中发挥着重要的调节作用。
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备注信息
A
闫东梅，Email：nc.defudabe.uljnaymd，电话：0431-85619476
B
所有作者均声明不存在利益冲突
C
国家自然科学基金 (81871245)
吉林省科技厅项目 (20210509009RQ)
吉林省教育厅项目 (JJKH20221057KJ)
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