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光学相干弹性成像在眼科学领域的应用研究进展
赵雁之
黄国富 [综述]
作者及单位信息
·
DOI： 10.3760/cma.j.cn115989-20221116-00533
Advances in optical coherence elastography in ophthalmology
Zhao Yanzhi
Huang Guofu
Authors Info & Affiliations
Zhao Yanzhi
Ophthalmology Center, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China
Huang Guofu
Ophthalmology Center, The Third Affiliated Hospital of Nanchang University, Nanchang 330000, China
Huang Guofu is working at Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China
·
DOI： 10.3760/cma.j.cn115989-20221116-00533
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摘要

光学相干弹性成像(OCE)是近年发展起来用于获取组织生物力学性能的新兴技术，类似于光学相干断层扫描血管成像，是一种功能性光学相干断层扫描成像技术。OCE技术通过探测眼球各组织在载荷激励下的力学响应，定量分析组织的应力－应变曲线或杨氏模量等生物力学指标，从而绘制出其弹性二维/三维图像。OCE具有多种优势，包括非侵入性、高分辨率、实时快速和三维成像能力；此外，该技术实现了结构图像和弹性图像相融合，能够同时提供眼组织的结构和力学属性信息，为眼科疾病的诊断和发病机制研究提供了新的视角和维度。本文从OCE的成像原理出发，就OCE的技术分类和研究现状，其在眼科领域的研究进展，包括辅助角膜屈光手术设计、圆锥角膜患者筛查、角膜交联手术疗效评估、白内障诊断分级、视网膜生物力学测量和近视发病机制研究等，以及OCE在实现眼科临床转化中面临的挑战和机遇进行综述。

光学相干断层扫描成像;光学相干弹性成像;生物力学性质;诊断技术;眼科
ABSTRACT

Optical coherence elastography (OCE) is a novel technique developed in recent years to investigate the biomechanical properties of tissues, similar to optical coherence tomography angiography, a functional version of optical coherence tomography.OCE utilizes load excitation to detect the mechanical response of ocular tissues, facilitating quantitative analysis of stress-strain curves, Young's modulus, and other biomechanical indicators.It also generates two-dimensional/three-dimensional elastic maps of the tissues.With its noninvasive, high-resolution, real-time, rapid, and three-dimensional imaging capabilities, OCE provides both structural and mechanical information about ocular tissues, opening up new dimensions in ocular disease diagnosis and pathogenesis research.This article introduced the technical classification and research status of OCE, and highlighted its research progress in ophthalmology, including its applications in assisted refractive surgery design, keratoconus patient screening, assessment of corneal cross-linking surgery efficacy, cataract diagnosis and grading, measurement of retinal biomechanics, and research into myopia pathogenesis.The challenges and opportunities for clinical translation of OCE in ophthalmology were also discussed.

Optical coherence tomography;Optical coherence elastography;Biomechanics;Diagnostic techniques;Ophthalmology
Huang Guofu, Email: mocdef.aabnis2222fgh
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引用本文

赵雁之,黄国富. 光学相干弹性成像在眼科学领域的应用研究进展[J]. 中华实验眼科杂志,2023,41(10)：1043-1048.

DOI:10.3760/cma.j.cn115989-20221116-00533

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人体组织病理性改变通常会伴随力学特征，如硬度、弹性、黏弹性等的变化，弹性成像技术通过测量组织或器官在载荷激励下的形变来获得该组织器官的生物力学信息，从而提供有价值的临床诊断信息。光学相干弹性成像(optical coherence elastography，OCE)是一种基于宽带光谱的干涉原理获取组织生物力学性质的新兴技术。OCE是光学相干断层扫描(optical coherence tomography，OCT)技术的延伸，类似于光学相干断层扫描血管成像，是一种功能性OCT，可以同时提供组织的结构和生物力学性质信息。OCE不仅保持了OCT的无创、非侵入、高分辨率、实时快速三维成像的优势，而且可以实现生物组织的高精度弹性定量检测。1998年Schmitt[ 1 ]首次提出，OCE技术已被用于多个学科的疾病诊断和治疗监测，包括眼科学、肿瘤学、皮肤病学和心脏病学等[ 2 , 3 , 4 , 5 ]，特别是在眼组织生物力学性质检测方面表现出了巨大的应用潜能。目前OCE技术在角膜、晶状体、视网膜等组织弹性成像方面的可行性及准确性已得到了充分验证[ 6 , 7 ]。本文将从OCE成像原理出发，介绍OCE检测眼组织生物力学性质的相关研究及进展，并探讨当前OCE技术在眼科临床转化应用中面临的挑战和未来发展方向。
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黄国富，Email：mocdef.aabnis2222fgh
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国家自然科学基金项目 (82360215)
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