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ENGLISH ABSTRACT
长沙市1例人感染H3N8禽流感病例的流行病学调查和病原学分析
赵锦
杨学文
刘如春
周银柱
陈水连
邱劲松
黄政
作者及单位信息
·
DOI： 10.3760/cma.j.cn112338-20230524-00329
Epidemiological investigation and etiological analysis on a case of human infection with avian influenza A (H3N8) virus in Changsha
Zhao Jin
Yang Xuewen
Liu Ruchun
Zhou Yinzhu
Chen Shuilian
Qiu Jinsong
Huang Zheng
Authors Info & Affiliations
Zhao Jin
Changsha Municipal Center for Disease Control and Prevention, Changsha 410000, China
Yang Xuewen
Changsha Municipal Center for Disease Control and Prevention, Changsha 410000, China
Liu Ruchun
Changsha Municipal Center for Disease Control and Prevention, Changsha 410000, China
Zhou Yinzhu
Changsha Municipal Center for Disease Control and Prevention, Changsha 410000, China
Chen Shuilian
Changsha Municipal Center for Disease Control and Prevention, Changsha 410000, China
Qiu Jinsong
Changsha Municipal Center for Disease Control and Prevention, Changsha 410000, China
Huang Zheng
Changsha Municipal Center for Disease Control and Prevention, Changsha 410000, China
·
DOI： 10.3760/cma.j.cn112338-20230524-00329
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摘要

目的了解人感染H3N8禽流感病例的流行病学特征和临床特征及其病原的分子生物学特征，为人感染H3N8禽流感防控提供科学依据。

方法采用流行病学调查方法对长沙市2022年5月1例人感染H3N8禽流感病例的可疑暴露史、感染途径、发病及就诊经过，以及密切接触者、可疑暴露者等涉疫重点人员进行现场调查，并进行描述性分析；采用核酸检测和基因测序技术，进行病原学检测和基因特征分析。

结果病例发病前6 d有活禽交易市场暴露史，在活禽交易市场、活禽来源批发市场均检测出禽流感H3、N8亚型阳性。深度基因测序显示，病毒对哺乳动物发生适应性突变，对烷胺类药物敏感性降低，未检测到神经氨酸酶抑制剂类药物和聚合酶抑制剂类药物相关的耐药性突变。

结论病例暴露于被H3N8禽流感病毒污染的活禽交易市场环境而感染，未发现人际间传播。

流行病学;病原学;人感染H3N8禽流感病毒
ABSTRACT

ObjectiveTo understand the epidemiological and clinical characteristics of human infection with avian influenza A(H3N8) virus and the molecular biological characteristics of the pathogen, and provide scientific evidence for the prevention and control of human infection with avian influenza A(H3N8) virus.

MethodsAn epidemiological investigation was conducted for a case of human infection with avian influenza A(H3N8) virus in Changsha in May 2022 to collect the information about exposure history, route of infection, onset and treatment, potential contacts and other possible exposures for a descriptive analysis. Nucleic acid detection and gene sequencing were used to detect the pathogen and analyze the genetic characteristics.

ResultsThe case had a history of exposure to live poultry trading market 6 days before the onset of illness. Subtypes H3 and N8 of avian influenza virus were detected in live poultry markets. Deep gene sequencing showed that the virus had adaptive mutations in mammals, reduced sensitivity to alkamine agent, and no resistance mutations related to neuraminidase inhibitors and polymerase inhibitors were detected.

ConclusionThe case was infected due to exposure to the live poultry market environment contaminated by avian influenza A(H3N8) virus, and no human to human transmission was found.

Epidemiology;Etiology;Human infection of avian influenza A(H3N8) virus
Yang Xuewen, Email: mocdef.qabq946157477
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引用本文

赵锦,杨学文,刘如春,等. 长沙市1例人感染H3N8禽流感病例的流行病学调查和病原学分析[J]. 中华流行病学杂志,2023,44(11)：1776-1780.

DOI:10.3760/cma.j.cn112338-20230524-00329

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H3N8禽流感病毒宿主范围广，除感染禽类外，还可感染马、犬、骆驼等哺乳动物，且跨越物种屏障传播广泛存在 ［ 1 ］ 。2022年4月26日河南省驻马店市通报1例人感染H3N8禽流感病例，5月19日湖南省长沙市通报1例人感染H3N8禽流感病例。以上案例表明，H3N8禽流感病毒存在感染人类的风险。本研究对长沙市报告病例的流行病学特征、分子生物学特征和临床特征进行分析，探讨人感染H3N8禽流感发生和传播途径，为人感染H3N8禽流感防控提供科学依据。
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备注信息
A
杨学文，Email： mocdef.qabq946157477
B

赵锦、杨学文、刘如春：数据整理、论文撰写/修改；周银柱、陈水连、邱劲松、黄政：论文修改、文献查阅

C
赵锦, 杨学文, 刘如春, 等. 长沙市1例人感染H3N8禽流感病例的流行病学调查和病原学分析[J]. 中华流行病学杂志, 2023, 44(11): 1776-1780. DOI: 10.3760/cma.j.cn112338-20230524-00329.
D
Zhao J, Yang XW, Liu RC, et al. Epidemiological investigation and etiological analysis on a case of human infection with avian influenza A（H3N8）virus in Changsha[J]. Chin J Epidemiol, 2023, 44(11):1776-1780. DOI: 10.3760/cma.j.cn112338-20230524-00329.
E
所有作者声明无利益冲突
F
湖南省卫生健康委员会科研计划项目 (202212064383)
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