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ENGLISH ABSTRACT
卵巢衰老的机制与治疗策略
何甜甜
许博
杜星
付旭锋
作者及单位信息
·
DOI： 10.3760/cma.j.cn101441-20230413-00154
Mechanisms and treatment strategies of ovarian aging
He Tiantian
Xu Bo
Du Xing
Fu Xufeng
Authors Info & Affiliations
He Tiantian
Key Laboratory of Fertility Maintenance, Ministry of Education, Ningxia Medical University, Yinchuan 750000, China
Xu Bo
Key Laboratory of Fertility Maintenance, Ministry of Education, Ningxia Medical University, Yinchuan 750000, China
Du Xing
Key Laboratory of Fertility Maintenance, Ministry of Education, Ningxia Medical University, Yinchuan 750000, China
Fu Xufeng
Key Laboratory of Fertility Maintenance, Ministry of Education, Ningxia Medical University, Yinchuan 750000, China
·
DOI： 10.3760/cma.j.cn101441-20230413-00154
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摘要

卵巢作为女性的重要生殖器官在维持生殖健康和生活质量中具有重要作用。卵巢衰老是指卵巢功能下降直至最终衰竭的过程，不仅会导致女性生育能力的下降，而且还会加速女性衰老并引起一系列相关疾病，严重威胁女性生殖健康和生活质量。因此，阐明卵巢衰老的机制并进一步探究卵巢的抗衰老策略，对减缓卵巢衰老和保持女性生育力具有重要意义。本综述回顾分析了国内外卵巢衰老相关研究，总结了当前卵巢衰老的相关机制并提出了相应的预防和治疗策略。

卵巢颗粒细胞;卵巢衰老;抗衰老
ABSTRACT

As an important reproductive organ in women, ovary plays a vital role in maintaining reproductive health and quality of life. Ovarian aging refers to the decline of ovarian function and eventually failure, which not only leads to the decline of female fertility, but also accelerates female aging and causes a series of related diseases, which seriously threatens female reproductive health and quality of life. Therefore, elucidating the mechanism of ovarian aging and further exploring the anti-aging strategies of the ovary are of great significance for slowing down ovarian aging and maintaining female fertility. This article reviews and analyzes the relevant studies of ovarian aging at home and abroad, summarizes the relevant mechanisms of ovarian aging and puts forward the corresponding prevention and treatment strategies.

Ovarian granulosa cells;Ovarian aging;Anti-aging
Fu Xufeng, Email: mocdef.3ab61001gnefuxuf, Tel: +86-951-6980178
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引用本文

何甜甜,许博,杜星,等. 卵巢衰老的机制与治疗策略[J]. 中华生殖与避孕杂志,2024,44(07)：755-758.

DOI:10.3760/cma.j.cn101441-20230413-00154

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在现代社会，不孕症被视为威胁人类的三大疾病之一，发病率高达15%~20% ［ 1 ］ 。2017年的调查研究显示，中国有妊娠意愿女性的不孕症患病率为25.0%，其中约40%与卵巢衰老有关 ［ 2 ］ 。卵巢衰老是指卵巢功能逐渐下降并最终耗竭的过程，可分为生理性衰老和病理性衰老两大类。生理性卵巢衰老是指卵巢功能随年龄增长而自然退化直至绝经的过程。病理性卵巢衰老是指与年龄不符的卵巢功能过早下降，包括有早发性卵巢功能不全（premature ovarian insufficiency，POI）、卵巢早衰（premature ovarian failure，POF）、卵巢储备功能减退、卵巢低反应 ［ 3 ］ 。卵巢衰老的终末阶段是绝经期。绝经后，随着女性体内激素的变化，内分泌、心血管和神经系统等的功能障碍加剧。因此，卵巢衰老被认为是女性衰老过程中的一个重要节点。延缓和预防卵巢衰老已成为改善女性生活质量的迫切需求，通过挖掘卵巢衰老的机制并提出卵巢的抗衰老策略，对于女性健康以及社会发展有重要意义。
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备注信息
A
付旭锋，Email： mocdef.3ab61001gnefuxuf，电话：+86-951-6980178
B

何甜甜负责论文撰写、论文修改；许博负责论文撰写；杜星负责论文修改；付旭锋负责研究指导、论文修改和经费支持

C
何甜甜, 许博, 杜星, 等. 卵巢衰老的机制与治疗策略[J]. 中华生殖与避孕杂志, 2024, 44(7): 755-758. DOI: 10.3760/cma.j.cn101441-20230413-00154.
D
所有作者均声明不存在利益冲突
E
国家自然科学基金 (81960270)
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