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血管性痴呆
林爽
王传杰
吴毅
作者及单位信息
·
DOI： 10.3760/cma.j.issn.1673-4165.2023.07.008
Vascular dementia
Lin Shuang
Wang Chuanjie
Wu Yi
Authors Info & Affiliations
Lin Shuang
School of Sports and Health, Shanghai University of Sport, Shanghai 200438, China
Department of Rehabilitation Medicine, Huashan Hospital of Fudan University, Shanghai 200040, China
Wang Chuanjie
Department of Rehabilitation Medicine, Jinshan Hospital of Fudan University, Shanghai 200540, China
Wu Yi
School of Sports and Health, Shanghai University of Sport, Shanghai 200438, China
Department of Rehabilitation Medicine, Huashan Hospital of Fudan University, Shanghai 200040, China
·
DOI： 10.3760/cma.j.issn.1673-4165.2023.07.008
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摘要

血管性痴呆是一种严重的认知损害综合征，可严重影响患者正常生活。在人口老龄化日趋严重的背景下，血管性痴呆发病率居高不下。然而，血管性痴呆的发病机制目前尚未完全阐明，亦无特效治疗药物和标准治疗方法。因此，文章对血管性痴呆的危险因素、发病机制以及治疗进行了综述，以期为其治疗和康复提供借鉴和参考。

痴呆，血管性;认知障碍;脑血管障碍;危险因素
ABSTRACT

Vascular dementia is a severe cognitive impairment syndrome that can seriously affect the normal life of patients. In the context of the increasingly serious aging of the population, the incidence rate of vascular dementia remains high. However, the pathogenesis of vascular dementia has not yet been fully elucidated, and there are no specific therapeutic drugs or standard treatment methods available. Therefore, this article reviews the risk factors, pathogenesis, and treatment of vascular dementia, in order to provide reference for its treatment and rehabilitation.

Dementia, vascular;Cognition disorders;Cerebrovascular disorders;Risk factors
Wu Yi, Email: mocdef.3ab610004iyuw
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引用本文

林爽,王传杰,吴毅. 血管性痴呆[J]. 国际脑血管病杂志,2023,31(07)：529-534.

DOI:10.3760/cma.j.issn.1673-4165.2023.07.008

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血管性痴呆（vascular dementia, VaD）是一种由脑血管病引起的严重认知损害综合征。VaD患者可出现记忆力下降、思维迟钝、定向功能和执行功能障碍以及情绪和性格变化等临床表现 [ 1 ]，严重影响日常生活活动能力。在人口老龄化日趋严重的背景下，全球老年痴呆患者人数不断增加，VaD约占所有痴呆患者的20%，是仅次于阿尔茨海默病（Alzheimer's disease, AD）的第二大痴呆类型 [ 2 ]。在亚洲和发展中国家，VaD约占所有痴呆患者的30% [ 3 ]。中国作为全世界痴呆患者人数最多的国家，60岁及以上人群中VaD的年发病率为242/1 000人·年 [ 4 , 5 ]。然而，VaD的发病机制目前尚未完全阐明，亦无特效治疗药物和标准治疗方法 [ 6 ]。鉴于VaD导致患者生活质量持续且不可逆性恶化，给家庭和社会带来巨大医疗和经济负担 [ 6 ]。
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吴毅，Email： mocdef.3ab610004iyuw
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国家重点研发计划项目 (2018YFC2001700)
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