首页 中华实验眼科杂志 2024年42卷06期 XEN凝胶引流管植入术在青光眼治疗中的应用研究进展
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ENGLISH ABSTRACT
XEN凝胶引流管植入术在青光眼治疗中的应用研究进展
陈茵琪 
姚贻华
[综述]
[综述]
朱益华 
[综述]
[综述]
作者及单位信息
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DOI： 10.3760/cma.j.cn115989-20220406-00140
Research progress on the application of XEN gel stent implantation in glaucoma treatment
Chen Yinqi
Yao Yihua
Zhu Yihua
Authors Info & Affiliations
Chen Yinqi
Department of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, National Regional Medical Center, Binhai Campus of The First Affiliated Hospital, Fujian Medical University, Fujian Institute of Ophthalmology, Fujian Provincial Clinical Medical Research Center of Eye Diseases and Optometry, Fuzhou 350005, China
Yao Yihua
Department of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, National Regional Medical Center, Binhai Campus of The First Affiliated Hospital, Fujian Medical University, Fujian Institute of Ophthalmology, Fujian Provincial Clinical Medical Research Center of Eye Diseases and Optometry, Fuzhou 350005, China
Zhu Yihua
Department of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, National Regional Medical Center, Binhai Campus of The First Affiliated Hospital, Fujian Medical University, Fujian Institute of Ophthalmology, Fujian Provincial Clinical Medical Research Center of Eye Diseases and Optometry, Fuzhou 350005, China
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DOI： 10.3760/cma.j.cn115989-20220406-00140
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摘要
XEN凝胶引流管植入术是一种新型微创青光眼手术(MIGS)，通过一种新型交联材料制成的微型引流管构建房水流出的结膜下外引流新通路。引流管可应用内、外入路2种方法植入，二者各有优劣。目前，XEN凝胶引流管已在多种类型的青光眼及白内障超声乳化联合手术中证实了其长、短期良好的有效性及安全性，并与其他抗青光眼滤过性手术展开对比研究。术后滤过泡相关的并发症常见，针刺分离和开放性滤过泡修复常用于其术后干预。该术式是MIGS的典型代表，具有操作较简单、组织损伤小、手术时间短、降眼压效果良好、安全性好等优点，明显扩大了MIGS适应证的范围，在青光眼治疗中具有良好的临床应用前景。本文就XEN凝胶引流管的材料及其特性、手术操作技巧、适应证及禁忌证、临床应用、并发症等研究进展进行综述。
青光眼;青光眼引流植入物;眼科手术;临床进展
ABSTRACT
XEN gel stent implantation, a novel minimally invasive glaucoma surgery (MIGS), constructs a novel subconjunctival external filtration pathway for aqueous humor outflow through a microfilter tube made of an innovative cross-linked material.The implant can be inserted via ab interno and ab externo approaches, each with its advantages and disadvantages.At present, XEN gel stent has demonstrated satisfactory efficacy and safety in both the short and long term in various types of glaucoma and combined phacoemulsification.Comparative studies with other filtering glaucoma surgeries have been conducted.Postoperative bleb-related complications are the most common ones, which are often treated by needling and open bleb revision.This procedure is a typical representative of MIGS, which offers the advantages of easy operation, less invasive, shorter operation time, valid intraocular pressure reduction, fewer complications and high safety, therefore significantly expanding the range of indications for MIGS and offering a favorable application prospect for clinical treatment of glaucoma.This article reviews the research progress of the material and characteristics, surgical techniques, indications and contraindications, clinical applications and complications of XEN gel stent.
Glaucoma;Glaucoma drainage implants;Ophthalmologic surgical procedures;Clinical progress
Zhu Yihua, Email:
mocdef.3ab61902auhiyuhz
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引用本文
陈茵琪,姚贻华,朱益华. XEN凝胶引流管植入术在青光眼治疗中的应用研究进展[J]. 中华实验眼科杂志,2024,42(06)：547-556.
DOI:10.3760/cma.j.cn115989-20220406-00140PERMISSIONS
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青光眼是主要的不可逆性致盲眼病，主要特征为眼压病理性升高，从而导致进行性视神经损伤和视野缺损，降低眼压为其关键治疗手段。目前主要治疗术式仍为传统滤过性手术，以小梁切除术为代表。但该术式并发症较多，如术后浅前房、持续性低眼压、角膜失代偿、切口瘢痕化及眼内炎等
[
1
]。与传统滤过性术式相比，微创青光眼手术(minimally invasive glaucoma surgery，MIGS)操作较简单有效，其中，XEN凝胶引流管植入术因其手术创伤小、手术时间短、安全性和有效性高，近年来在临床上得到广泛应用。本文就XEN凝胶引流管植入术在青光眼治疗中的应用研究进展进行综述。
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备注信息
A
朱益华，Email：
mocdef.3ab61902auhiyuhz
B
所有作者均声明不存在利益冲突
C
国家自然科学基金 (81970789)
福建省自然科学基金 (2020J05251)
福建省科学技术厅科技创新联合资金项目 (2023Y9027)
福建省科技创新平台项目 (2021Y2004)
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