临床研究
ENGLISH ABSTRACT
应用非线性混合效应建模法评估 99Tc m-DMSA用于儿童肾静态显像的量-效关系
谢力斯
吴敏
王朝阳
方磊
刘涛
李梅
李环
王芳
汪洋
作者及单位信息
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DOI: 10.3760/cma.j.cn321828-20240124-00033
Nonlinear mixed-effects modeling method for evaluating dose-response relationship of 99Tc m-DMSA in pediatric renal static imaging
Xie Lisi
Wu Min
Wang Zhaoyang
Fang Lei
Liu Tao
Li Mei
Li Huan
Wang Fang
Wang Yang
Authors Info & Affiliations
Xie Lisi
Department of Nuclear Medicine, Wuhan Children′s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
Wu Min
Department of Nuclear Medicine, Wuhan Children′s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
Wang Zhaoyang
Department of Nuclear Medicine, Wuhan Children′s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
Fang Lei
Department of Nuclear Medicine, Wuhan Children′s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
Liu Tao
Department of Nuclear Medicine, Wuhan Children′s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
Li Mei
Department of Nuclear Medicine, Wuhan Children′s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
Li Huan
Department of Nuclear Medicine, Wuhan Children′s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
Wang Fang
Department of Nuclear Medicine, Wuhan Children′s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
Wang Yang
Office of Clinical Trial Institution, Wuhan Children′s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
·
DOI: 10.3760/cma.j.cn321828-20240124-00033
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摘要

目的分析 99Tc m-二巯基丁二酸(DMSA)用于儿童肾静态显像的剂量-效应(量-效)关系。

方法回顾性收集2022年1月至2023年11月间于华中科技大学同济医学院附属武汉儿童医院接受 99Tc m-DMSA肾静态显像患儿的资料(模型组199例,男81例、女118例;验证组30例,男13例、女17例;年龄均为1个月~14岁),记录每例患儿给药后双肾扫描放射计数及相关临床信息,采用视觉模拟评分(VAS)法对显像质量进行评价,采用ROC曲线分析探讨放射计数强度(RCI)与显像质量间的关系。采用非线性混合效应建模法建立 99Tc m-DMSA用于儿童肾静态显像的量-效关系模型,进行内外部验证,并基于最终模型,评价患儿的给药方案。

结果患儿体质量是影响 99Tc m-DMSA肾静态显像量-效关系的因素( χ 2值:120.79和116.36,均 P<0.05)。ROC曲线分析显示,当患儿肾前位RCI≥32.61(界值)、肾后位RCI≥35.46(界值)时图像质量满足诊断要求。内部和外部验证结果显示,建立的量-效模型预测性能较好。基于最终模型剂量折线图剂量给药,图像质量可以满足临床诊断要求。

结论成功建立 99Tc m-DMSA用于患儿肾静态显像的量-效关系模型,基于模型的患儿个体化给药剂量可为临床个体化给药剂量决策提供科学依据。

剂量效应关系,辐射;放射性核素显像;99m锝二巯基丁二酸;儿童
ABSTRACT

ObjectiveTo analyze the dose-response relationship of 99Tc m-dimercaptosuccinic acid (DMSA) in pediatric renal static imaging.

MethodsA retrospective analysis of children (model group: n=199, 81 males, 118 females; validation group: n=30, 13 males, 17 females; all age: 1 month-14 years) who underwent 99Tc m-DMSA renal static imaging from January 2022 to November 2023 in Wuhan Children′s Hospital, Tongji Medical College, Huazhong University of Science and Technology were conducted. Post-administration radiation counts and related clinical data were collected. Imaging quality was evaluated using visual analogue scoring (VAS). ROC curve analysis was used to assess the relationship between radiation count intensity (RCI) and imaging quality. A nonlinear mixed-effects modeling method was employed to establish the dose-response relationship for 99Tc m-DMSA in pediatric renal static imaging. Internal and external validations of the model were performed. Final model was utilized to evaluate patient dosing protocols.

ResultsBody weight was considered as a significant determinant of the dose-response relationship in 99Tc m-DMSA renal static imaging( χ 2 values: 120.79, 116.36, both P<0.05). ROC curve analysis showed that the quality of diagnostic images was acceptable when the anterior renal RCI was ≥32.61 (cut-point) and the posterior renal RCI was ≥35.46 (cut-point). Both internal and external validation results demonstrated that the dose-response model established exhibited good prediction performance. Based on the final model graph, the image quality could meet the requirements for clinical diagnosis.

ConclusionsThe 99Tc m-DMSA dose-response model for pediatric renal static imaging is successfully established. Individualized dosage based on the model can provide a reference for clinical individualized dosing decision-making.

Dose-response relationship, radiation;Radionuclide imaging;Technetium Tc 99m dimercaptosuccinic acid;Child
Wang Fang, Email: mocdef.eabfhwgzgnafgnaw;
Wang Yang, Email: mocdef.eabfhwgzgnaygnaw
引用本文

谢力斯,吴敏,王朝阳,等. 应用非线性混合效应建模法评估 99Tc m-DMSA用于儿童肾静态显像的量-效关系 [J]. 中华核医学与分子影像杂志,2024,44(12):724-729.

DOI:10.3760/cma.j.cn321828-20240124-00033

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99Tc m-二巯基丁二酸(dimercaptosuccinic acid, DMSA)肾静态显像是一种非侵入性、高精确度和高灵敏度的显像技术,可通过肾脏对显像剂的摄取率来反映肾脏的受损程度 [ 1 ],是评估发热性尿路感染及肾脏皮质受累情况的"金标准",在校正肾积水小儿患肾的肾脏深度及ROI方面有一定优势 [ 2 ]99Tc m-DMSA是用于儿童肾静态显像的重要显像剂。个体化用药是保证其安全合理使用的重要措施。然而,目前国内外关于 99Tc m-DMSA在患儿体内生物分布特征和剂量-效应(量-效)关系的研究报道较少,这限制了个体化给药的实施 [ 3 ]。临床尚无统一的患儿 99Tc m-DMSA给药剂量标准,因患儿个体差异造成的剂量不足,有时会影响阅片质量。因此,如何使用最低有效的放射性药物剂量以达到良好的显像质量是一个亟待解决的问题。为此,本研究尝试采用非线性混合效应建模法评估 99Tc m-DMSA用于患儿肾静态显像检查的量-效关系,并通过模拟试验推荐不同特征患儿的优化给药方案,为 99Tc m-DMSA在儿科临床的个体化用药提供参考。
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备注信息
A
王芳,Email: mocdef.eabfhwgzgnafgnaw
B
汪洋,Email: mocdef.eabfhwgzgnaygnaw
C

谢力斯:研究实施、论文撰写;吴敏、王朝阳、方磊、刘涛、李梅、李环:研究实施;王芳:研究指导、论文修改;汪洋:研究指导、统计学分析、论文修改

D
华中科技大学黄建耿教授团队为本研究提供软件和技术支持
E
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