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ENGLISH ABSTRACT
SPECT及PET探针在特发性肺纤维化中的显像研究进展
刘珺伊
石怡凡
邓晓云
朱小华
作者及单位信息
·
DOI： 10.3760/cma.j.cn321828-20231129-00123
Progress in tracers for SPECT and PET imaging of idiopathic pulmonary fibrosis
Liu Junyi
Shi Yifan
Deng Xiaoyun
Zhu Xiaohua
Authors Info & Affiliations
Liu Junyi
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Shi Yifan
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Deng Xiaoyun
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Zhu Xiaohua
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
·
DOI： 10.3760/cma.j.cn321828-20231129-00123
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摘要

特发性肺纤维化(IPF)是一种病因不清的进行性纤维化性间质性肺病，主要临床表现为进行性加重的呼吸困难伴干咳，其典型病理特征为成纤维细胞的过度活化以及大量细胞外基质的沉积。IPF早期诊断困难，治疗选择有限且存在明显局限性，患者预后不良。SPECT和PET作为分子影像的先进代表，能够在解剖结构出现异常之前反映细胞功能异常，进而实现IPF早期诊断和治疗方案的优化。该文综述了IPF的分子影像靶点及相应的SPECT和PET探针的研究进展。

特发性肺纤维化;分子探针;体层摄影术，发射型计算机，单光子;正电子发射断层显像术;发展趋势
ABSTRACT

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease with an unclear etiology, characterized clinically by worsening dyspnea and dry cough. Its typical pathological features include excessive activation of fibroblasts and deposition of abundant extracellular matrix. Early diagnosis of IPF is challenging, treatment options are limited with significant constraints, and patients have a poor prognosis. SPECT and PET, as advanced representatives of molecular imaging, can reflect cellular functional abnormalities before anatomical structural abnormalities appear, thereby facilitating early diagnosis of IPF and optimization of treatment strategies, leading to improved prognosis. This review summarizes the research progress on molecular imaging targets and corresponding SPECT and PET probes in IPF.

Idiopathic pulmonary fibrosis;Molecular probes;Tomography, emission-computed, single-photon;Positron-emission tomography;Trends
Zhu Xiaohua, Email: mocdef.aabnis.pivuhzave
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引用本文

刘珺伊,石怡凡,邓晓云,等. SPECT及PET探针在特发性肺纤维化中的显像研究进展[J]. 中华核医学与分子影像杂志,2024,44(12)：758-763.

DOI:10.3760/cma.j.cn321828-20231129-00123

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特发性肺纤维化(idiopathic pulmonary fibrosis, IPF)是临床最常见的一种特发性间质性肺炎，主要症状为进行性加重的呼吸困难，常伴干咳 [ 1 ]。全球IPF的发病率和患病率存在较大差异 [ 2 ]，近年来我国IPF病例呈上升趋势 [ 3 ]。
IPF的发病机制尚不明确，曾被认为是炎性反应性疾病，目前认为与早期肺泡上皮细胞的反复损伤和异常修复有关 [ 4 ]，其主要病理特征是成纤维细胞的过度活化以及大量细胞外基质(extracellular matrix, ECM)的沉积 [ 5 ]。目前应用于临床的抗纤维化药物吡非尼酮和尼达尼布仅可减慢IPF患者肺功能下降，而无法消除已形成的纤维化灶，因此该病预后不良，患者确诊后的中位生存期只有3～5年，早期诊断和治疗对患者至关重要 [ 6 ]。高分辨率CT(high resolution CT，HRCT)是目前IPF主要的诊断方法，但其典型征象常在晚期才显现，往往导致最佳干预时机的错过，因此迫切需要研发能够早期识别和监测IPF疾病进展的精准评估手段。
SPECT和PET是分子影像的先进代表，能够在解剖结构出现异常之前发现细胞功能异常。近年来，多种靶向IPF相关靶点的SPECT和PET探针应运而生，这些探针大多针对肺纤维化的典型病理改变(成纤维细胞活化、ECM沉积)、可能的发病机制(炎性反应)及继发改变(血管渗漏、乏氧等)而设计，本文将对相关靶点和对应探针的研究现状进行综述。
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备注信息
A
朱小华，Email: mocdef.aabnis.pivuhzave
B

刘珺伊：文献整理、论文撰写；石怡凡、邓晓云：论文修改；朱小华：研究指导、论文修改及审阅

C
所有作者声明无利益冲突
D
国家重点研发计划 (2021YFC2500703)
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