[综述]
[综述]
阻塞性睡眠呼吸暂停(OSA)是一种常见的睡眠障碍疾病，与青光眼视神经病变、非动脉炎性前部缺血性视神经病变、糖尿病视网膜病变、中心性浆液性脉络膜视网膜病变、视网膜静脉阻塞等多种眼底疾病密切相关。OSA影响眼底疾病的主要机制与间歇性缺氧、交感神经系统激活、全身氧化应激以及炎症反应有关，但具体机制仍待进一步探索。持续气道正压通气治疗可改善OSA患者眼底症状，并降低疾病进展的风险。因此，临床医师需要认识到OSA与眼底疾病之间的相关性，了解其对眼底疾病的影响，进而实现对OSA引起的眼底疾病的早诊断和早治疗，降低视觉受损和致盲的风险。
Obstructive sleep apnea (OSA) is a common sleep disorder that is closely associated with ocular fundus diseases such as glaucomatous optic neuropathy, nonarteritic anterior ischemic optic neuropathy, diabetic retinopathy, central serous chorioretinopathy and retinal vein occlusion.The main mechanisms by which OSA affects fundus diseases include intermittent hypoxia, activation of sympathetic nervous system, systemic oxidative stress, and inflammatory response, but the specific mechanisms require further investigation.The therapeutic modality such as continuous positive airway pressure can alleviate the symptoms of ocular fundus diseases in the patients with OSA and reduce the risk of disease progression.Therefore, clinicians should recognize the relationship between OSA and fundus diseases, understand the impact of OSA on these diseases, and achieve early diagnosis and treatment of the OSA-associated fundus diseases to reduce the risk of severe visual impairment and blindness.
庞雪艺,曹云山,张琰. 阻塞性睡眠呼吸暂停对眼底疾病影响的研究进展[J]. 中华实验眼科杂志,2025,43(01)：80-86.
DOI:10.3760/cma.j.cn115989-20231124-00183版权归中华医学会所有。
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