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光谱学技术在皮肤恶性肿瘤诊断中的研究进展
赵舒文
张景展
康晓静
作者及单位信息
·
DOI： 10.3760/cma.j.cn321828-20240125-00036
Research progress of spectroscopic techniques in the diagnosis of skin malignant tumors
Zhao Shuwen
Zhang Jingzhan
Kang Xiaojing
Authors Info & Affiliations
Zhao Shuwen
Graduate School of Xinjiang Medical University, Urumqi 830001, China
Zhang Jingzhan
Dermatology and Venereology Medical Diagnosis and Treatment Center, People′s Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Clinical Research Center for Dermatology and Venereology; Xinjiang Key Laboratory of Dermatology Research, Urumqi 830001, China
Kang Xiaojing
Dermatology and Venereology Medical Diagnosis and Treatment Center, People′s Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Clinical Research Center for Dermatology and Venereology; Xinjiang Key Laboratory of Dermatology Research, Urumqi 830001, China
·
DOI： 10.3760/cma.j.cn321828-20240125-00036
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摘要

皮肤恶性肿瘤多发生在光暴露部位。早期诊断并治疗可有效提高患者的生存率。组织病理学检查是临床诊断皮肤恶性肿瘤的"金标准"，但该检查是一种侵入性操作，耗时较长且可能出现切口感染、瘢痕形成等风险。近年来，光谱学技术迅速发展，光谱学检测具有非侵入、操作简便、实时检测、高灵敏度等特点，已逐渐应用于皮肤恶性肿瘤的辅助诊断中。该文综述荧光光谱、拉曼光谱、红外光谱等光谱学技术在皮肤恶性肿瘤诊断中的最新研究进展。

皮肤肿瘤;光谱法，荧光;光谱分析，拉曼;谱学，近红外线;发展趋势
ABSTRACT

Skin malignant tumors mostly occur in the light exposure site. Early diagnosis and treatment can effectively improve the survival rate of patients. Histopathological examination is the gold standard for clinical diagnosis of skin malignant tumors, but this method is an invasive operation which brings pain to patients and takes a long time, and may cause problems such as incision infection and scar formation. In recent years, spectroscopy technology has developed rapidly. It is a non-invasive real-time detection method, which can be simply operated, and has a high sensitivity. It has been gradually applied to the diagnosis of skin malignant tumors. This paper reviews the application progress of spectroscopy technology, including fluorescence spectroscopy, Raman spectroscopy and infrared spectroscopy in the diagnosis of skin malignant tumors.

Skin neoplasms;Spectrometry, fluorescence;Spectrum analysis, Raman;Spectroscopy, near-infrared;Trends
Kang Xiaojing, Email: mocdef.3ab61666jxgnakrd
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引用本文

赵舒文,张景展,康晓静. 光谱学技术在皮肤恶性肿瘤诊断中的研究进展[J]. 中华核医学与分子影像杂志,2025,45(02)：125-128.

DOI:10.3760/cma.j.cn321828-20240125-00036

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皮肤恶性肿瘤是常见的恶性肿瘤之一，主要包括基底细胞癌(basal cell carcinoma, BCC)、鳞状细胞癌(squamous cell carcinoma, SCC)、恶性黑色素瘤(malignant melanoma, MM)等 [ 1 ]。皮肤组织病理是诊断皮肤恶性肿瘤的"金标准"，但是皮肤组织病理检查操作流程复杂，基层医院难以开展，同时具有滞后性和有创性，不利于病情实时监测。多种非侵入性成像方法如皮肤镜、皮肤超声等已被应用到皮肤肿瘤的辅助诊断，但检查结果主观性强，在很大程度上依赖于医师的专业技术水平，特别是对于缺乏显著特征的早期皮肤肿瘤，误诊、漏诊率高 [ 2 ]。
近年来光谱学技术迅速发展，已逐渐应用于皮肤肿瘤的检测中 [ 3 ]。光谱学技术可利用细胞和组织的荧光、散射和吸收特性，收集和处理皮肤组织多个位置生物标志物的光谱信息，进行定性、定量和结构分析，有效鉴别恶性肿瘤、癌前病变和良性病理变化特征，从而有助于皮肤肿瘤的监测、诊断、手术边界评价、治疗及术后评估。同时，光谱技术属无创检测，操作便捷，可以更方便地应用于临床。本文对目前光谱学技术在皮肤肿瘤领域研究的最新进展进行综述，以期为皮肤肿瘤早期诊断及相关设备的研发提供参考。
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备注信息
A
康晓静，Email: mocdef.3ab61666jxgnakrd
B

赵舒文：文献检索、论文撰写；张景展：论文修改；康晓静：研究指导、论文修改、经费支持

C
所有作者声明无利益冲突
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新疆维吾尔自治区自然科学基金 (2022D01D23)
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