To better reflect the current status and key research trends in oral medicine research of China and to enhance the overall research abilities in this field, this special issue on oral medicine research integrates the work of several young academic leaders from oral medicine research centers nationwide. Their work focuses on key areas such as artificial intelligence-assisted diagnosis, the pathogenic mechanisms of intracellular bacteria, the relations between oral mucosal diseases and systemic diseases, as well as the study and reporting of rare and unique cases, aligning with the forefront of biomedical research. Although it does not encompass all the high-level researches conducted in China, it presents a rich and diverse array of academic achievements. Those achievements of researches reflect that it is important to further advance interdisciplinary and cross-disciplinary research collaborations, particularly by strengthening cooperation with engineering and technological disciplines in the future. We also need to set sights on driving researches in novel pathogenesis mechanisms of oral mucosal diseases, exploring innovative diagnostic technologies, enhancing diagnostic accuracy and treatment efficacy, and developing new effective intervention strategies. Additionally, greater emphases will be placed on ensuring the accuracy, comprehensiveness, readability, and scientific rigor of case studies and reports to promote sustained progress in this field.