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ENGLISH ABSTRACT
基于Citespace的国内外Laugier-Hunziker综合征研究进展与前沿分析
赵毛毛
王翔
王文梅
作者及单位信息
·
DOI： 10.3760/cma.j.cn112144-20250116-00019
Research progress and frontier analysis of Laugier-Hunziker syndrome at home and abroad based on Citespace
Zhao Maomao
Wang Xiang
Wang Wenmei
Authors Info & Affiliations
Zhao Maomao
Department of Preventive Dentistry, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
Wang Xiang
Department of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
Wang Wenmei
Department of Oral Medicine, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
·
DOI： 10.3760/cma.j.cn112144-20250116-00019
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摘要

目的通过文献计量学方法分析口腔罕见病Laugier-Hunziker综合征（LHS）的概况、变化趋势、热点与前沿。

方法检索中国知网和Web of Science核心合集数据库（WOSCC），中文相关文献统计时间为1992年1月至2023年12月，英文文献相关文献统计时间为1986年1月至2023年12月。利用Citespace软件对文献的发文量、作者、国家、机构、期刊和关键词等多个方面进行可视化分析。

结果本研究共纳入了112篇文献（25篇中文文献和87篇英文文献），总体发文量呈波动式缓慢增长趋势。国外作者Lenane P和Powell F是发文最多的作者。国内作者来自中国医学科学院北京协和医院的团队发文最多。从国家间的合作来看，美国的中心性最高，但世界各地的合作网络却较松散。University College Dublin是国外发文量最高的机构，国内发文最多的机构为中国医学科学院北京协和医院。国外发表关于LHS论文最多的期刊为 Journal of The American Academy of Dermatology，国内则是《中国麻风皮肤病杂志》。LHS的研究热点包括病损部位、鉴别诊断，研究前沿则包括鉴别诊断、疾病管理和口腔黏膜相关临床表现方面。

结论LHS研究呈现聚焦鉴别诊断和症状管理的趋势。未来研究应加强优化治疗手段并注重心理支持，同时推动跨学科协作和全球研究网络整合，以提升临床诊疗水平。

文献计量学;Laugier-Hunziker综合征;可视化;知识图谱
ABSTRACT

ObjectiveAnalyzing the overview, changing trends, hotspots, and frontiers of the rare oral disease Laugier-Hunziker syndrome (LHS) using bibliometrics.

MethodsSearch the CNKI (China National Knowledge Infrastructure) and Web of science core collection (WOSCC) databases. The time span for Chinese literature is from January 1992 to December 2023, and for English literature is from January 1986 to December 2023. Utilize Citespace software to conduct visualized analysis on various aspects of the literature, including publication volume, authors, countries, institutions, journals, and keywords.

ResultsThis study included a total of 112 articles (25 in Chinese and 87 in English). The overall publication volume showed a fluctuating slow-growth trend. Foreign authors Lenane P and Powell F had the highest number of publications. The team from Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, had the most publications among domestic authors. In terms of international collaboration, the United States demonstrated the highest centrality, but the collaborative network worldwide appeared relatively loose. University College Dublin was the foreign institution with the highest publication volume, while Peking Union Medical College Hospital was the domestic institution with the most publications. The journal with the highest number of foreign publications was the Journal of The American Academy of Dermatology, and the journal with the most domestic publications was the Chinese Leprosy Skin Disease Journal. Research hotspots for Laugier-Hunziker syndrome included lesion sites and differential diagnosis, while the frontiers of research encompassed differential diagnosis, disease management, and clinical manifestations related to oral mucosa.

ConclusionsLaugier-Hunziker syndrome research shows a focus on differential diagnosis and symptom management. Future studies should prioritize optimizing treatment methods and emphasizing psychological support, while promoting interdisciplinary collaboration and the integration of global research networks to improve clinical diagnostic and therapeutic outcomes.

Bibliometrics;Laugier-Hunziker syndrome;Visualization;Knowledge graph
Wang Wenmei, Email: mocdef.3ab612010iemnewgnaw, Tel: 0086-25-83632991
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引用本文

赵毛毛,王翔,王文梅. 基于Citespace的国内外Laugier-Hunziker综合征研究进展与前沿分析[J]. 中华口腔医学杂志,2025,60(03)：273-281.

DOI:10.3760/cma.j.cn112144-20250116-00019

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Laugier-Hunziker综合征（Laugier-Hunziker syndrome，LHS）是口腔罕见病名录中第34位口腔罕见病 ［ 1 ］ 。它是一种罕见的后天性疾病，表现为口腔黏膜或其他黏膜弥漫性色素斑，皮肤和指甲受累的情况也较常见 ［ 2 ］ 。LHS作为一种罕见的后天性疾病，患病率较低，呈现为慢性过程，LHS的确切病因尚不清楚 ［ 3 ］ ，亦未明确潜在疾病或系统异常 ［ 4 , 5 ］ 。LHS的主要特征是口腔黏膜的黑色素沉着，通常出现在口腔颊黏膜和舌体上。此外，指（趾）甲上的黑色素沉着也是该综合征的典型表现之一。鉴别诊断时需排除其他潜在的恶性病变。目前针对LHS尚无明确的治疗标准。治疗主要侧重于症状的管理和患者的心理支持。口腔黏膜的黑色素沉着可通过激光治疗、手术切除和光动力疗法等方法进行减轻或去除。针对病情严重或产生不适的患者，心理咨询和支持也是治疗的重要组成部分。LHS通常是一种良性疾病，大多数患者的病情相对稳定且没有其他严重并发症。早期正确的临床诊断对于排除恶性的色素疾病，避免使用过度检查和治疗十分重要。然而，临床医师对LHS的认知和诊治水平亟待提升。
为了全面深入认识罕见病LHS，了解其研究热点和前沿，本研究使用Citespace文献计量软件对中国知网Web of Science核心合集（Web of Science core collection，WOSCC）数据库中提取的有效文献以计量学方法量化直观展示该疾病的临床研究进展，Citespace是一款数字化、信息化和智能化的软件工具，可用于文献数据的可视化分析。该软件提供多种数据分析和可视化功能，如关键词共现分析、作者合作网络分析等，为提升LHS诊疗水平和进一步研究提供参考。
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备注信息
A
王文梅，Email： mocdef.3ab612010iemnewgnaw，电话：025-83632991
B

赵毛毛：研究设计和实施、数据分析、论文撰写及修改；王翔：指导研究设计、数据分析、论文初稿撰写；王文梅：研究的主要构思者，指导研究设计，论文撰写及修改

C
赵毛毛, 王翔, 王文梅. 基于Citespace的国内外Laugier-Hunziker综合征研究进展与前沿分析[J]. 中华口腔医学杂志, 2025, 60(3): 273-281. DOI: 10.3760/cma.j.cn112144-20250116-00019.
D
所有作者声明不存在利益冲突
E
国家自然科学基金 (81870767)
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