To establish diagnosis, treatment management pathways, and quality control guidelines tailored to county-level hospitals, standardize ovarian cancer care, improve treatment quality, and promote the equitable distribution of high-quality medical resources, the Expert Committee on Ovarian Cancer under the National Cancer Quality Control Center formulated the " Guidelines for diagnosis, treatment management pathways, and quality control of ovarian cancer in county-level regions (2025 edition)". This guideline integrates existing national standards for ovarian cancer diagnosis and treatment with evidence-based medicine and clinical expertise. Structured as a pathway framework, this guideline addresses hierarchical diagnosis and treatment, diagnostic workflows, therapeutic approaches, and follow-up protocols for ovarian cancer in county-level settings, offering 13 specific recommendations. The guideline clarifies the roles of county-level hospitals in ovarian cancer management, including primary diagnosis and treatment, administration of antitumor therapies, maintenance therapy, adverse event management, recurrence monitoring, rehabilitation guidance, two-way referrals, and follow-up. For cases beyond local capacity, timely referral to higher-level hospitals or qualified county-level facilities is advised. County-level hospitals may perform surgery for early-stage ovarian cancer, but suspected advanced-stage cases should be promptly referred. The guideline emphasizes the importance of multidisciplinary collaboration in county-level hospitals and recommend that initial chemotherapy for newly diagnosed patients should be conducted at higher-level or adequately equipped county-level institutions. Follow-up evaluations may be performed locally, but suspected recurrence or metastasis requires referral to higher-level hospitals for assessment. Detailed pathways are provided for diagnosis, treatment (including surgery, chemotherapy, maintenance therapy, and recurrence management), and follow-up, with recommendations for incorporating online follow-up methods to enhance patient monitoring. By defining the roles of county-level hospitals, standardizing referral processes, and strengthening multidisciplinary coordination, the guideline aims to promote standardized ovarian cancer care. Its implementation is expected to improve county-level hospitals' diagnostic and therapeutic capabilities, foster collaboration with higher-level institutions, and ultimately enhance patient outcomes and quality of life. These efforts will optimize medical resource allocation, elevate national ovarian cancer care standards, and advance balanced regional healthcare development.