准确可靠地评估严重脑损伤患者的意识水平和内容是临床面临的重大难题之一。脑外伤、脑卒中、缺氧性脑病等原因导致的慢性意识障碍患者越来越多，如何正确地诊断意识障碍类型，进行个体化干预、合理护理，减少发病率和病残率，是目前临床亟待解决的重要问题。神经影像学在慢性意识障碍分型、治疗及伦理管理方面发挥着重要作用，快速发展的影像学技术与先进的数据分析为探测大脑活动开辟了新的视野，但从大量可用的影像技术中选择合适的成像模式及合理的图像解读对临床医师来说是一项挑战。该文综述了多模态神经影像在慢性意识障碍评估中的应用进展，还讨论了其与意识障碍的临床相关性和转化潜力。
Accurately assessing the level and content of consciousness in patients with severe brain injury is one of the major clinical challenges. Patients with prolonged disorders of consciousness (DoC) caused by various reasons including brain trauma, stroke, hypoxic encephalopathy, are increasing. Correct diagnosis of DoC is of great significance for individualized intervention, reasonable nursing, and reduction of incidence rate and disability rate. Neuroimaging plays an important role in the classification, treatment, and ethical management of prolonged DoC. The rapidly developing imaging technology and advanced data analysis have opened up new perspectives for detecting brain activity. However, selecting appropriate imaging and reasonable image interpretation from a large number of available imaging technologies is a challenge for clinicians. This article reviews the application progress of multimodal neuroimaging in the assessment of prolonged DoC, and the clinical relevance and translational potential of these advances in assessing DoC are also discussed.
郭坤,汪静. 多模态影像在慢性意识障碍分型中的临床应用及研究进展[J]. 中华核医学与分子影像杂志,2025,45(03)：189-192.
DOI:10.3760/cma.j.cn321828-20240302-00080版权归中华医学会所有。
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