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ENGLISH ABSTRACT
上颌前牙区垂直向骨缺损的软组织管理决策
王妙贞
刘峰
陈江
赵伟
作者及单位信息
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DOI: 10.3760/cma.j.cn112144-20250108-00006
Soft tissue management of severe bone defect in the maxillary anterior area: a clinical guideline on the decision-making process
Wang Miaozhen
Liu Feng
Chen Jiang
Zhao Wei
Authors Info & Affiliations
Wang Miaozhen
First Clinical Division, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing 100034, China
Liu Feng
First Clinical Division, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing 100034, China
Chen Jiang
Department of Implantology, School and Hospital of Stomatology, Fujian Medical University & Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University & Institute of Stomatology, Fujian Medical University & Research Center of Dental and Craniofacial Implants, Fujian Medical University, Fuzhou 350025, China
Zhao Wei
Department of Implantology, School and Hospital of Stomatology, Fujian Medical University & Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University & Institute of Stomatology, Fujian Medical University & Research Center of Dental and Craniofacial Implants, Fujian Medical University, Fuzhou 350025, China
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DOI: 10.3760/cma.j.cn112144-20250108-00006
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摘要

上颌前牙区垂直向骨增量是相对复杂,技术敏感性高的手术,选择恰当的软组织管理策略不可或缺,以避免短期和长期并发症。本文主要论述两个方面:①垂直向骨增量手术中,根据不同软组织的质和量,进行切口和翻瓣设计。对于质量俱佳的黏膜,采用梯形瓣切口设计,应用骨膜延展技术进行减张;对于过浅的前庭沟,采用更大范围的梯形瓣,应用黏膜-口轮匝肌分离的减张方式,以及龈乳头错位缝合保证创面的一期关闭;对于黏膜菲薄或存在黏膜穿孔的情况,通过带蒂骨膜瓣进行修补。②二期手术选择恰当的软组织增量术式,改善美学效果,以期为临床医师提供治疗参考。对于水平向软组织缺损,采用结缔组织移植或腭侧带蒂翻转瓣进行处理;对于垂直向软组织缺损,采用冰山技术或蝴蝶结技术等进行垂直向增量;对于水平向联合垂直向缺损,采用结缔组织平台技术进行三维软组织重建。

美学,牙科;牙种植;垂直骨增量;软组织移植;治疗决策
ABSTRACT

Vertical bone augmentation (VBA) in the anterior maxilla is a technically and biologically challenging technique with high complication rates and unpredictable outcomes. Selecting appropriate soft tissue management strategies is crucial to avoid short-term and long-term complications. This article aims to assist clinicians in making treatment decisions based on different soft tissue conditions during VBA. It is divided into two parts. Incision and flap design based on the quality and quantity of different soft tissues during VBA. For mucosa of good quality and quantity, a trapezoidal flap incision design is adopted, and the periosteum extension technique is applied for tension reduction. For a shallow vestibular sulcus, a larger trapezoidal flap is used, and the tension reduction method of mucosa-oralis muscle separation is applied, along with papilla transposition suture to ensure primary wound closure. For thin mucosa or with perforating defects, a pedicled periosteal flap is used for repair. Selection of appropriate soft tissue augmentation techniques during the second-stage surgery based on the soft tissue status to improve esthetic outcomes. For horizontal soft tissue defects, free connective tissue graft (CTG) or palatal pedicled flap can be used for treatment; for vertical soft tissue defects, techniques such as the iceberg technique or customized CTG with bowtie-like shape can be used for vertical augmentation; for combined horizontal and vertical defects, the connective tissue platform technique can be used for three-dimensional soft tissue reconstruction.

Esthetics, dental;Dental implantation;Vertical bone augmentation;Soft tissue augmentation;Decision tree
Liu Feng, Email: mocdef.6ab21gnefuiltsitned, Tel: 0086-10-53295228
引用本文

王妙贞,刘峰,陈江,等. 上颌前牙区垂直向骨缺损的软组织管理决策[J]. 中华口腔医学杂志,2025,60(04):340-346.

DOI:10.3760/cma.j.cn112144-20250108-00006

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牙列长期缺损、牙列发育异常、重度牙周炎、外伤、肿瘤切除术后等原因均可造成上颌前牙区牙槽骨垂直向缺损 1,进而导致种植体难以植于理想的三维位置;或因种植体植入过深导致种植修复体冠根比不协调,出现美学及功能相关的问题 2。此时需对患者行垂直向骨增量(vertical bone augmentation,VBA) 3。与水平向骨增量相比,VBA技术敏感性高,出现并发症的概率较大,尤其是伤口裂开率较高(0~45%) 4 , 5 , 6 , 7 , 8 , 9。由于植骨可增加术区体积,术者需推进更多的软组织覆盖术区,而VBA患者软组织的质和量通常较差,因此大大提高伤口裂开的风险。伤口裂开可导致移植物供血不足、新生毛细血管网重建延迟、植骨材料部分或完全吸收甚至感染及种植体周围骨吸收,从而影响植骨的预后和种植体存留率 10 , 11 , 12。因此,VBA过程中恰当的软组织瓣管理和无张力的伤口关闭是影响手术成功的关键 13。软组织的质和量除影响VBA成败外,还可影响种植修复体粉白美学效果的最终呈现。种植修复治疗的主要美学目标是保持或重建获得饱满的牙槽轮廓、获得和谐的牙龈曲线、无明显的黏膜退缩以及保持龈乳头完整 14。现从以下两方面展开论述:①骨增量手术中,根据不同软组织的质和量,进行切口和翻瓣设计;②二期手术中选择恰当的软组织增量术式,改善术后美学效果,以期协助临床医师在VBA过程中根据不同软组织条件进行治疗决策。
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参考文献
[1]
Stricker A , Jacobs R , Maes F ,et al. Resorption of retromolar bone grafts after alveolar ridge augmentation-volumetric changes after 12 months assessed by CBCT analysis[J]. Int J Implant Dent, 2021,7(1):7. DOI: 10.1186/s40729-020-00285-9 .
返回引文位置Google Scholar
百度学术
万方数据
[2]
Buser D , Urban I , Monje A ,et al. Guided bone regeneration in implant dentistry: basic principle, progress over 35 years, and recent research activities[J]. Periodontol 2000, 2023,93(1):9-25. DOI: 10.1111/prd.12539 .
返回引文位置Google Scholar
百度学术
万方数据
[3]
Rocchietta I , Ferrantino L , Simion M . Vertical ridge augmentation in the esthetic zone[J]. Periodontol 2000, 2018,77(1):241-255. DOI: 10.1111/prd.12218 .
返回引文位置Google Scholar
百度学术
万方数据
[4]
尉华杰,朱一博,邱立新. 双层皮质骨片夹层植骨技术对上前牙重度骨缺损患者成骨效果的长期临床观察[J]. 中华口腔医学杂志, 2020,55(11):838-844. DOI: 10.3760/cma.j.cn112144-20200623-00362 .
返回引文位置Google Scholar
百度学术
万方数据
Yu HJ , Zhu YB , Qiu LX . Clinical study on bilamina cortical grafting technique for reconstruction of severely atrophic alveolar ridges in anterior maxillae[J]. Chin J Stomatol, 2020,55(11):838-844. DOI: 10.3760/cma.j.cn112144-20200623-00362 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[5]
肖闻澜,胡琛,柳叶语,. 牙本质壳技术治疗牙缺失伴严重骨缺损一例报告[J]. 中国口腔种植学杂志, 2021,26(1):40-43. DOI: 10.12337/zgkqzzxzz.2021.02.009 .
返回引文位置Google Scholar
百度学术
万方数据
Xiao WL , Hu C , Liu YY ,et al. Dentin shell technique for the treatment of severe alveolar bone defect at the edentulous site[J]. Chin J Oral Implantol, 2021,26(1):40-43. DOI: 10.12337/zgkqzzxzz.2021.02.009 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[6]
Cucchi A , Maiani F , Franceschi D ,et al. The influence of vertical ridge augmentation techniques on peri-implant bone loss: a systematic review and meta-analysis[J]. Clin Implant Dent Relat Res, 2024,26(1):15-65. DOI: 10.1111/cid.13282 .
返回引文位置Google Scholar
百度学术
万方数据
[7]
Cucchi A , Maiani F , Franceschi D ,et al. The influence of vertical ridge augmentation techniques on peri-implant bone loss: a systematic review and meta-analysis[J]. Clin Implant Dent Relat Res, 2024,26(1):15-65. DOI: 10.1111/cid.13282 .
返回引文位置Google Scholar
百度学术
万方数据
[8]
Cucchi A , Vignudelli E , Napolitano A ,et al. Evaluation of complication rates and vertical bone gain after guided bone regeneration with non-resorbable membranes versus titanium meshes and resorbable membranes. A randomized clinical trial[J]. Clin Implant Dent Relat Res, 2017,19(5):821-832. DOI: 10.1111/cid.12520 .
返回引文位置Google Scholar
百度学术
万方数据
[9]
Urban IA , Montero E , Monje A ,et al. Effectiveness of vertical ridge augmentation interventions: a systematic review and meta-analysis[J]. J Clin Periodontol, 2019,46:Suppl 21-319. 339DOI: 10.1111/jcpe.13061 .
返回引文位置Google Scholar
百度学术
万方数据
[10]
Poli PP , Beretta M , Maiorana C ,et al. Therapeutic strategies in the management of nonresorbable membrane and titanium mesh exposures following alveolar bone augmentation: a systematic scoping review[J]. Int J Oral Maxillofac Implants, 2022,37(2):250-269. DOI: 10.11607/jomi.9286 .
返回引文位置Google Scholar
百度学术
万方数据
[11]
Urban I , Sanz-Sánchez I , Monje A ,et al. Complications and treatment errors in peri-implant hard tissue management[J]. Periodontol 2000, 2023,92(1):278-298. DOI: 10.1111/prd.12472 .
返回引文位置Google Scholar
百度学术
万方数据
[12]
von Arx T , Hardt N , Wallkamm B . The TIME technique: a new method for localized alveolar ridge augmentation prior to placement of dental implants[J]. Int J Oral Maxillofac Implants, 1996,11(3):387-394.
返回引文位置Google Scholar
百度学术
万方数据
[13]
Jepsen S , Schwarz F , Cordaro L ,et al. Regeneration of alveolar ridge defects. Consensus report of group 4 of the 15th European Workshop on Periodontology on Bone Regeneration[J]. J Clin Periodontol, 2019,46:Suppl 21-277. 286DOI: 10.1111/jcpe.13121 .
返回引文位置Google Scholar
百度学术
万方数据
[14]
Jensen SS , Aghaloo T , Jung RE ,et al. Group 1 ITI Consensus Report: the role of bone dimensions and soft tissue augmentation procedures on the stability of clinical, radiographic, and patient-reported outcomes of implant treatment[J]. Clin Oral Implants Res, 2023,34:Suppl 26-43. 49DOI: 10.1111/clr.14154 .
返回引文位置Google Scholar
百度学术
万方数据
[15]
Urban IA , Montero E , Monje A ,et al. Effectiveness of vertical ridge augmentation interventions: a systematic review and meta-analysis[J]. J Clin Periodontol, 2019,46:Suppl 21-319. 339DOI: 10.1111/jcpe.13061 .
返回引文位置Google Scholar
百度学术
万方数据
[16]
Urban IA , Montero E , Amerio E ,et al. Techniques on vertical ridge augmentation: indications and effectiveness[J]. Periodontol 2000, 2023,93(1):153-182. DOI: 10.1111/prd.12471 .
返回引文位置Google Scholar
百度学术
万方数据
[17]
Urban IA , Saleh M , Ravidà A ,et al. Vertical bone augmentation utilizing a titanium-reinforced PTFE mesh: a multi-variate analysis of influencing factors[J]. Clin Oral Implants Res, 2021,32(7):828-839. DOI: 10.1111/clr.13755 .
返回引文位置Google Scholar
百度学术
万方数据
[18]
Blal K , Alterman M , Abu Tair J . A pedicled palatal periosteal flap for the closure of oro-antral fistula[J]. Int J Oral Maxillofac Surg, 2020,49(8):1087-1091. DOI: 10.1016/j.ijom.2020.01.014 .
返回引文位置Google Scholar
百度学术
万方数据
[19]
Rosenfeld EA . Inverted periosteal flap: an alternative to the buccal advancement flap for tension-free, watertight closure[J]. J Oral Maxillofac Surg, 2014,72(7):1244-1250. DOI: 10.1016/j.joms.2014.03.006 .
返回引文位置Google Scholar
百度学术
万方数据
[20]
Monje A , González-Martín O , Ávila-Ortiz G . Impact of peri-implant soft tissue characteristics on health and esthetics[J]. J Esthet Restor Dent, 2023,35(1):183-196. DOI: 10.1111/jerd.13003 .
返回引文位置Google Scholar
百度学术
万方数据
[21]
Carbone AC , Joly JC , Botelho J ,et al. Long-term stability of gingival margin and periodontal soft-tissue phenotype achieved after mucogingival therapy: a systematic review[J]. J Clin Periodontol, 2024,51(2):177-195. DOI: 10.1111/jcpe.13900 .
返回引文位置Google Scholar
百度学术
万方数据
[22]
Galarraga-Vinueza ME , Tavelli L . Soft tissue features of peri-implant diseases and related treatment[J]. Clin Implant Dent Relat Res, 2023,25(4):661-681. DOI: 10.1111/cid.13156 .
返回引文位置Google Scholar
百度学术
万方数据
[23]
Zuiderveld EG , Meijer H , den Hartog L ,et al. Effect of connective tissue grafting on peri-implant tissue in single immediate implant sites: a RCT[J]. J Clin Periodontol, 2018,45(2):253-264. DOI: 10.1111/jcpe.12820 .
返回引文位置Google Scholar
百度学术
万方数据
[24]
Ferrari M , Carrabba M , Vichi A ,et al. Influence of abutment color and mucosal thickness on soft tissue color[J]. Int J Oral Maxillofac Implants, 2017,32(2):393-399. DOI: 10.11607/jomi.4794 .
返回引文位置Google Scholar
百度学术
万方数据
[25]
Quispe-López N , Gómez-Polo C , Zubizarreta-Macho Á ,et al. How do the dimensions of peri-implant mucosa affect marginal bone loss in equicrestal and subcrestal position of implants? A 1-year clinical trial[J]. Clin Implant Dent Relat Res, 2024,26(2):442-456. DOI: 10.1111/cid.13306 .
返回引文位置Google Scholar
百度学术
万方数据
[26]
Terzioglu B , Ayyildiz BG . Effect of supracrestal tissue height on marginal bone level changes at platform-switching dental implants placed crestally and subcrestally: a randomized clinical-trial[J]. J Dent, 2024,148:105219. DOI: 10.1016/j.jdent.2024.105219 .
返回引文位置Google Scholar
百度学术
万方数据
[27]
Sanz M , Schwarz F , Herrera D ,et al. Importance of keratinized mucosa around dental implants: consensus report of group 1 of the DGI/SEPA/Osteology Workshop[J]. Clin Oral Implants Res, 2022,33:Suppl 23-47. 55DOI: 10.1111/clr.13956 .
返回引文位置Google Scholar
百度学术
万方数据
[28]
Gobbato L , Avila-Ortiz G , Sohrabi K ,et al. The effect of keratinized mucosa width on peri-implant health: a systematic review[J]. Int J Oral Maxillofac Implants, 2013,28(6):1536-1545. DOI: 10.11607/jomi.3244 .
返回引文位置Google Scholar
百度学术
万方数据
[29]
Souza AB , Tormena M , Matarazzo F ,et al. The influence of peri-implant keratinized mucosa on brushing discomfort and peri-implant tissue health[J]. Clin Oral Implants Res, 2016,27(6):650-655. DOI: 10.1111/clr.12703 .
返回引文位置Google Scholar
百度学术
万方数据
[30]
van Brakel R , Noordmans HJ , Frenken J ,et al. The effect of zirconia and titanium implant abutments on light reflection of the supporting soft tissues[J]. Clin Oral Implants Res, 2011,22(10):1172-1178. DOI: 10.1111/j.1600-0501.2010.02082.x .
返回引文位置Google Scholar
百度学术
万方数据
[31]
Thoma DS , Gasser T , Hämmerle C ,et al. Soft tissue augmentation with a volume-stable collagen matrix or an autogenous connective tissue g raft at implant sites: five-year results of a randomized controlled trial post implant loading [J]. J Periodontol, 2023,94(2):230-243. DOI: 10.1002/JPER.22-0226 .
返回引文位置Google Scholar
百度学术
万方数据
[32]
Thoma DS , Naenni N , Figuero E ,et al. Effects of soft tissue augmentation procedures on peri-implant health or disease: a systematic review and meta-analysis[J]. Clin Oral Implants Res, 2018,29:Suppl 15-32. 49DOI: 10.1111/clr.13114 .
返回引文位置Google Scholar
百度学术
万方数据
[33]
Pohl S , Salama M , Petrakakis P . Buccal sliding palatal pedicle flap technique for wound closure after ridge augmentation[J]. Int J Periodontics Restorative Dent, 2020,40(5):741-747. DOI: 10.11607/prd.4544 .
返回引文位置Google Scholar
百度学术
万方数据
[34]
Scharf DR , Tarnow DP . Modified roll technique for localized alveolar ridge augmentation[J]. Int J Periodontics Restorative Dent, 1992,12(5):415-425.
返回引文位置Google Scholar
百度学术
万方数据
[35]
Urban I . Vertical 2: The next level of hard and soft tissue augmentation[M]. Berlin:Quintessenz Verlags-GmbH, 2022.
[36]
Yi Z , Miao X , Wang L ,et al. A customized subepithelial connective tissue graft for interdental papilla reconstruction and soft tissue augmentation[J]. J Esthet Restor Dent, 2022,34(3):451-460. DOI: 10.1111/jerd.12858 .
返回引文位置Google Scholar
百度学术
万方数据
[37]
Zucchelli G , Mazzotti C , Bentivogli V ,et al. The connective tissue platform technique for soft tissue augmentation[J]. Int J Periodontics Restorative Dent, 2012,32(6):665-675.
返回引文位置Google Scholar
百度学术
万方数据
[38]
Mazzotti C , Stefanini M , Felice P ,et al. Soft-tissue dehiscence coverage at peri-implant sites[J]. Periodontol 2000, 2018,77(1):256-272. DOI: 10.1111/prd.12220 .
返回引文位置Google Scholar
百度学术
万方数据
[39]
Zuhr O , Hurzeler M . 牙周与种植美学成形手术显微外科理念与技术[M]. 陈波,. 北京:人民军医出版社, 2016.
Zuhr O , Hurzeler M . Microsurgery concepts and techniques for periodontal and implant aesthetic shaping surgery[M]. Chen B ,trans. Beijing:People′s Military Medical Press, 2016.
[40]
Urban I , Montero E , Sanz-Sánchez I ,et al. Minimal invasiveness in vertical ridge augmentation[J]. Periodontol 2000, 2023,91(1):126-144. DOI: 10.1111/prd.12479 .
返回引文位置Google Scholar
百度学术
万方数据
[41]
Sáez-Alcaide LM , González Gallego B , Fernando Moreno J ,et al. Complications associated with vertical bone augmentation techniques in implant dentistry: a systematic review of clinical studies published in the last ten years[J]. J Stomatol Oral Maxillofac Surg, 2023,124(6S):101574. DOI: 10.1016/j.jormas.2023.101574 .
返回引文位置Google Scholar
百度学术
万方数据
[42]
Poomprakobsri K , Kan JY , Rungcharassaeng K ,et al. Exposure of barriers used in guided bone regeneration: rate, timing, management, and effect on grafted bone-a retrospective analysis[J]. J Oral Implantol, 2022,48(1):27-36. DOI: 10.1563/aaid-joi-D-19-00252 .
返回引文位置Google Scholar
百度学术
万方数据
[43]
Sanz-Sánchez I , Sanz-Martín I , Ortiz-Vigón A ,et al. Complications in bone-grafting procedures: classification and management[J]. Periodontol 2000, 2022,88(1):86-102. DOI: 10.1111/prd.12413 .
返回引文位置Google Scholar
百度学术
万方数据
[44]
Zhang M , Zhou Z , Yun J ,et al. Effect of different membranes on vertical bone regeneration: a systematic review and network meta-analysis[J]. Biomed Res Int, 2022,2022:7742687. DOI: 10.1155/2022/7742687 .
返回引文位置Google Scholar
百度学术
万方数据
[45]
El Morsy OA , Barakat A , Mekhemer S ,et al. Assessment of 3-dimensional bone augmentation of severely atrophied maxillary alveolar ridges using patient-specific poly ether-ether ketone (PEEK) sheets[J]. Clin Implant Dent Relat Res, 2020,22(2):148-155. DOI: 10.1111/cid.12890 .
返回引文位置Google Scholar
百度学术
万方数据
[46]
Sakr MI , Hanafy M , Gibaly A ,et al. Digital workflow for graft harvest and positioning in deficient anterior mandibles versus conventional technique: randomized controlled trial[J]. Clin Implant Dent Relat Res, 2024,26(6):1209-1220. DOI: 10.1111/cid.13382 .
返回引文位置Google Scholar
百度学术
万方数据
[47]
Cucchi A , Bettini S , Tedeschi L ,et al. Complication, vertical bone gain, volumetric changes after vertical ridge augmentation using customized reinforced PTFE mesh or Ti-mesh. A non-inferiority randomized clinical trial[J]. Clin Oral Implants Res, 2024,35(12):1616-1639. DOI: 10.1111/clr.14350 .
返回引文位置Google Scholar
百度学术
万方数据
[48]
De Santis D , Umberto L , Dario D ,et al. Custom bone regeneration (cbr): an alternative method of bone augmentation-a case series study[J]. J Clin Med, 2022,11(16):4739. DOI: 10.3390/jcm11164739 .
返回引文位置Google Scholar
百度学术
万方数据
[49]
陈静霞,周延民,任思聪,. 前牙美学区三维打印个性化钛网骨增量1例[J]. 中华口腔医学杂志, 2024,59(12):1254-1257. DOI: 10.3760/cma.j.cn112144-20240704-00257 .
返回引文位置Google Scholar
百度学术
万方数据
Chen JX , Zhou YM , Ren SC ,et al. A case of bone augmentation using three-dimensional printed individualized titanium mesh in anterior esthetic area[J]. Chin J Stomatol, 2024,59(12):1254-1257. DOI: 10.3760/cma.j.cn112144-20240704-00257 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[50]
Thoma DS , Zeltner M , Hilbe M ,et al. Randomized controlled clinical study evaluating effectiveness and safety of a volume-stable collagen matrix compared to autogenous connective tissue grafts for soft tissue augmentation at implant sites[J]. J Clin Periodontol, 2016,43(10):874-885. DOI: 10.1111/jcpe.12588 .
返回引文位置Google Scholar
百度学术
万方数据
备注信息
A
刘峰,Email: mocdef.6ab21gnefuiltsitned,电话:010-53295228
B

王妙贞:文章撰写;刘峰:撰写指导、文章审核和修改;陈江:思路指导、文章审核和修改;赵伟:文献查阅、文章审核和修改

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王妙贞, 刘峰, 陈江, 等. 上颌前牙区垂直向骨缺损的软组织管理决策[J]. 中华口腔医学杂志, 2025, 60(4): 340-346. DOI: 10.3760/cma.j.cn112144-20250108-00006.
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