目的分析慢性心力衰竭（CHF）合并轻度认知障碍（MCI）患者神经心理学特征，探讨影响CHF合并MCI的相关因素。
方法采用病例对照研究，回顾性分析宝鸡市中医院2019年1月至2020年10月收治的CHF患者98例的临床资料，依据Petersen MCI筛查标准分为MCI组（ n=48）、认知功能正常组（NC组， n=50），用简易智能状态量表（MMSE）、蒙特利尔认知评估量表（MOCA）分析神经心理学特征，测试并比较两组患者的认知域评分，logistic回归分析CHF合并MCI的影响因素。
结果NC组MMSE、MoCA总分分别为（28.45±1.10）分、（27.90±1.35）分，均高于MCI组的（23.50±2.25）分、（22.95±1.35）分（ t=13.92、18.15，均 P < 0.001）；NC组正确阅读数、耗时数、注意力、视空间功能、记忆力、语言功能均优于MCI组（ t=2.94、7.29、3.15、9.90、14.69、4.87，均 P < 0.01）；MCI组年龄 ≥ 65岁、文化程度初中及以下、睡眠障碍、纽约心脏病协会分级Ⅲ级占比均高于NC组（ χ 2=4.18、4.08、6.88、4.70，均 P < 0.05），心输出量（CO）低于NC组（ t=4.70， P < 0.05）；logistic回归分析显示，年龄 ≥ 65岁（ OR=3.904，95% CI：1.530~9.963）、文化程度初中及以下（ OR=2.565，95% CI：1.571~4.187）、睡眠障碍（ OR=3.080，95% CI：1.445~6.564）、CO低（ OR=1.784，95% CI：1.168~2.725）为CHF合并MCI的独立危险因素（均 P < 0.05）。
结论CHF合并MCI患者的视空间功能、执行功能、注意力、语言功能、记忆力区域的损害更多见；年龄 ≥ 65岁、文化程度初中及以下、睡眠障碍、CO低等为CHF合并MCI的独立危险因素。
ObjectiveTo analyze the neuropsychological characteristics of patients with chronic heart failure (CHF) complicated by mild cognitive impairment (MCI) and investigate the factors that influence the development of CHF complicated by MCI.
MethodsA case-control study was conducted to retrospectively analyze the clinical data of 98 patients with CHF admitted to Baoji Hospital of Traditional Chinese Medicine from January 2019 to October 2020. Based on the Petersen MCI screening criteria, the patients were divided into the MCI group ( n = 48) and the normal cognitive group (NC group, n = 50). The neuropsychological characteristics were analyzed using the Mini-Mental State Examination and the Montreal Cognitive Assessment. The cognitive domain scores of the two groups were tested and compared. Logistic regression analysis was performed to identify the factors influencing the development of CHF complicated by MCI.
ResultsThe total scores of the Mini-Mental State Examination and the Montreal Cognitive Assessment in the NC group were 28.45 ± 1.10 and 27.90 ± 1.35, respectively, which were significantly higher than those in the MCI group (23.50 ± 2.25, 22.95 ± 1.35, t = 13.92, 18.15, both P < 0.001). In addition, the NC group outperformed the MCI group in terms of the number of correct readings, time taken, attention, visuospatial function, memory, and language function ( t = 2.94, 7.29, 3.15, 9.90, 14.69, 4.87, all P < 0.01). The MCI group had a greater proportion of patients who were aged ≥ 65 years, had an education level of junior high school or below, experienced sleep disorders, and were classified as New York Heart Association (NYHA) functional class Ⅲ, compared with the NC group ( χ 2 = 4.18, 4.08, 6.88, 4.70, all P < 0.05). Additionally, the cardiac output was lower in the MCI group than in the NC group ( t = 4.70, P < 0.05). Logistic regression analysis revealed that age ≥ 65 years ( OR = 3.904, 95% CI: 1.530-9.963), education level of junior high school or below ( OR = 2.565, 95% CI: 1.571-4.187), sleep disorders ( OR = 3.080, 95% CI: 1.445-6.564), and low cardiac output ( OR = 1.784, 95% CI: 1.168-2.725) were independent risk factors for CHF complicated by MCI ( P < 0.05).
ConclusionsPatients with CHF complicated by MCI are more likely to experience impairments in visuospatial function, executive function, attention, language function, and memory. Independent risk factors for CHF complicated by MCI include age ≥ 65 years, education level of junior high school or below, sleep disorders, and low cardiac output.
冯攀,刘涛,王毅博,等. CHF合并MCI患者神经心理学特征及相关因素分析[J]. 中国基层医药,2025,32(03)：382-386.
DOI:10.3760/cma.j.cn341190-20240618-00759版权归中华医学会所有。
未经授权，不得转载、摘编本刊文章，不得使用本刊的版式设计。
除非特别声明，本刊刊出的所有文章不代表中华医学会和本刊编委会的观点。
冯攀：设计试验、数据整理、统计分析、技术支持、起草文章；刘涛：数据整理、统计分析、技术支持；徐楷：研究指导、论文修改；王毅博、张婷：采集数据
文档即答
智问智答
机器翻译
你好，我可以帮助您更好的了解本文，请向我提问您关注的问题。
