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ENGLISH ABSTRACT
虹吸法与离心法制备冷沉淀凝血因子的质量差异性对比分析
王红云
李建华
吴瑾惠
作者及单位信息
·
DOI： 10.3760/cma.j.cn341190-20240125-00114
Comparative analysis of quality differences between siphon and centrifugal methods for preparing cryoprecipitated coagulation factors
Wang Hongyun
Li Jianhua
Wu Jinhui
Authors Info & Affiliations
Wang Hongyun
Department of Blood Supply Service, Jiaxing Central Blood Station, Jiaxing 314001, Zhejiang Province, China
Li Jianhua
Department of Blood Supply Service, Jiaxing Central Blood Station, Jiaxing 314001, Zhejiang Province, China
Wu Jinhui
Department of Blood Supply Service, Jiaxing Central Blood Station, Jiaxing 314001, Zhejiang Province, China
·
DOI： 10.3760/cma.j.cn341190-20240125-00114
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摘要

目的对比分析虹吸法与离心法制备冷沉淀凝血因子的质量差异性。

方法前瞻性研究选取嘉兴市中心血站2023年1—12月从400 mL全血中分离制备的合格新鲜冰冻血浆76袋为观察对象，采用随机数字表法分为虹吸组与离心组，每组38袋。所有新鲜冰冻血浆均采用虹吸法或离心法制备，比较两组冷沉淀凝血因子容量，纤维蛋白原（fibrinogen，Fib）含量和凝血因子Ⅷ含量变化，Fib和凝血因子Ⅷ合格率。

结果两组制备的冷沉淀凝血因子容量比较，差异无统计学意义（ P > 0.05）。虹吸组Fib含量［（214.27±23.84）mg］、凝血因子Ⅷ含量［（105.10±17.58）IU］均显著高于离心组［（171.32±16.56）mg、（93.86±10.20）IU］（ t=9.12、3.41，均 P < 0.05）。两组Fib合格率比较，差异无统计学意义（ P > 0.05）。虹吸组凝血因子Ⅷ合格率［97.37%（37/38）］显著高于离心组［78.95%（30/38）］（ χ 2=4.54， P < 0.05）。

结论虹吸法与离心法制备冷沉淀凝血因子的质量均符合国家标准，而虹吸法制备合格率和质量更优。

输血;血浆;纤维蛋白原;因子Ⅷ;离心法
引用本文

王红云,李建华,吴瑾惠. 虹吸法与离心法制备冷沉淀凝血因子的质量差异性对比分析[J]. 中国基层医药,2025,32(03)：441-444.

DOI:10.3760/cma.j.cn341190-20240125-00114

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输血治疗是现阶段重要的一类治疗手段，成分输血是主要的输血方法，不仅可提高治疗效果，而且可有效降低不良反应 ［ 1 , 2 ］ 。随着血液管理的不断发展，临床输血的科学性、有效性及安全性很大程度上得到改善和提高 ［ 3 ］ 。冷沉淀凝血因子血液成分制品在临床上广泛地应用，通过凝血因子补充能够促进凝血系统功能恢复 ［ 4 ］ 。随着在临床上冷沉淀凝血因子需求量的不断增多，其制备的质量要求越来越高。选择合适的制备方法才能够确保冷沉淀凝血因子的活性及开发利用血液资源，提高血液质量，减少损耗，从而保证输血的安全性 ［ 5 , 6 ］ 。本研究通过对比分析虹吸法与离心法制备冷沉淀凝血因子的质量差异性，为制备方法的选择提供依据。现报告如下。
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备注信息
A
李建华，Email： mocdef.qabq463146406
B

王红云：酝酿和设计实验、实验研究、采集数据、分析/解释数据；李建华：酝酿和设计实验、对文章的知识性内容作批评性审阅；吴瑾惠：统计分析

C
王红云, 李建华, 吴瑾惠. 虹吸法与离心法制备冷沉淀凝血因子的质量差异性对比分析[J]. 中国基层医药,2025,32(3):441-444. DOI:10.3760/cma.j.cn341190-20240125-00114.
D
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