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ABO血型与三种癌症易感性的关系研究
姜桂华
徐军
徐立瑜
李建华
作者及单位信息
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DOI： 10.3760/cma.j.cn341190-20240716-00909
Relationship between ABO blood group and susceptibility to three types of cancer
Jiang Guihua
Xu Jun
Xu Liyu
Li Jianhua
Authors Info & Affiliations
Jiang Guihua
Institute of Blood Transfusion, Jiaxing Central Blood Station, Jiaxing 314000, Zhejiang Province, China
Xu Jun
Institute of Blood Transfusion, Jiaxing Central Blood Station, Jiaxing 314000, Zhejiang Province, China
Xu Liyu
Institute of Blood Transfusion, Jiaxing Central Blood Station, Jiaxing 314000, Zhejiang Province, China
Li Jianhua
Institute of Blood Transfusion, Jiaxing Central Blood Station, Jiaxing 314000, Zhejiang Province, China
·
DOI： 10.3760/cma.j.cn341190-20240716-00909
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摘要

20世纪初Karl Landsteiner发现了ABO血型系统，其是临床上最重要的血型系统之一。ABO血型抗原广泛存在于红细胞和其他组织上，因此该血型系统和疾病的关联备受瞩目。至今国内外已有大量关于ABO血型和癌症易感性的相关报道。因此，该研究主要对ABO血型和肺癌、胃癌、胰腺癌易感性的相关研究作一综述，为临床工作提供参考。

ABO血型系统;肺肿瘤;胃肿瘤;胰腺肿瘤;疾病易感性;综述
ABSTRACT

At the beginning of the 20 th century, Karl Landsteiner discovered the ABO blood group system, which is one of the most important blood good systems in clinical practice. ABO blood group antigens are widely present not only on red blood cells but also in various other tissues, making the association between this blood group system and cancers particularly significant. Numerous studies, both domestically and internationally, have explored the relationship between ABO blood group and cancer susceptibility. Therefore, this paper primarily reviews the research on the association between ABO blood group and susceptibility to lung cancer, gastric cancer, and pancreatic cancer, providing references for clinical practice.

ABO blood-group system;Lung neoplasms;Stomach neoplasms;Pancreatic neoplasms;Disease susceptibility;Review
Li Jianhua, Email: mocdef.qabq463146406
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引用本文

姜桂华,徐军,徐立瑜,等. ABO血型与三种癌症易感性的关系研究[J]. 中国基层医药,2025,32(03)：476-480.

DOI:10.3760/cma.j.cn341190-20240716-00909

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早在上世纪初，研究者们就开展了血型和疾病的关联研究 ［ 1 ］ 。统计显示ABO血型至少与40多种疾病的易感性相关，包括癌症 ［ 2 ］ 、消化系统疾病 ［ 3 ］ 、呼吸系统疾病 ［ 4 ］ 等，其中癌症相关的研究报道占比很高。2024年4月国家癌症中心公布了2022年中国恶性肿瘤疾病的负担情况，数据显示我国恶性肿瘤的死亡人数持续上升，占全球癌症死亡总人数的30%，并且用于恶性肿瘤相关的医疗支出超过了2 200亿 ［ 5 ］ 。癌症的发生毫无疑问是中国的重大公共卫生问题，所以研究癌症的发生和治疗将有助于降低未来医疗系统的负担。该文对国内外有关ABO血型与肺癌、胃癌和胰腺癌易感性的关联研究进行综述，以期为临床提供参考价值。
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备注信息
A
李建华，Email： mocdef.qabq463146406
B
姜桂华, 徐军, 徐立瑜, 等. ABO血型与三种癌症易感性的关系研究[J]. 中国基层医药,2025,32(3):476-480. DOI:10.3760/cma.j.cn341190-20240716-00909.
C
所有作者声明不存在利益冲突
D
浙江省血液安全研究重点实验室开放课题 (2023KF001)
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