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库欣病诊治专家共识(2025)
中华医学会内分泌学分会
作者及单位信息
·
DOI： 10.3760/cma.j.cn311282-20250126-00049
Expert consensus on the diagnosis and treatment of Cushing disease(2025)
Chinese Society of Endocrinology
Wang Weiqing
Authors Info & Affiliations
Chinese Society of Endocrinology
Wang Weiqing
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai National Clinical Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
·
DOI： 10.3760/cma.j.cn311282-20250126-00049
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摘要

库欣病临床症状轻重不一，累及全身，诊断和治疗极具挑战。近年来，库欣病病因机制的拓展、检查方法的更新、创新药物的研发为疾病认识和治疗带来了更多选择。为提高库欣病认识，规范疾病诊断、治疗和随访，由中华医学会内分泌学分会专家起草，经讨论和制定完成本库欣病诊治专家共识，旨在更好地指导临床实践，加强综合管理，改善患者生活质量。

库欣病;库欣综合征;合并症;复发;经蝶鞍垂体手术;药物治疗
ABSTRACT

Cushing disease presents a significant clinical challenge due to the variability in symptom severity and associated comorbidities. Recent advancements have improved our understanding of its underlying mechanisms, refined diagnostic approaches, and introduced innovative treatments strategies. To enhance clinical management and standardize diagnostic, therapeutic, and follow-up protocols, experts from endocrinology, surgery, and radiology collaborated to develop a consensus on the diagnosis and treatment of Cushing disease. This expert consensus serves as a guideline to improve clinical decision-making and optimize patient outcomes.

Cushing disease;Cushing syndrome;Comorbidities;Recurrence;Transsphenoidal surgery;Medical therapy
Wang Weiqing(Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai National Clinical Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China), Email: nc.defudabe.umshswgniqw
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引用本文

中华医学会内分泌学分会. 库欣病诊治专家共识(2025)[J]. 中华内分泌代谢杂志,2025,41(03)：186-197.

DOI:10.3760/cma.j.cn311282-20250126-00049

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库欣病(Cushing disease)由分泌促肾上腺皮质激素(adrenocorticotropic hormone, ACTH)的垂体腺瘤引起，可致高皮质醇血症，是内源性库欣综合征的最常见病因(60%～80%) [ 1 , 2 , 3 ]。库欣病占垂体肿瘤的15%，大多数为微腺瘤(直径<10 mm)，多数直径<6 mm；近10%为大腺瘤，可表现为侵袭性，向鞍外扩展或浸润 [ 4 , 5 , 6 ]。
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A
王卫庆[上海交通大学医学院附属瑞金医院内分泌代谢病科，上海市内分泌代谢病研究所，国家代谢性疾病临床医学研究中心(上海)，上海　200025]，Email： nc.defudabe.umshswgniqw
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国家科技部重点研发计划 (2021YFC2501600)
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