The aging population and changes in the disease spectrum have contributed to an increasing number of chronic refractory wounds, which not only cause physical and mental pain to patients and diminish their life quality, but also place a heavy burden on both their families and the society. Clinical practice has proven that establishing wound repair department for specialized treatment of chronic refractory wounds can effectively enhance treatment outcomes. As a newly established tertiary surgical discipline, wound repair discipline in China has been in development for 5 years. The authors outlined the main difficulties encountered during the establishment of wound repair discipline and summarized the key issues over the past 5 years. To solve these difficulties, the authors reviewed measures and achievements in areas such as raising people′s awareness, building standardized wards, exploring the multiple models of discipline construction, advancing research-oriented discipline construction, defining the scope of treatment, striving for service projects and promoting establishment of specialized level IV surgical systems, formulating a series of consensus guidelines for standardized treatment, developing and translating new wound repair technologies, creating a talent education and training system, expanding academic exchanges and cooperation, as well as fostering the growth of high-level disciplines, so as to offer references to support ongoing advancement in the establishment of wound repair discipline.