目的 对比99Tcm-替曲膦(TF)和99Tcm-MIBI G-MPI的左室心肌灌注及左室心功能参数结果,探讨99 Tcm-TF能否作为临床G-MPI常规显像剂.方法 99Tcm标记TF和MIBI并进行放化纯测定.选取2011年12月至2012年5月间既往健康、排除严重心律不齐及临床拟诊为心肌炎、心肌病的112例受试者(研究经医院伦理委员会批准,患者签署知情同意书),采用简单随机抽样法将其随机分成2组,分别行一日法99Tcm-TF(47例,运动负荷状态下注射显像剂370 MBq,静息状态下注射显像剂740 MBq)G-MPI和两日法99Tcm-MIBI(65例,注射剂量均为555 MBq)G-MPI,所有受试者均于1周内行CAG和UCG检查.利用Cedars定量门控SPECT(QGS)软件获得左室心功能参数,包括LVEF、EDV、ESV、峰充盈率(PFR)、峰射血率(PER)及相位标准差(SD).采用SPSS 17.0软件进行x2检验、两独立样本r检验、配对r检验及直线相关分析.结果 99 Tcm-TF和99Tcm-MIBI放化纯分别为(97.5±0.4)％和(99.1±0.2)％.与CAG结果对比,99Tcm-MIBI心肌灌注结果符合率为90.5％(57/63),99Tcm-TF为88.9％(40/45),两者差异无统计学意义(x2=0.389,P＞0.05).99Tcm-TF和99Tcm-MIBIG-MPI获得的左室心功能参数差异也无统计学意义[LVEF:(62.60±±13.56)％与(60.52±7.08)％,r=0.940;EDV:(103.31±17.29) ml与(98.52±19.37) ml,t=1.348;ESV:(41.73±12.69) ml与(46.05±10.81) ml,t=0.851;PER:(2.73±0.67) EDV/s与(2.61±1.04) EDV/s,t =0.725;PFR:(2.13±0.80) EDV/s与(2.07±1.09) EDV/s,t=0.339;相位SD:(5.58±4.16).与(5.97±4.64).,t=0.450,均P＞0.05].两者G-MPI获得的左室心功能参数与UCG结果差异无统计学意义[LVEF:(61.39±10.28)％与(62.13±8.51)％,t=0.991;EDV:(100.50±18.61) ml与(101.70±18.34) ml,t=1.806;ESV:(44.25±11.77) ml与(43.94±11.28)ml,t=0.658;均P＞0.05],且与UCG结果呈正相关(r=0.673、0.710和0.452,均P＜0.05).结论 99Tcm-TF可作为G-MPI显像剂常规用于临床,同时评价左室心肌灌注情况和左室功能。
Objective Tocompare the results of 99Tcm-tetrofosmin (TF) and 99Tcm-MIBI G-MPI in evaluating left ventricular myocardial perfusion and other functional parameters.Methods TF and MIBI were both labeled by 99Tcm and the radiochemical purities were tested.During December 2011 to May 2012,112 patients who had examinations of CAG and echocardiograph in one week after G-MPI were divided into 99Tcm-TF group (47 patients) and 99Tcm-MIBI group (65 patients) by simple random sampling.Patients who suffered from severe arrhythmia,clinically suspicious of mycarditis or cardiomyopathy were excluded.The research was approvel by the ethics committee,and all patients signed informed consents.One-day 99Tcm-TF G-MPI and two-day 99Tcm-MIBI G-MPI were performed.The left ventricular functional parameters were acquired automatically by Cedars quantitative gated SPECT (QGS) software,including LVEF,EDV,ESV,peak filling rate (PFR),peak ejection rate (PER) and phase standard difference (SD).The data were analyzed using x2 test,two-sample t test,paired t test and linear correlation analysis by SPSS 17.0.Results The radiochemical purities of 99Tcm-TF and 99Tcm-MIBI were (97.5±0.4) ％ and (99.1±0.2) ％ respectively.The coincidence rates of 99Tcm-TF and 99Tcm-MIBI G-MPI with CAG were 88.9％ (40/45) and 90.5％ (57/63),respectively.There was no significant difference between G-MPI results of the two agents (x2 =0.389,P＞0.05).There was also no significant difference between left ventricular functional parameters of the two agents (LVEF:(62.60±13.56)％ vs (60.52±7.08)％,t=0.940; EDV:(103.3±17.29) ml vs (98.52±19.37) ml,t=1.348; ESV:(41.73±12.69) ml vs (46.05±10.81) ml,t=0.851; PER:(2.73±0.67)EDV/s vs (2.61±1.04) EDV/s,t=0.725; PFR:(2.13±0.80) EDV/s vs (2.07±1.09) EDV/s,t=0.339;phase SD:(5.58±4.16)° vs (5.97±4.64)°,t=0.450; all P＞0.05).There was no significant difference between left ventricular functional parameters by G-MPI and UCG (LVEF:(61.39± 10.28) ％ vs (62.13±8.51) ％,t=0.991 ; EDV:(100.50±18.61) ml vs (101.70±18.34) ml,t=1.806; ESV:(44.25±11.77) ml vs (43.94±11.28) ml,t=0.658; all P＞0.05).LVEF,EDV,ESV by G-MPI correlated with the results of UCG (r=0.673,0.710,0.452,all P＜0.05).Conclusion 99Tcm-TF can also be used as a G-MPI agent to evaluate left ventricular myocardial perfusion and other functional parameters.
王瑞华,阮翘,孙珂,等. 99Tcm-替曲膦与99Tcm-MIBI门控心肌灌注显像的对比研究 : [J]. 中华核医学与分子影像杂志,2013,33(04)：258-262.
DOI:10.3760/cma.j.issn.2095-2848.2013.04.006
文档即答
智问智答
机器翻译
你好，我可以帮助您更好的了解本文，请向我提问您关注的问题。
