Objectives To observe the clinical effects of Fufang Xuanju capsules and Qilin Pills in patients oligoasthenospermia.Methods Using a self-controlled before and after taking one drug and a comparison of two drugs clinical trials,A total of 100 infertile men oligoasthenospermia were equally randomized into two groups.One group was treated with Fufang Xuanju capsules(3,3 times / day),Another was treated with Qilin pills(6g,3 times/ day) for 12 weeks as a course.We evaluated the efficacy of the drugs with sperm concentration and vitality(a + b) as the primary and the number of grade a sperm and sperm motility as the secondary therapeutic indexes.Results A total of 95 patients accomplished the clinical study.Two groups were significantly different before and after treatment in sperm concentration,vitality (a + b),the number of grade a sperm and sperm motility (P ＜ 0.05).The difference was statistically significant in two groups in sperm density,grade(a + b) sperm and the number of grade a sperm(P ＜ 0.05),whereas no statistically significant difference on sperm motility (P ＞ 0.05).Conclusions The two drugs both have a therapeutic effect on oligoasthenospermia,But Fufang Xuanju capsules is better than Qilin Pills.