论著
ENGLISH ABSTRACT
应用硬质支气管镜治疗中心气道狭窄的有效性和安全性研究
张红
王广发
章巍
李楠
龚玉红
作者及单位信息
·
DOI: 10.3760/cma.j.issn.1001-0939.2015.09.012
Clinical applications of rigid bronchoscopy in central airway obstructions
Zhang Hong
Wang Guangfa
Zhang Wei
Li Nan
Gong Yuhong
Authors Info & Affiliations
Zhang Hong
Department of Respiratory Medicine, Peking University First Hospital, Beijing 100034, China
Wang Guangfa
Zhang Wei
Li Nan
Gong Yuhong
·
DOI: 10.3760/cma.j.issn.1001-0939.2015.09.012
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摘要

目的观察硬质支气管镜在中心气道狭窄治疗中的有效性和安全性。

方法回顾性分析2008年12月至2014年12月北京大学第一医院接受硬质支气管镜检查和治疗的所有中心气道狭窄患者资料,比较其硬质支气管镜治疗前后气道狭窄程度百分比、肺功能、生活质量的变化,探讨硬质支气管镜手术缓解中心气道狭窄的作用,以及硬质支气管镜手术中的并发症。

结果共有132例严重中心气道狭窄的患者接受了209例次硬质支气管镜检查和治疗。患者年龄9~85岁(中位年龄59岁),男性占65%(86/132),恶性肿瘤占68%(90/132)。首次经硬质支气管镜治疗后受累气道狭窄程度明显减轻,气管狭窄程度术前为(63.3±22.4)%,术后为(17.8±16.0)%;左主支气管术前为(71.1±23.9)%,术后为(27.0±24.0)%,右主支气管术前为(73.0±26.2)%,术后为(34.9±29.8)%,差异有统计学意义( t值分别为21.9、12.3和11.2,均 P<0.01)。肺功能检查结果显示,流速相关指标FEV 1术前为(1.6±0.8)L,术后为(2.0±0.8)L,差异有统计学意义( t=3.84, P<0.01)。除扩张狭窄的气道外,本组还在硬质支气管镜下进行了支架置入、毁损支架取出、碎石等可弯曲镜下难以完成的操作。所有病例均没有出现危及生命的并发症。

结论硬质支气管镜可以快速开通气道,并在保证通气的前提下进行腔内复杂操作,可用于伴有呼吸衰竭的中心气道狭窄患者。

支气管镜检查;气道阻塞;支气管镜
ABSTRACT

ObjectiveRigid bronchoscopy has expanded for therapeutic purposes lately. It has a large diameter working channel, the ability to maintain proper ventilation during operation, and the capacity to deal with massive bleeding and other complications. Our purpose was to describe the effectiveness and safety of rigid bronchoscopy in central airway stenosis.

MethodsWe retrospectively analyzed all patients who had received rigid bronchoscopy for central airway obstruction in our respiratory department of this teaching hospital between December of 2008 and December of 2014. The advantages and limitations of the operations were analyzed through observing the changes of the degree of stenosis, pulmonary function, and Karnofsky performance status scale. Complications were also recorded.

ResultsTotally 209 rigid bronchoscopic procedures were performed in 132 patients with central airway stenosis (86 men; median age, 59 years; range, 9 to 85 years), of them 68% was malignancy. The rigid bronchoscopy provided immediate relief of central airway obstruction. Tracheal obstruction was (63.3±22.4)% before and (17.8±16.0)% after the procedures; obstruction in the left main bronchus was (71.1±23.9)% before and (27.0±24.0)% after the procedures; and the right main bronchus was (73.0±26.2)% before and (34.9±29.8)% after the procedures, ( t=21.85, 12.27, 11.17 separately, P<0.01). Spirometry revealed that FEV 1 improved significantly from (1.6±0.8) L before to (2.0±0.8) L after the procedures. Besides, many sophisticated procedures, such as stent implantation, corrupted metal stent removing and lithotripsy were performed under rigid bronchoscopy. There were no fatal complications.

ConclusionsRigid bronchoscopy provides immediate relief of central airway obstruction and maintains proper ventilation during sophisticated intraluminal operations. It provides better visualization for advanced procedures and is an optimal selection for securing the airway in severe central airway obstruction even with respiratory failure.

Bronchoscopy;Airway obstruction;Bronchoscopys
Wang Guangfa, Email: mocdef.labiamtohafgnauggnaw
引用本文

张红,王广发,章巍,等. 应用硬质支气管镜治疗中心气道狭窄的有效性和安全性研究[J]. 中华结核和呼吸杂志,2015,38(9):675-679.

DOI:10.3760/cma.j.issn.1001-0939.2015.09.012

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评价本文
*以上评分为匿名评价
支气管镜是不能手术的严重中心气道狭窄患者的重要治疗手段之一。硬质气管/支气管镜(硬镜)操作空间大,可以同时控制通气,有更通畅有效的吸引系统,作为治疗性支气管镜优势明显 [ 1 ]。20世纪60年代出现的可弯曲支气管镜(软镜或可弯曲镜),以其良好的耐受性和可操控性,在疾病诊断的应用中部分取代了硬镜,因此目前呼吸科医师对硬镜的使用比较陌生 [ 2 ]。近年来,随着介入呼吸病学的形成和发展,更多新的、实用的镜下治疗工具应用于临床,这些工具需要更大的操作空间和更好的内镜视野才能充分发挥功能。因此,硬镜的使用日趋增多,成为治疗性支气管镜的基础。北京大学第一医院呼吸和危重症医学科近年来应用硬镜对中心气道狭窄的患者实施检查和治疗,现报道如下。
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王广发,Email: mocdef.labiamtohafgnauggnaw
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