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间充质干细胞对视网膜疾病免疫调节的实验研究进展
杜玉芹
陈松 [综述]
作者及单位信息
·
DOI： 10.3760/cma.j.issn.2095-0160.2015.09.019
Experimental study progress in retinal disease immunomodulation by mesenchymal stem cells
Du Yuqin
Chen Song
Authors Info & Affiliations
Du Yuqin
Tianjin Key Laboratory of Ophthalmology and Vision Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin Medical University, Tianjin 300020, China
Chen Song
·
DOI： 10.3760/cma.j.issn.2095-0160.2015.09.019
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摘要

间充质干细胞(MSCs)是主要来源于中胚层的多能干细胞，具有来源广泛、易于获得、低免疫原性、多向分化潜能、损伤修复、营养神经等特点和功能，广泛应用于多种疾病的临床治疗。近年国内外学者对MSCs各种生理特点的研究不断深入，并且把MSCs应用于视网膜疾病的治疗。本文就MSCs的免疫特点，如免疫标记、免疫调节特性、营养作用，以及MSCs对糖尿病视网膜病变(DR)、视网膜退行性疾病、脉络膜新生血管(CNV)、视网膜缺血–再灌注的免疫调节应用进行综述。

间充质干细胞;免疫;糖尿病视网膜病变;脉络膜新生血管;视网膜疾病
ABSTRACT

Mesenchymal stem cells (MSCs) derive mainly from the mesoderm pluripotent stem cells, with wide variety of sources, easily accessible, low immunogenicity, pluripotent, various damage repair, nutrition, and other features and functions. MSCs are widely used for clinical treatment of various diseases. In recent years, scholars deepens various physiological characteristics of MSCs, and the MSCs have been used in the treatment of retinal diseases. In this paper, the characteristics of the MSCs, such as immune markers, immunomodulatory properties, the role of nutrition and MSCs immune on diabetic retinopathy (DR), retinal degenerative diseases, choroidal neovascular (CNV), retinal ischemia-reperfusion immunomodulatory applications were reviewed.

Mesenchymal stem cells;Immunity;Diabetic retinopathy;Choroidal neovascularization;Retinopathy
Chen Song, Email: mocdef.labiamtoh02gnosnehc
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引用本文

杜玉芹,陈松. 间充质干细胞对视网膜疾病免疫调节的实验研究进展[J]. 中华实验眼科杂志,2015,33(9)：853-856.

DOI:10.3760/cma.j.issn.2095-0160.2015.09.019

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充质干细胞(mesenchymal stem cells，MSCs)是干细胞家族的重要成员，来源于发育早期的中胚层和外胚层，属于全能干细胞。MSCs最初在骨髓中被发现，具有多向分化潜能、造血支持和促进干细胞植入、免疫调控和自我复制等特点。MSCs在特定的诱导条件下，可分化为脂肪、骨、软骨等多种组织细胞 [ 1 ]，连续传代培养和冷冻保存后仍然具有多向分化潜能 [ 2 ]，可作为理想的种子细胞用于衰老和病变引起的组织器官损伤修复。近年来随着对视网膜发病机制的研究及MSCs在各个治疗领域的应用越来越广泛，特别是MSCs在糖尿病视网膜病变(diabetic retinopathy，DR)、视网膜退行性疾病、脉络膜新生血管(choroidal neovascularization，CNV)、视网膜缺血–再灌注等领域。
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陈松，Email： mocdef.labiamtoh02gnosnehc
B
天津市科技计划项目 (13ZCDSY01500)
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