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ENGLISH ABSTRACT
Fractalkine/cx3cr1与小胶质细胞在眼底疾病中的研究进展
李娟娟
李燕 [综述]
作者及单位信息
·
DOI： 10.3760/cma.j.issn.2095-0160.2015.09.021
Research progression of Fractalkine/cx3cr1 and microglia in retina diseases
Li Juanjuan
Li Yan
Authors Info & Affiliations
Li Juanjuan
Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University, Kunming 650021, China
Li Yan
·
DOI： 10.3760/cma.j.issn.2095-0160.2015.09.021
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摘要

Fractalkine(Fkn)是趋化因子CX3C亚家族中目前发现的唯一成员，cx3cr1是其特异性受体。Fkn/cx3cr1参与炎症、肿瘤、自身免疫疾病、变态反应、获得性免疫缺陷综合征等多种疾病，同时多种病理生理作用是通过小胶质细胞来完成的。本文就Fkn/cx3cr1与小胶质细胞在年龄相关性黄斑病变、急性光损伤疾病、视网膜新生血管性疾病、糖尿病视网膜疾病、葡萄膜炎等眼底疾病中的研究进展进行综述。

Fractalkine;Cx3cr1;小胶质细胞;视网膜
ABSTRACT

Fractalkine (Fkn) is the only member of CX3C subfamily of chemokine currently found, cx3cr1 is its specific receptor. Fkn/cx3cr1 is involved in inflammation, cancer, autoimmune diseases, allergy, acquired immune deficiency syndrome and other diseases, while its variety of pathophysiological role is accomplished by microglia. Functions of Fkn/cx3cr1 and microglia in age-related macular degeneration, acute light damage disease, retinal vascular disease, diabetic retinopathy disease, uveitis and other retina disease were reviewed in this article.

Fractalkine;Cx3cr1;Microglia;Retina
Li Yan, Email: mocdef.labiam tohrnayil
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引用本文

李娟娟,李燕. Fractalkine/cx3cr1与小胶质细胞在眼底疾病中的研究进展[J]. 中华实验眼科杂志,2015,33(9)：861-864.

DOI:10.3760/cma.j.issn.2095-0160.2015.09.021

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Fractalkine(Fkn)是趋化因子CX3C亚家族中目前发现的唯一成员，cx3cr1是其特异性受体。Fkn/cx3cr1在机体发挥着诱导炎症细胞趋化、黏附，诱导自然杀伤细胞产生细胞毒性等生理和病理功能，参与炎症、肿瘤、自身免疫疾病、变态反应、获得性免疫缺陷综合征等多种疾病，成为目前研究的热点 [ 1 ]。在中枢神经系统中，Fkn主要表达于神经元，而cx3cr1则主要表达于小胶质细胞，因此Fkn/cx3cr1成为神经元与小胶质细胞之间重要的信号传导通路 [ 2 , 3 ]。Fkn/cx3cr1通过调控小胶质细胞的活性对神经元起作用，这种作用已在多种脑部疾病的研究中得到证实 [ 4 , 5 ]。视网膜神经元与小胶质细胞也有Fkn/cx3cr1的高表达，Fkn/cx3cr1是否也能通过调控视网膜小胶质细胞而在各类视网膜疾病中发挥作用？就Fkn/cx3cr1与小胶质细胞在多种视网膜疾病中的研究进展进行综述。
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李燕，Email： mocdef.labiamtohrnayjl
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