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紫外线A核黄素角膜交联的研究进展
朱奕睿
陈蔚
作者及单位信息
·
DOI： 10.3760/cma.j.issn.0412-4081.2015.09.019
The progress of UVA-riboflavin collagen crosslinking of the cornea
Zhu Yirui
Chen Wei
Authors Info & Affiliations
Zhu Yirui
Department of Ophthalmology, Eye Hospital of Wenzhou Medical University, Zhejiang 325000, China
Chen Wei
·
DOI： 10.3760/cma.j.issn.0412-4081.2015.09.019
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摘要

紫外线A核黄素角膜交联疗法是近年来兴起的通过紫外线A光和光敏剂核黄素诱导角膜基质胶原纤维相互交联，从而提高角膜硬度和改变生物学性能的新方法，临床上最早被应用于治疗圆锥角膜等角膜扩张性疾病。随着研究深入，角膜交联的模式不断创新，临床应用更加广泛。本文就角膜交联疗法模式的改进和临床应用等相关研究进展进行综述。 （中华眼科杂志，2015，51：715-720）

角膜;胶原;交联试剂;核黄素;紫外线;角膜疾病
ABSTRACT

UVA-riboflavin collagen crosslinking was introduced as a clinical application to stabilize the cornea by inducing crosslinks within and between collagen fibers. It has been shown clinically to arrest the progression of keratoconic ectasia. With further researches, the technical methods of collagen crosslinking have been improved, and the treatment range has been increased. This paper covers the researches on the innovative techniques and applications of collagen crosslinking. (Chin J Ophthalmol, 2015, 51: 715-720)

Cornea;Collagen;Cross-linking reagents;Riboflavin;Ultraviolet rays;Corneal diseases
Chen Wei, Email: mocdef.labiamtohdmiewnehc
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引用本文

朱奕睿,陈蔚. 紫外线A核黄素角膜交联的研究进展[J]. 中华眼科杂志,2015,51(9)：715-720.

DOI:10.3760/cma.j.issn.0412-4081.2015.09.019

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紫外线A核黄素角膜交联疗法是采用370 nm紫外线A光和光敏剂核黄素诱导角膜基质胶原纤维相互交联，从而提高角膜硬度和改变生物学性能的新方法。1990年德国科学家首次提出将角膜交联技术应用于提高角膜硬度，并开展了广泛的研究 [ 1 ]。在临床上角膜交联疗法最早被用于治疗进展期圆锥角膜、扩张性角膜疾病，2003年Wollensak等 [ 2 ]首次报道了紫外线A核黄素角膜交联疗法治疗圆锥角膜有效，具有创伤小、相对安全等特点，引起了眼科界的关注和重视。此后角膜交联疗法逐渐被应用于治疗感染性角膜炎、角膜溶解、大泡性角膜病变等角膜疾病。本文就角膜交联疗法的模式改进及其临床应用等相关研究进展进行总结和阐述。
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