高级检索
中华结核和呼吸杂志
期刊首页
过刊列表
高级检索
稿件发表
• 综述 •
肺部磨玻璃样病变的诊治进展
曹晓明
邓朝胜
林其昌
曹代荣
游瑞雄
作者及单位信息
·
DOI： 10.3760/cma.j.issn.1001-0939.2015.04.014
2415
190
0
0
0
1
PDF下载
APP内阅读
摘要

近年来随着胸部CT的普及，肺部磨玻璃密度影(ground glass opacity, GGO)的检出率明显提高，且部分GGO与早期肺癌，特别是支气管肺泡细胞癌(bronchioloalveolar carcinoma, BAC)相关，故临床医生对GGO的关注度提高。目前，肺癌在全世界癌症死亡原因中占首位，令人遗憾的是临床上很多患者发现时已属晚期，仅15%的患者有手术机会，术后5年生存率只有15% [ 1 ] 。据统计，Ⅳ期肺癌患者5年生存率仅为2%左右，早期发现并手术切除的Ⅰ期肺癌5年生存率为54%～73% [ 2 ] ，而以GGO为表现的早期肺癌患者术后5年生存率可达100% [ 3 ] 。因此，正确认识及处理肺部GGO，对肺癌的早期诊断、治疗及预后具有重要意义。

引用本文

曹晓明,邓朝胜,林其昌,等. 肺部磨玻璃样病变的诊治进展[J]. 中华结核和呼吸杂志,2015,38(4)：298-301.

DOI:10.3760/cma.j.issn.1001-0939.2015.04.014

PERMISSIONS

Request permissions for this article from CCC.

评价本文
*以上评分为匿名评价

版权归中华医学会所有。

未经授权，不得转载、摘编本刊文章，不得使用本刊的版式设计。

除非特别声明，本刊刊出的所有文章不代表中华医学会和本刊编委会的观点。

近年来随着胸部CT的普及，肺部磨玻璃密度影(ground glass opacity, GGO)的检出率明显提高，且部分GGO与早期肺癌，特别是支气管肺泡细胞癌(bronchioloalveolar carcinoma, BAC)相关，故临床医生对GGO的关注度提高。目前，肺癌在全世界癌症死亡原因中占首位，令人遗憾的是临床上很多患者发现时已属晚期，仅15%的患者有手术机会，术后5年生存率只有15% [ 1 ]。据统计，Ⅳ期肺癌患者5年生存率仅为2%左右，早期发现并手术切除的Ⅰ期肺癌5年生存率为54%～73% [ 2 ]，而以GGO为表现的早期肺癌患者术后5年生存率可达100% [ 3 ]。因此，正确认识及处理肺部GGO，对肺癌的早期诊断、治疗及预后具有重要意义。
试读结束，您可以通过登录机构账户或个人账户后获取全文阅读权限。
参考文献
[1]
Hocking WG , Hu P , Oken MM ,et al. Lung cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial[J]. J Nat Cancer Institute, 2010,102(10):722-731.
返回引文位置Google Scholar
百度学术
万方数据
[2]
Zhan P , Xie H , Xu C ,et al. Management strategy of solitary pulmonary nodules[J]. J Thorac Dis, 2013,5(6):824-829.
返回引文位置Google Scholar
百度学术
万方数据
[3]
汪金钱. 肺部局限性GGO的影像学诊断方法及外科处理策略[J]. 临床肺科杂志, 2013,18(6):1104-1105
返回引文位置Google Scholar
百度学术
万方数据
[4]
Lee HY , Lee KS . Ground-glass opacity nodules: histopathology, imaging evaluation, and clinical implications[J]. J Thorac Imaging, 2011,26(2):106-118.
返回引文位置Google Scholar
百度学术
万方数据
[5]
岳光华,曹中良. 肺局限性磨玻璃影病变36例临床分析[J]. 中华实验外科杂志, 2013,30(10):2229.
返回引文位置Google Scholar
百度学术
万方数据
[6]
Izumo T , Sasada S , Chavez C ,et al. The diagnostic utility of endobronchial ultrasonography with a guide sheath and tomosynthesis images for ground glass opacity pulmonary lesions[J]. J thorac Dis, 2013,5(6):745-750.
返回引文位置Google Scholar
百度学术
万方数据
[7]
Oda S , Awai K , Liu D ,et al. Ground-glass opacities on thin-section helical CT: differentiation between bronchioloalveolar carcinoma and atypical adenomatous hyperplasia[J]. AJR Am J Roentgenol, 2008,190(5):1363-1368.
返回引文位置Google Scholar
百度学术
万方数据
[8]
Travis WD , Brambilla E , Noguchi M ,et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma[J]. J Thorac Oncol, 2011,6(2):244-285.
返回引文位置Google Scholar
百度学术
万方数据
[9]
Lynch TJ , Bell DW , Sordella R ,et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib[J]. N Engl J Med, 2004,350(21):2129-2139.
返回引文位置Google Scholar
百度学术
万方数据
[10]
Aoki T , Hanamiya M , Uramoto H ,et al. Adenocarcinomas with predominant ground-glass opacity: correlation of morphology and molecular biomarkers[J]. Radiology, 2012,264(2):590-596.
返回引文位置Google Scholar
百度学术
万方数据
[11]
Hsu KH , Chen KC , Yang TY ,et al. Epidermal growth factor receptor mutation status in stage I lung adenocarcinoma with different image patterns[J]. J Thorac Oncol, 2011,6(6):1066-1072.
返回引文位置Google Scholar
百度学术
万方数据
[12]
Sakamoto H , Shimizu J , Horio Y ,et al. Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas[J]. J Pathol, 2007,212(3):287-294.
返回引文位置Google Scholar
百度学术
万方数据
[13]
Yoshida Y , Kokubu A , Suzuki K ,et al. Molecular markers and changes of computed tomography appearance in lung adenocarcinoma with ground-glass opacity[J]. Jpn J Clin Oncol, 2007,37(12):907-912.
返回引文位置Google Scholar
百度学术
万方数据
[14]
Nakata M , Saeki H , Takata I ,et al. Focal ground-glass opacity detected by low-dose helical CT[J]. Chest, 2002,121(5):1464-1467.
返回引文位置Google Scholar
百度学术
万方数据
[15]
Nakamura S , Fukui T , Taniguchi T ,et al. Prognostic impact of tumor size eliminating the ground glass opacity component: modified clinical T descriptors of the tumor, node, metastasis classification of lung cancer[J]. J Thorac Oncol, 2013,8(12):1551-1557.
返回引文位置Google Scholar
百度学术
万方数据
[16]
Matsuguma H , Oki I , Nakahara R ,et al. Comparison of three measurements on computed tomography for the prediction of less invasiveness in patients with clinical stage I non-small cell lung cancer[J]. Ann Thorac Surg, 2013,95(6):1878-1884.
返回引文位置Google Scholar
百度学术
万方数据
[17]
Hiramatsu M , Inagaki T , Inagaki T ,et al. Pulmonary ground-glass opacity (GGO) lesions-large size and a history of lung cancer are risk factors for growth[J]. J Thorac Oncol, 2008,3(11):1245-1250.
返回引文位置Google Scholar
百度学术
万方数据
[18]
Kobayashi Y , Sakao Y , Deshpande GA ,et al. The association between baseline clinical-radiological characteristics and growth of pulmonary nodules with ground-glass opacity[J]. Lung Cancer, 2014,83(1):61-66.
返回引文位置Google Scholar
百度学术
万方数据
[19]
Min JH , Lee HY , Lee KS ,et al. Stepwise evolution from a focal pure pulmonary ground-glass opacity nodule into an invasive lung adenocarcinoma: an observation for more than 10 years[J]. Lung Cancer, 2010,69(1):123-126.
返回引文位置Google Scholar
百度学术
万方数据
[20]
Chun EJ , Lee HJ , Kang WJ ,et al. Differentiation between malignancy and inflammation in pulmonary ground-glass nodules: The feasibility of integrated< sup> 18</sup> F-FDG PET/CT[J]. Lung Cancer, 2009,65(2):180-186.
返回引文位置Google Scholar
百度学术
万方数据
[21]
Shimizu K , Ikeda N , Tsuboi M ,et al. Percutaneous CT-guided fine needle aspiration for lung cancer smaller than 2 cm and revealed by ground-glass opacity at CT[J]. Lung Cancer, 2006,51(2):173-179.
返回引文位置Google Scholar
百度学术
万方数据
[22]
Hur J , Lee HJ , Nam JE ,et al. Diagnostic accuracy of CT fluoroscopy-guided needle aspiration biopsy of ground-glass opacity pulmonary lesions[J]. AJR Am J Roentgenol, 2009,192(3):629-634.
返回引文位置Google Scholar
百度学术
万方数据
[23]
Choi SH , Chae EJ , Kim JE ,et al. Percutaneous CT-guided aspiration and core biopsy of pulmonary nodules smaller than 1 cm: analysis of outcomes of 305 procedures from a tertiary referral center[J]. AJR Am J Roentgenol, 2013,201(5):964-970.
返回引文位置Google Scholar
百度学术
万方数据
[24]
Gould MK , Donington J , Lynch WR ,et al. Evaluation of individuals with pulmonary nodules: when is it lung cancer?: diagnosis and management of lung cancer: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.[J ]Chest, 2013,143(5 Suppl):e93S-e120S.
返回引文位置Google Scholar
百度学术
万方数据
[25]
Eberhardt R , Anantham D , Ernst A ,et al. Multimodality bronchoscopic diagnosis of peripheral lung lesions: a randomized controlled trial[J]. Am J Respir Crit Care Med, 2007,176(1):36-41.
返回引文位置Google Scholar
百度学术
万方数据
[26]
Wang Memoli JS , Nietert PJ , Silvestri GA ,et al. Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule[J]. Chest, 2012,142(2):385-393.
返回引文位置Google Scholar
百度学术
万方数据
[27]
Chavez C , Sasada S , Izumo T ,et al. Image-guided bronchoscopy for histopathologic diagnosis of pure ground glass opacity: a case report[J]. J Thorac Dis, 2014,6(6):E81-84.
返回引文位置Google Scholar
百度学术
万方数据
[28]
MacMahon H , Austin JHM , Gamsu G ,et al. Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society[J]. Radiology, 2005,237(2):395-400.
返回引文位置Google Scholar
百度学术
万方数据
[29]
Hartman TE , Midthun DE , Sloan JA ,et al. Lung cancer screening with CT: mayo clinic experience[J]. Radiology, 2003,226:756-761.
返回引文位置Google Scholar
百度学术
万方数据
[30]
Hasegawa M , Sone S , Takashima S ,et al. Growth rate of small lung cancers detected on mass CT screening[J]. Br J Radiol, 2000,73(876):1252-1259.
返回引文位置Google Scholar
百度学术
万方数据
[31]
Kobayashi Y , Fukui T , Ito S ,et al. How Long Should Small Lung Lesions of Ground-Glass Opacity be Followed?[J]. J Thorac Oncol, 2013,8(3):309-314.
返回引文位置Google Scholar
百度学术
万方数据
[32]
Lee SW , Leem CS , Kim TJ ,et al. The long-term course of ground-glass opacities detected on thin-section computed tomography[J]. Respir Med, 2013,107(6):904-910.
返回引文位置Google Scholar
百度学术
万方数据
[33]
Ichinose J , Kohno T , Fujimori S ,et al. Invasiveness and malignant potential of pulmonary lesions presenting as pure ground-glass opacities[J]. Ann Thorac Cardiovasc Surg, 2013.
返回引文位置Google Scholar
百度学术
万方数据
[34]
Cho S , Yang HC , Kim K ,et al. Pathology and prognosis of persistent stable pure ground-glass opacity nodules after surgical resection[J]. Ann Thorac Surg, 2013,96(4):1190-1195.
返回引文位置Google Scholar
百度学术
万方数据
[35]
Ye B , Cheng M , Ge XX ,et al. Factors that predict lymph node status in clinical stage T1aN0M0 lung adenocarcinomas[J]. World J Surg Oncol, 2014,12(1):42.
返回引文位置Google Scholar
百度学术
万方数据
[36]
Godoy MCB , Naidich DP . Subsolid pulmonary nodules and the spectrum of peripheral adenocarcinomas of the lung: recommended interim guidelines for assessment and management[J]. Radiology, 2009,253(3):606.
返回引文位置Google Scholar
百度学术
万方数据
[37]
Rami-Porta R , Tsuboi M . Sublobar resection for lung cancer[J]. European Respiratory Journal, 2009,33(2):426-435.
返回引文位置Google Scholar
百度学术
万方数据
[38]
Van Schil PE , Asamura H , Rusch VW ,et al. Surgical implications of the new IASLC/ATS/ERS adenocarcinoma classification[J]. Eur Respir J, 2012,39(2):478-486.
返回引文位置Google Scholar
百度学术
万方数据
[39]
叶波,冯键,潘旭峰,等. T1a期肺腺癌影像学特征与淋巴结转移相关性分析[J]. 中华外科杂志, 2013,51(10):904-907.
返回引文位置Google Scholar
百度学术
万方数据
[40]
Kodama H , Yamakado K , Hasegawa T ,et al. Radiofrequency ablation for ground-glass opacity-dominant lung adenocarcinoma[J]. J Vasc Interv Radiol, 2014,25(3):333-339.
返回引文位置Google Scholar
百度学术
万方数据
[41]
Iguchi T , Hiraki T , Gobara H ,et al. Percutaneous radiofrequency ablation of lung cancer presenting as ground-glass opacity[J]. Cardiovasc Intervent Radiol, 2014, [Epub ahead of print].
返回引文位置Google Scholar
百度学术
万方数据
备注信息
A
邓朝胜，Email： mocdef.6ab213337gnehs
B
福建省科技厅重点项目 (2014Y0020)
评论 （0条）
注册
登录
时间排序
暂无评论，发表第一条评论抢沙发
最新推荐
更多
小细胞肺癌免疫治疗专家共识（2025版）
中国临床肿瘤学会小细胞肺癌专家委员会 等
中华肿瘤杂志 2025,47(01)
ⅡB～ⅢA期小细胞肺癌手术治疗的临床价值
祝慧燕 等
国际呼吸杂志 2024,44(07)
阿帕替尼在广泛期小细胞肺癌一线及维持治疗的效果评价
刘静 等
中国医师进修杂志 2022,45(07)
基于更全面变量预测小细胞肺癌2年生存率的列线图模型构建
魏丽娟 等
中华医学杂志 2022,102(17)
MedAI助手（体验版）
文档即答
智问智答
机器翻译
回答内容由人工智能生成，我社无法保证其准确性和完整性，该生成内容不代表我们的态度或观点，仅供参考。
生成快照
文献快照

你好，我可以帮助您更好的了解本文，请向我提问您关注的问题。

0/2000

《中华医学会杂志社用户协议》 | 《隐私政策》

《SparkDesk 用户协议》 | 《SparkDesk 隐私政策》

网信算备340104764864601230055号 | 网信算备340104726288401230013号

技术支持：

历史对话
本文全部
还没有聊天记录
设置
模式
纯净模式沉浸模式
字号
小中大