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ENGLISH ABSTRACT
Toll样受体在真菌性角膜炎中的调控作用
王露萍
吴欣怡 [综述]
作者及单位信息
·
DOI： 10.3760/cma.j.issn.2095-0160.2015.10.019
Regulation of Toll-like receptors in fungal keratitis
Wang Luping
Wu Xinyi
Authors Info & Affiliations
Wang Luping
Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, China
Wu Xinyi
·
DOI： 10.3760/cma.j.issn.2095-0160.2015.10.019
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摘要

真菌性角膜炎(FK)是一种严重的致盲眼病，而Toll样受体(TLRs)在哺乳动物识别真菌的过程中发挥重要作用。大量证据表明，TLRs启动FK的天然免疫，也参与机体针对真菌的获得性免疫反应。本文探讨了TLRs与非TLRs信号通路的相互作用、TLRs信号通路的负性调节因子及TLRs在角膜真菌感染中的作用，以期为角膜真菌感染的治疗提供新的策略。

角膜炎，真菌性;Toll样受体;信号转导;Nod样受体;Dectin-1;免疫耐受
ABSTRACT

Fungal keratitis (FK), a potential blinding disease, has been difficult to treat due to the limited number of approved antifungal drugs and the taxing dosing regimen.Toll-like receptors (TLRs) function as the pattern recognition receptors (PRRs) in mammals and play an essential role in the recognition of fungal components.There is a great amount of evidence that TLRs initiate the innate immunity in the FK.Furthermore, TLRs also play roles in shaping fungal-specific humoral and cellular adaptive immune responses.This review described the recent advances in interaction between TLRs and non-TLRs signal transduction, negative regulator and function of TLRs in corneal fungal infection.

Keratitis, fungal;Toll-like receptors;Signal transduction;Nod-like receptors;Dectin-1;Immune tolerance
Wu Xinyi, Email: mocdef.3ab618688uwyx
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引用本文

王露萍,吴欣怡. Toll样受体在真菌性角膜炎中的调控作用[J]. 中华实验眼科杂志,2015,33(10)：953-956.

DOI:10.3760/cma.j.issn.2095-0160.2015.10.019

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真菌性角膜炎(fungal keratitis，FK)是一种由致病真菌引起的致盲率极高的感染性角膜病变。FK的发病与植物性外伤密切相关，如不能及时治疗将导致角膜穿孔、失明，甚至眼球摘除。随着抗生素、糖皮质激素和免疫抑制剂的广泛应用以及角膜接触镜佩戴者的增多，FK的发病率不断升高，在某些地区甚至跃居感染性角膜疾病首位 [ 1 , 2 , 3 ]，其中镰刀菌和曲霉菌是主要的致病菌 [ 4 , 5 ]。角膜与角膜缘是多层次、多功能的防御组织，泪膜均匀地涂布于角膜表面。泪液可通过机械冲刷及其内含的抗菌成分，如分泌型免疫球蛋白、溶菌酶、β溶素、乳铁蛋白等，抑制微生物生长，构成了眼表天然免疫的一道屏障。
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备注信息
A
吴欣怡，Email： mocdef.3ab618688uwyx
B
国家自然科学基金项目 (81470604)
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