高级检索
中华实验眼科杂志
期刊首页
过刊列表
高级检索
稿件发表
• 综述 •
ENGLISH ABSTRACT
角膜基质蛋白研究进展
玄猛
张妍
王淑荣 [综述]
作者及单位信息
·
DOI： 10.3760/cma.j.issn.2095-0160.2015.11.017
Recent advances in corneal stroma protein studies
Xuan Meng
Zhang Yan
Wang Shurong
Authors Info & Affiliations
Xuan Meng
Department of Ophthalmology, Norman Bethune Health Science of Jilin University, Changchun 130021, China
Zhang Yan
Wang Shurong
·
DOI： 10.3760/cma.j.issn.2095-0160.2015.11.017
758
93
0
0
0
0
PDF下载
APP内阅读
摘要

蛋白质是角膜基质的主要组成成分，由角膜上皮细胞、基质细胞、内皮细胞分泌到细胞外基质。SDS-聚丙烯酰胺凝胶分离技术和光谱测定技术已确定了在蛋白质序列数据库中标注的1 679种角膜基质蛋白质。基质蛋白在角膜的病理生理过程中具有重要的作用，对其功能的研究有助于揭示多种眼科疾病的发病机制，并为相关病变的防治提供新的思路。从基质蛋白的表现形式上看，其构成了角膜基质的凝胶样成分和纤维网架样结构，凝胶样基质包括蛋白聚糖、酶类、血清蛋白和结合蛋白，纤维网架包括胶原、弹性蛋白、角蛋白、波形蛋白以及起黏着作用的纤维连接蛋白和层黏连蛋白。本文就基质蛋白在组成和功能上的研究进展进行综述。

角膜;基质;蛋白聚糖;糖蛋白;胶原
ABSTRACT

Cornea stroma mostly consists of proteins in extracellular matrix secreted by corneal epithelial cells, stroma and endothelial cells.A total of 1 679 unique Swiss-Prot annotated proteins are identified by LC-MS/MS analyses in human corneal stroma based on SDS-PAGE separation followed by in-gel trypsin digestion.As the principal component of corneal stroma, corneal stroma proteins play an important role in the physiological and pathological activities of eye.Studies towards their functions are helpful for revealing the pathogenesis of eye diseases and providing new ideas of prevention and therapy.Mainly through their manifestations, proteins in corneal stroma play a key role in forming gel-like organic material and network like structure of filaments.The gel-like organic material is composed of proteoglycan, enzymes, haemocyanin and binding proteins, while the network of filaments are constituted by collagen, elastin, keratin, vimentin as well as interconnected filaments made from fibronectin and laminin.The categories and functions of corneal stroma proteins were summarized.

Cornea;Stroma;Proteoglycan;Glucoprotein;Collagen
Zhang Yan, Email: nc.defudabe.ulj66ygnahz
Copyright by Chinese Medical Association
No content published by the journals of Chinese Medical Association may be reproduced or abridged without authorization. Please do not use or copy the layout and design of the journals without permission.
All articles published represent the opinions of the authors, and do not reflect the official policy of the Chinese Medical Association or the Editorial Board, unless this is clearly specified.
引用本文

玄猛,张妍,王淑荣. 角膜基质蛋白研究进展[J]. 中华实验眼科杂志,2015,33(11)：1043-1047.

DOI:10.3760/cma.j.issn.2095-0160.2015.11.017

PERMISSIONS

Request permissions for this article from CCC.

评价本文
*以上评分为匿名评价

版权归中华医学会所有。

未经授权，不得转载、摘编本刊文章，不得使用本刊的版式设计。

除非特别声明，本刊刊出的所有文章不代表中华医学会和本刊编委会的观点。

角膜是眼的生理结构中屈光力最强的介质 [ 1 ]，由5层组织构成。角膜基质层是一层透明柔软的屈光组织，其厚度的改变可影响眼的屈光状态，是准分子激光微创角膜屈光手术的操作层。目前许多研究围绕角膜基质蛋白组展开，如研究定位于基质层内疾病的分子机制 [ 2 ]，制作低免疫性的角膜蛋白网络支架 [ 3 ]，探讨角膜营养障碍的病理机制，分析基质成分变异与角膜感染的急性炎症反应的关系 [ 4 ]，寻找构建人工角膜基质的合适材料和方法 [ 5 , 6 , 7 ]，探究细胞外基质和细胞的联系 [ 8 ]等。然而，角膜基质层组成的复杂性、分子结构的高度组织性、生物力学的稳固性和透光性为这些研究带来了很多挑战 [ 9 ]。因此，探讨角膜基质最主要的成分——基质蛋白及其功能十分必要。从结构表现形式上看，基质蛋白构成了角膜基质的凝胶样和纤维网架样结构。凝胶样基质包括蛋白聚糖、酶类、血清蛋白、结合蛋白，纤维网架包括胶原、弹性蛋白以及起黏着作用的纤维连接蛋白(fibronectin，FN)和层黏连蛋白(laminin，LN)，本文对其分别进行阐述。
试读结束，您可以通过登录机构账户或个人账户后获取全文阅读权限。
参考文献
[1]
Chen S , Mienaltowski MJ , Birk DE . Regulation of corneal stroma extracellular matrix assembly[J]. Exp Eye Res, 2015,133:69-80. doi: 10.1016/j.exer.2014.08.001 .
返回引文位置Google Scholar
百度学术
万方数据
[2]
Chaerkady R , Shao H , Scott SG ,et al. The keratoconus corneal proteome: loss of epithelial integrity and stromal degeneration[J]. J Proteomics, 2013,87:122-131. doi: 10.1016/j.jprot.2013.05.023 .
返回引文位置Google Scholar
百度学术
万方数据
[3]
Mi S , Connon CJ . The formation of a tissue-engineered cornea using plastically compressed collagen scaffolds and limbal stem cells[J]. Methods Mol Biol, 2013,1014:143-155. doi: 10.1007/978-1-62703-432-6_9 .
返回引文位置Google Scholar
百度学术
万方数据
[4]
Yuan X , Hua X , Wilhelmus KR . Expression of small leucine-rich proteoglycans during experimental fungal keratitis[J]. Cornea, 2010,29(6):674-679. doi: 10.1097/ICO.0b013e3181c29744 .
返回引文位置Google Scholar
百度学术
万方数据
[5]
Fuchsluger T , Salehi S , Petsch C ,et al. New possibilities for ocular surface reconstruction: collagen membranes and biocompatible elastomer nanofibers[J]. Ophthalmologe, 2014,111(11):1019-1026. doi: 10.1007/s00347-013-3010-z .
返回引文位置Google Scholar
百度学术
万方数据
[6]
Boulze Pankert M , Goyer B , Zaguia F ,et al. Biocompatibility and functionality of a tissue-engineered living corneal stroma transplanted in the feline eye[J]. Invest Ophthalmol Vis Sci, 2014,55(10):6908-6920. doi: 10.1167/iovs.14-14720 .
返回引文位置Google Scholar
百度学术
万方数据
[7]
Wu J , Du Y , Mann MM ,et al. Bioengineering organized, multilamellar human corneal stromal tissue by growth factor supplementation on highly aligned synthetic substrates[J]. Tissue Eng Part A, 2013,19(17-18):2063-2075. doi: 10.1089/ten.TEA.2012.0545 .
返回引文位置Google Scholar
百度学术
万方数据
[8]
Choi JS , Kim EY , Kim MJ ,et al. In vitro evaluation of the interactions between human corneal endothelial cells and extracellular matrix proteins[J/OL]. Biomed Mater, 2013,8(1):014108[2015-05-23]. http: //iopscience.iop.org/article/10.1088/1748-6041/8/1/014108/meta；jsessionid＝D4C00C3C2F96B80F11DFEEC5668E5528.c1.doi: 10.1088/1748-6041/8/1/014108.
返回引文位置Google Scholar
百度学术
万方数据
[9]
Wu J , Rnjak-Kovacina J , Du Y ,et al. Corneal stromal bioequivalents secreted on patterned silk substrates[J]. Biomaterials, 2014,35(12):3744-3755. doi: 10.1016/j.biomaterials.2013.12.078 .
返回引文位置Google Scholar
百度学术
万方数据
[10]
Halper J . Proteoglycans and diseases of soft tissues[J]. Adv Exp Med Biol, 2014,802:49-58. doi: 10.1007/978-94-007-7893-1_4 .
返回引文位置Google Scholar
百度学术
万方数据
[11]
Chen S , Young MF , Chakravarti S ,et al. Interclass small leucine-rich repeat proteoglycan interactions regulate collagen fibrillogenesis and corneal stromal assembly[J]. Matrix Biol, 2014,35:103-111. doi: 10.1016/j.matbio.2014.01.004 .
返回引文位置Google Scholar
百度学术
万方数据
[12]
Yang CH , Culshaw GJ , Liu MM ,et al. Canine tissue-specific expression of multiple small leucine rich proteoglycans[J]. Vet J, 2012,193(2):374-380. doi: 10.1016/j.tvjl.2012.01.018 .
返回引文位置Google Scholar
百度学术
万方数据
[13]
Chen S , Birk DE . Focus on molecules: decorin[J]. Exp Eye Res, 2011,92(6):444-445. doi: 10.1016/j.exer.2010.05.008 .
返回引文位置Google Scholar
百度学术
万方数据
[14]
Mohan RR , Tovey JC , Gupta R ,et al. Decorin biology, expression, function and therapy in the cornea[J]. Curr Mol Med, 2011,11(2):110-128. doi: 10.2174/156652411794859241 .
返回引文位置Google Scholar
百度学术
万方数据
[15]
Jing Y , Kumar PR , Zhu L ,et al. Novel decorin mutation in a Chinese family with congenital stromal corneal dystrophy[J]. Cornea, 2014,33(3):288-293. doi: 10.1097/ICO.0000000000000055 .
返回引文位置Google Scholar
百度学术
万方数据
[16]
Chen S , Sun M , Meng X ,et al. Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy: C-terminal-truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans[J]. Am J Pathol, 2011,179(5):2409-2419. doi: 10.1016/j.ajpath.2011.07.026 .
返回引文位置Google Scholar
百度学术
万方数据
[17]
Mohan RR , Gupta R , Mehan MK ,et al. Decorin transfection suppresses profibrogenic genes and myofibroblast formation in human corneal fibroblasts[J]. Exp Eye Res, 2010,91(2):238-245. doi: 10.1016/j.exer.2010.05.013 .
返回引文位置Google Scholar
百度学术
万方数据
[18]
Bredrup C , Stang E , Bruland O ,et al. Decorin accumulation contributes to the stromal opacities found in congenital stromal corneal dystrophy[J]. Invest Ophthalmol Vis Sci, 2010,51(11):5578-5582. doi: 10.1167/iovs.09-4933 .
返回引文位置Google Scholar
百度学术
万方数据
[19]
Mohan RR , Tovey JC , Sharma A ,et al. Targeted decorin gene therapy delivered with adeno-associated virus effectively retards corneal neovascularization in vivo[J/OL]. PLoS One, 2011,6(10):e26432[2015-04-18]. http: //journals.plos.org/plosone/article？id＝10.1371/journal.pone.0026432.doi: 10.1371/journal.pone.0026432.
返回引文位置Google Scholar
百度学术
万方数据
[20]
Mohan RR , Tandon A , Sharma A ,et al. Significant inhibition of corneal scarring in vivo with tissue-selective, targeted AAV5 decorin gene therapy[J]. Invest Ophthalmol Vis Sci, 2011,52(7):4833-4841. doi: 10.1167/iovs.11-7357 .
返回引文位置Google Scholar
百度学术
万方数据
[21]
Liu CY , Kao WW . Lumican promotes corneal epithelial wound healing[J]. Methods Mol Biol, 2012,836:285-290. doi: 10.1007/978-1-61779-498-8_18 .
返回引文位置Google Scholar
百度学术
万方数据
[22]
Shao H , Chaerkady R , Chen S ,et al. Proteome profiling of wild type and lumican-deficient mouse corneas[J]. J Proteomics, 2011,74(10):1895-1905. doi: 10.1016/j.jprot.2011.04.032 .
返回引文位置Google Scholar
百度学术
万方数据
[23]
Funderburgh JL , Corpuz LM , Roth MR ,et al. Mimecan, the 25-kDa corneal keratan sulfate proteoglycan, is a product of the gene producing osteoglycin[J]. J Biol Chem, 1997,272(44):28089-28095. doi: 10.1074/jbc.272.44.28089 .
返回引文位置Google Scholar
百度学术
万方数据
[24]
年娣，王萍．Mimecan基因的研究进展[J]．国际病理科学与临床杂志， 2009，29(1):41-44. doi: 10.3969/j.issn.1673-2588.2009.01.009 .
返回引文位置Google Scholar
百度学术
万方数据
[25]
Zhang G , Chen S , Goldoni S ,et al. Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan[J]. J Biol Chem, 2009,284(13):8888-8897. doi: 10.1074/jbc.M806590200 .
返回引文位置Google Scholar
百度学术
万方数据
[26]
Liu CY , Birk DE , Hassell JR ,et al. Keratocan-deficient mice display alterations in corneal structure[J]. J Biol Chem, 2003,278(24):21672-21677. doi: 10.1074/jbc.M301169200 .
返回引文位置Google Scholar
百度学术
万方数据
[27]
Schönherr E , Sunderkötter C , Schaefer L ,et al. Decorin deficiency leads to impaired angiogenesis in injured mouse cornea[J]. J Vasc Res, 2004,41(6):499-508. doi: 10.1159/000081806 .
返回引文位置Google Scholar
百度学术
万方数据
[28]
Zhang Y , Conrad AH , Conrad GW . Effects of ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking[J]. J Biol Chem, 2011,286(15):13011-13022. doi: 10.1074/jbc.M110.169813 .
返回引文位置Google Scholar
百度学术
万方数据
[29]
Corpuz LM , Funderburgh JL , Funderburgh ML ,et al. Molecular cloning and tissue distribution of keratocan: bovine corneal keratan sulfate proteoglycan 37A[J]. J Biol Chem, 1996,271(16):9759-9763. doi: 10.1074/jbc.271.16.9759 .
返回引文位置Google Scholar
百度学术
万方数据
[30]
Mankus C , Chi C , Rich C ,et al. The P2X(7) receptor regulates proteoglycan expression in the corneal stroma[J]. Mol Vis, 2012,18:128-138.
返回引文位置Google Scholar
百度学术
万方数据
[31]
Kim MJ , Frausto RF , Rosenwasser GO ,et al. Posterior amorphous corneal dystrophy is associated with a deletion of small leucine-rich proteoglycans on chromosome 12[J/OL]. PLoS One, 2014,9(4):e95037[2015-06-23]. http: //journals.plos.org/plosone/article？id＝10.1371/journal.pone.0095037.doi: 10.1371/journal.pone.0095037.
返回引文位置Google Scholar
百度学术
万方数据
[32]
Reinhard J , Joachim SC , Faissner A . Extracellular matrix remodeling during retinal development[J]. Exp Eye Res, 2015,133:132-140. doi: 10.1016/j.exer.2014.07.001 .
返回引文位置Google Scholar
百度学术
万方数据
[33]
Du L , Wu X . Development and characterization of a full-thickness acellular porcine cornea matrix for tissue engineering[J]. Artif Organs, 2011,35(7):691-705. doi: 10.1111/j.1525-1594.2010.01174.x .
返回引文位置Google Scholar
百度学术
万方数据
[34]
Zhou Q , Yang L , Qu M ,et al. Role of senescent fibroblasts on alkali-induced corneal neovascularization[J]. J Cell Physiol, 2012,227(3):1148-1156. doi: 10.1002/jcp.22835 .
返回引文位置Google Scholar
百度学术
万方数据
[35]
Lakeland TV , Borg ML , Matzaris M ,et al. Augmented expression and secretion of adipose-derived pigment epithelium-derived factor does not alter local angiogenesis or contribute to the development of systemic metabolic derangements[J]. Am J Physiol Endocrinol Metab, 2014,306(12):1367-1377. doi: 10.1152/ajpendo.00046.2014 .
返回引文位置Google Scholar
百度学术
万方数据
[36]
Cortina MS , He J , Li N ,et al. Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery[J]. Arch Ophthalmol, 2012,130(1):76-83. doi: 10.1001/archophthalmol.2011.287 .
返回引文位置Google Scholar
百度学术
万方数据
[37]
Kuo CN , Yang LC , Yang CT ,et al. Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesis[J]. Exp Eye Res, 2009,89(5):678-685. doi: 10.1016/j.exer.2009.06.021 .
返回引文位置Google Scholar
百度学术
万方数据
[38]
Uzunalli G , Soran Z , Erkal TS ,et al. Bioactive self-assembled peptide nanofibers for corneal stroma regeneration[J]. Acta Biomater, 2014,10(3):1156-1166. doi: 10.1016/j.actbio.2013.12.002 .
返回引文位置Google Scholar
百度学术
万方数据
[39]
Gordon SR . Fibronectin antibody labels corneal stromal collagen fibrils in situ along their length and circumference and demonstrates distinct staining along the cell and stromal interfaces of Descemet's membrane[J]. Curr Eye Res, 2014,39(3):312-316. doi: 10.3109/02713683.2013.841260 .
返回引文位置Google Scholar
百度学术
万方数据
[40]
Ali S , Saik JE , Gould DJ ,et al. Immobilization of cell-adhesive laminin peptides in degradable PEGDA hydrogels influences endothelial cell tubulogenesis[J]. Biores Open Access, 2013,2(4):241-249. doi: 10.1089/biores.2013.0021 .
返回引文位置Google Scholar
百度学术
万方数据
[41]
Knupp C , Pinali C , Lewis PN ,et al. The architecture of the cornea and structural basis of its transparency[J]. Adv Protein Chem Struct Biol, 2009,78:25-49. doi: 10.1016/S1876-1623(08)78002-7 .
返回引文位置Google Scholar
百度学术
万方数据
[42]
El Kadmiri N , Slassi I , El Moutawakil B ,et al. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease[J]. Pathol Biol (Paris), 2014,62(6):333-336. doi: 10.1016/j.patbio.2014.08.002 .
返回引文位置Google Scholar
百度学术
万方数据
[43]
Coleman JOD , Kalff BMMA , Davies TGE . Detoxification of xenobiotics by plants: chemical modification and vacuolar compartmentation[J]. Trends in Plant Science, 1997,2:144-151.
返回引文位置Google Scholar
百度学术
万方数据
[44]
Dudakova L , Liskova P , Trojek T ,et al. Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas[J]. Exp Eye Res, 2012,104:74-81. doi: 10.1016/j.exer.2012.09.005 .
返回引文位置Google Scholar
百度学术
万方数据
[45]
Kadomatsu T , Tabata M , Oike Y . Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases[J]. FEBS J, 2011,278(4):559-564. doi: 10.1111/j.1742-4658.2010.07979.x .
返回引文位置Google Scholar
百度学术
万方数据
[46]
Byström B , Carracedo S , Behndig A ,et al. Alpha11 integrin in the human cornea: importance in development and disease[J]. Invest Ophthalmol Vis Sci, 2009,50(11):5044-5053. doi: 10.1167/iovs.08-3261 .
返回引文位置Google Scholar
百度学术
万方数据
[47]
Nees DW , Fariss RN , Piatigorsky J . Serum albumin in mammalian cornea: implications for clinical application[J]. Invest Ophthalmol Vis Sci, 2003,44(8):3339-3345.
返回引文位置Google Scholar
百度学术
万方数据
[48]
Dassati S , Waldner A , Schweigreiter R . Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain[J]. Neurobiol Aging, 2014,35(7):1632-1642. doi: 10.1016/j.neurobiolaging.2014.01.148 .
返回引文位置Google Scholar
百度学术
万方数据
[49]
Boot-Handford RP , Tuckwell DS . Fibrillar collagen: the key to vertebrate evolution.A rate of molecular incest[J]. Bioessays, 2003,25(2):142-151. doi: 10.1002/bies.10230 .
返回引文位置Google Scholar
百度学术
万方数据
[50]
Exposito JY , Cluzel C , Garrone R ,et al. Evolution of collagens[J]. Anat Rec, 2002,268(3):302-316. doi: 10.1002/ar.10162 .
返回引文位置Google Scholar
百度学术
万方数据
[51]
Wojcik KA , Blasiak J , Szaflik J ,et al. Role of biochemical factors in the pathogenesis of keratoconus[J]. Acta Biochim Pol, 2014,61(1):55-62.
返回引文位置Google Scholar
百度学术
万方数据
[52]
Petsche SJ , Pinsky PM . The role of 3-D collagen organization in stromal elasticity: a model based on X-ray diffraction data and second harmonic-generated images[J]. Biomech Model Mechanobiol, 2013,12(6):1101-1113. doi: 10.1007/s10237-012-0466-8 .
返回引文位置Google Scholar
百度学术
万方数据
[53]
Morishige N , Shin-Gyou-Uchi R , Azumi H ,et al. Quantitative analysis of collagen lamellae in the normal and keratoconic human cornea by second harmonic generation imaging microscopy[J]. Invest Ophthalmol Vis Sci, 2014,55(12):8377-8385. doi: 10.1167/iovs.14-15348 .
返回引文位置Google Scholar
百度学术
万方数据
[54]
Hassell JR , Birk DE . The molecular basis of corneal transparency[J]. Exp Eye Res, 2010,91(3):326-335. doi: 10.1016/j.exer.2010.06.021 .
返回引文位置Google Scholar
百度学术
万方数据
[55]
Gil ES , Mandal BB , Park SH ,et al. Helicoidal multi-lamellar features of RGD-functionalized silk biomaterials for corneal tissue engineering[J]. 2010,31(34):8953-8963. doi: 10.1016/j.biomaterials.2010.08.017 .
返回引文位置Google Scholar
百度学术
万方数据
[56]
Li Y , Ho D , Meng H ,et al. Direct detection of collagenous proteins by fluorescently labeled collagen mimetic peptides[J]. Bioconjug Chem, 2013,24(1):9-16. doi: 10.1021/bc3005842 .
返回引文位置Google Scholar
百度学术
万方数据
[57]
Wei X , Cai SP , Zhang X ,et al. Is low dose of estrogen beneficial for prevention of glaucoma？[J]. Med Hypotheses, 2012,79(3):377-380. doi: 10.1016/j.mehy.2012.05.041 .
返回引文位置Google Scholar
百度学术
万方数据
[58]
Lu H , Zimek A , Chen J ,et al. Keratin 5 knockout mice reveal plasticity of keratin expression in the corneal epithelium[J]. Eur J Cell Biol, 2006,85(8):803-811. doi: 10.1016/j.ejcb.2006.04.001 .
返回引文位置Google Scholar
百度学术
万方数据
[59]
Joseph R , Srivastava OP , Pfister RR . Differential epithelial and stromal protein profiles in keratoconus and normal human corneas[J]. Exp Eye Res, 2011,92(4):282-298. doi: 10.1016/j.exer.2011.01.008 .
返回引文位置Google Scholar
百度学术
万方数据
[60]
Liu XY , Chen J , Zhou Q ,et al. In vitro tissue engineering of lamellar cornea using human amniotic epithelial cells and rabbit cornea stroma[J]. Int J Ophthalmol, 2013,6(4):425-429. doi: 10.3980/j.issn.2222-3959.2013.04.03 .
返回引文位置Google Scholar
百度学术
万方数据
[61]
Courtney DG , Atkinson SD , Allen EH ,et al. siRNA silencing of the mutant keratin 12 allele in corneal limbal epithelial cells grown from patients with Meesmann's epithelial corneal dystrophy[J]. Invest Ophthalmol Vis Sci, 2014,55(5):3352-3360. doi: 10.1167/iovs.13-12957 .
返回引文位置Google Scholar
百度学术
万方数据
[62]
Chaurasia SS , Kaur H , de Medeiros FW ,et al. Reprint of "Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury"[J]. Exp Eye Res, 2009,89(4):590-596. doi: 10.1016/S0014-4835(09)00247-4 .
返回引文位置Google Scholar
百度学术
万方数据
[63]
Das SK , Gupta I , Cho YK ,et al. Vimentin knockdown decreases corneal opacity[J]. Invest Ophthalmol Vis Sci, 2014,55(7):4030-4040. doi: 10.1167/iovs.13-13494 .
返回引文位置Google Scholar
百度学术
万方数据
[64]
Dyrlund TF , Poulsen ET , Scavenius C ,et al. Human cornea proteome: identification and quantitation of the proteins of the three main layers including epithelium, stroma, and endothelium[J]. J Proteome Res, 2012,11(8):4231-4239. doi: 10.1021/pr300358k .
返回引文位置Google Scholar
百度学术
万方数据
备注信息
A
张妍，Email： nc.defudabe.ulj66ygnahz
B
吉林省科技厅国际合作项目 (20130413025GH)
吉林省卫生厅青年基金项目 (2013Q005)
评论 （0条）
注册
登录
时间排序
暂无评论，发表第一条评论抢沙发
最新推荐
更多
角膜屈光手术中影响高阶像差的因素
何笑英 等
中华眼视光学与视觉科学杂志 2023,25(03)
角膜应力-应变指数在圆锥角膜诊断中的价值及CXL术后角膜生物力学参数变化的研究
刘国英 等
中华眼科杂志 2022,58(08)
中国人工角膜移植手术专家共识（2021年）
中华医学会眼科学分会角膜病学组
中华眼科杂志 2021,57(10)
角膜后表面散光的评估方法及临床特征的研究进展
蒋元丰 等
中华眼视光学与视觉科学杂志 2021,23(11)
MedAI助手（体验版）
文档即答
智问智答
机器翻译
回答内容由人工智能生成，我社无法保证其准确性和完整性，该生成内容不代表我们的态度或观点，仅供参考。
生成快照
文献快照

你好，我可以帮助您更好的了解本文，请向我提问您关注的问题。

0/2000

《中华医学会杂志社用户协议》 | 《隐私政策》

《SparkDesk 用户协议》 | 《SparkDesk 隐私政策》

网信算备340104764864601230055号 | 网信算备340104726288401230013号

技术支持：

历史对话
本文全部
还没有聊天记录
设置
模式
纯净模式沉浸模式
字号
小中大