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哺乳动物雷帕霉素靶蛋白信号通路与眼科疾病相关性的研究进展
张桂铭
刘红玲
傅少颖 [综述]
作者及单位信息
·
DOI： 10.3760/cma.j.issn.2095-0160.2015.11.018
Advance in research on the relationship between mammalian target of rapamycin signaling pathway and ophthalmic diseases
Zhang Guiming
Liu Hongling
Fu Shaoying
Authors Info & Affiliations
Zhang Guiming
Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China
Liu Hongling
Fu Shaoying
·
DOI： 10.3760/cma.j.issn.2095-0160.2015.11.018
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摘要

哺乳动物雷帕霉素靶蛋白(mTOR)是一种高度进化保守的蛋白激酶，控制细胞生长、生长因子和细胞能量的形成，参与营养、新陈代谢及老化过程，近年发现mTOR信号通路与细胞生长、调控蛋白质合成代谢密切相关，已成为肿瘤形成、代谢紊乱、神经系统疾病和炎症等疾病的重要通路。就mTOR及通路介导的眼科疾病进行综述。

哺乳动物雷帕霉素靶蛋白;信号通路;雷帕霉素;眼科疾病
ABSTRACT

Mammalian target of rapamycin (mTOR) is a highly evolutionary conserved protein kinase and plays a critical role in the regulation of cell growth, growth factors and cell energy, and thus contributes to the formation of nutrition, metabolism and aging processes.Recent studies found that mTOR signaling pathway is associated with cell cycle, protein synthesis and metabolism, and it is an important pathway of diseases such as development of tumor, metabolic disorders, nervous system disease and inflammation.The relationship between mTOR signaling pathway and ophthalmic diseases was reviewed in this article.

Mammalian target of rapamycin;Signaling pathway;Rapamycin;Ophthalmic diseases
Fu Shaoying, Email: mocdef.6ab21gniyoahsuf
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引用本文

张桂铭,刘红玲,傅少颖. 哺乳动物雷帕霉素靶蛋白信号通路与眼科疾病相关性的研究进展[J]. 中华实验眼科杂志,2015,33(11)：1048-1051.

DOI:10.3760/cma.j.issn.2095-0160.2015.11.018

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哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin，mTOR)广泛存在于各种生物细胞中，是一种负责调节细胞生长和营养代谢、生长因子和细胞能量的重要信号，与生物的新陈代谢和年龄相关性疾病密切相关 [ 1 ]。1991年Heitman等 [ 2 ]在啤酒酵母菌中发现TOR蛋白，1994年Takei等 [ 3 ]分别在哺乳动物中也发现此蛋白，命名为mTOR蛋白。近年研究发现，哺乳动物在mTOR信号调节异常时会发生癌症、肥胖、2型糖尿病和退行性神经病变等疾病。
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备注信息
A
傅少颖，Email： mocdef.6ab21gniyoahsuf
B
国家自然科学基金项目 (30970749、81301325)
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