讲座
钙代谢与妊娠期糖尿病的关系
陈蕾
徐先明
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DOI: 10.3760/cma.j.issn.0529-567X.2015.12.018
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摘要

妊娠期糖尿病(gestational diabetes mellitus, GDM)是指在妊娠期发生或首次发现的因糖耐量受损而引起的不同程度糖代谢异常 [ 1 ] ,在我国发病率约为3%,流行病学资料显示,随着人们生活方式的改变及疾病检出率的提高,GDM的发病率呈逐年上升趋势 [ 2 ] 。妊娠期间胰岛素敏感性较妊娠前降低,易发生胰岛素抵抗,约6%的孕妇可发生GDM [ 3 ] 。已经确定,Ca 2+作为一种重要的细胞内第二信使,在胰岛素信号传导通路中发挥一定作用。目前认为,胰岛素抵抗与Ca 2+的跨膜运转和代谢等有密切的关系 [ 4 , 5 , 6 ] 。本文针对这个专题进行讲座。

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陈蕾,徐先明. 钙代谢与妊娠期糖尿病的关系[J]. 中华妇产科杂志,2015,50(12):961-963.

DOI:10.3760/cma.j.issn.0529-567X.2015.12.018

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妊娠期糖尿病(gestational diabetes mellitus, GDM)是指在妊娠期发生或首次发现的因糖耐量受损而引起的不同程度糖代谢异常 [ 1 ],在我国发病率约为3%,流行病学资料显示,随着人们生活方式的改变及疾病检出率的提高,GDM的发病率呈逐年上升趋势 [ 2 ]。妊娠期间胰岛素敏感性较妊娠前降低,易发生胰岛素抵抗,约6%的孕妇可发生GDM [ 3 ]。已经确定,Ca 2+作为一种重要的细胞内第二信使,在胰岛素信号传导通路中发挥一定作用。目前认为,胰岛素抵抗与Ca 2+的跨膜运转和代谢等有密切的关系 [ 4 , 5 , 6 ]。本文针对这个专题进行讲座。
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